Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Yuemin Bian"'
Publikováno v:
Frontiers in Molecular Biosciences, Vol 10 (2023)
High-throughput screening (HTS) methods enable the empirical evaluation of a large scale of compounds and can be augmented by virtual screening (VS) techniques to save time and money by using potential active compounds for experimental testing. Struc
Externí odkaz:
https://doaj.org/article/535ef8d01e024811995501da78009c18
Autor:
Yan Chen, Yuemin Bian, Jian-Wei Wang, Ting-Ting Gong, You-Min Ying, Lie-Feng Ma, Wei-Guang Shan, Xiang-Qun Xie, Zha-Jun Zhan
Publikováno v:
ACS Omega, Vol 5, Iss 17, Pp 9846-9863 (2020)
Externí odkaz:
https://doaj.org/article/056d95617e614bae9e1d5d2d889b12e7
Autor:
Yuemin Bian, Xiang-Qun Xie
Publikováno v:
Cells, Vol 11, Iss 5, p 915 (2022)
Design and generation of high-quality target- and scaffold-specific small molecules is an important strategy for the discovery of unique and potent bioactive drug molecules. To achieve this goal, authors have developed the deep-learning molecule gene
Externí odkaz:
https://doaj.org/article/7bcf312d6f29487789262eb27526386c
Publikováno v:
Biomolecules, Vol 11, Iss 6, p 870 (2021)
G-protein-coupled receptors (GPCRs) are the largest and most diverse group of cell surface receptors that respond to various extracellular signals. The allosteric modulation of GPCRs has emerged in recent years as a promising approach for developing
Externí odkaz:
https://doaj.org/article/dff3e293143048f184b7fff29493de08
Autor:
Laurens Moore van Tienen, Shadwa Bayoumi, Khaja Muneeruddin, Nancy Leymarie, David Kornfilt, Yuemin Bian, Devishi Kesar, Ruitong Li, Thomas Atack, Alexandra-Mariela Popa, Zuzana Jandova, Philipp Trollmann, Andreas Bergner, Klaus Rumpel, Dirk Kessler, William R. Sellers
Publikováno v:
Molecular Cancer Research. 21:B037-B037
Large-scale cancer sequencing efforts coupled with deep functional genomic interrogation of cancer models provides us an increasingly detailed view of the critical cancer drivers required for persistent growth and survival of cancer cells. Targeting
Autor:
You-Min Ying, Jian-Wei Wang, Zha-Jun Zhan, Gong Tingting, Yan Chen, Xiang-Qun Xie, Lie-Feng Ma, Yuemin Bian, Wei-Guang Shan
Publikováno v:
ACS Omega, Vol 5, Iss 17, Pp 9846-9863 (2020)
ACS Omega
ACS Omega
α-Mangostin (α-M) is a natural xanthone from the pericarp of fruit Garcinia mangostana and possesses versatile biological activities. α-M has a therapeutic potential to treat Alzheimer’s disease (AD) because of its anti-inflammatory, antioxidati
Publikováno v:
Molecular Pharmaceutics. 16:4451-4460
A deep convolutional generative adversarial network (dcGAN) model was developed in this study to screen and design target-specific novel compounds for cannabinoid receptors. In the adversarial process of training, two models, the discriminator D and
Autor:
Jason Kwon, Behnoush Hajian, Yuemin Bian, Alvaro Amor, James Fuller, Cara Fraley, Laura Baker, Jonathan So, David Mayhew, Abbey Sykes, Nicole Persky, Xiaoping Yang, David Root, Charles Perry, Christopher Lemke, William Hahn, Andrew Aguirre
Publikováno v:
Cancer Research. 82:LB029-LB029
Receptor tyrosine kinase (RTK)-RAS signaling through the downstream mitogen activated protein kinase (MAPK) cascade regulate cell proliferation and survival. The SHOC2 holophosphatase functions as a key regulator of RTK-RAS signaling by removing an i
Autor:
Xiang-Qun Xie, Yuemin Bian
Publikováno v:
Journal of molecular modeling. 27(3)
The de novo design of molecular structures using deep learning generative models introduces an encouraging solution to drug discovery in the face of the continuously increased cost of new drug development. From the generation of original texts, image
Publikováno v:
The AAPS Journal. 19:1235-1248
GPCR allosteric modulators target at the allosteric binding pockets of G protein-coupled receptors (GPCRs) with indirect influence on the effects of an orthosteric ligand. Such modulators exhibit significant advantages compared to the corresponding o