Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Yuelong Yan"'
Autor:
Dadi Jiang, Youming Guo, Tianyu Wang, Liang Wang, Yuelong Yan, Ling Xia, Rakesh Bam, Zhifen Yang, Hyemin Lee, Takao Iwawaki, Boyi Gan, Albert C. Koong
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Cellular sensitivity to ferroptosis is primarily regulated by mechanisms mediating lipid hydroperoxide detoxification. We show that inositol-requiring enzyme 1 (IRE1α), an endoplasmic reticulum (ER) resident protein critical for the unfolde
Externí odkaz:
https://doaj.org/article/598a0a1540c54c13967d9aaf0c35d304
Autor:
Yuelong Yan, Hongqi Teng, Qinglei Hang, Lavanya Kondiparthi, Guang Lei, Amber Horbath, Xiaoguang Liu, Chao Mao, Shiqi Wu, Li Zhuang, M. James You, Masha V. Poyurovsky, Li Ma, Kellen Olszewski, Boyi Gan
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract The cystine transporter solute carrier family 7 member 11 (SLC7A11; also called xCT) protects cancer cells from oxidative stress and is overexpressed in many cancers. Here we report a surprising finding that, whereas moderate overexpression
Externí odkaz:
https://doaj.org/article/da19c3ea1b9f437293e3f0769baf2529
Autor:
Yuelong Yan, Chao Zhang, Jing Hao, Xue-Lian Wang, Jia Ming, Li Mi, Jie Na, Xinli Hu, Yangming Wang
Publikováno v:
PLoS Biology, Vol 21, Iss 11, p e3002379 (2023)
[This corrects the article DOI: 10.1371/journal.pbio.3000324.].
Externí odkaz:
https://doaj.org/article/16fb2c991dad481db04c4aa1905bad78
Publikováno v:
Water Science and Technology, Vol 86, Iss 3, Pp 555-567 (2022)
Sulfidated nano zero-valent iron supported by activated carbon (S-nZVI/AC) composites were synthesized via liquid phase reduction method, and then they were used for Cr(VI) elimination. Characterization results showed that Fe0 was the main component,
Externí odkaz:
https://doaj.org/article/f3fb59c292a34ae1a60d3633d4588a13
Autor:
Pranavi Koppula, Guang Lei, Yilei Zhang, Yuelong Yan, Chao Mao, Lavanya Kondiparthi, Jiejun Shi, Xiaoguang Liu, Amber Horbath, Molina Das, Wei Li, Masha V. Poyurovsky, Kellen Olszewski, Boyi Gan
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
KEAP1 mutations are frequently observed in NSCLC and lead to drug resistance. Here, the authors show that KEAP1 mutations in lung cancer cells leads to FSP1 upregulation through NRF2, resulting in ferroptosis resistance and radioresistance.
Externí odkaz:
https://doaj.org/article/5fc916fe8ad34fc4b73b85133a6b2a8c
Publikováno v:
Molecular & Cellular Oncology, Vol 8, Iss 3 (2021)
Ferroptosis is a cell death mechanism triggered by lipid peroxidation. Our recent study linked cyst(e)ine availability with glutathione peroxidase 4 (GPX4) protein synthesis and ferroptosis mitigation via a Rag-mechanistic target of rapamycin complex
Externí odkaz:
https://doaj.org/article/fe2aec4fbbdd4db5b8d49a8f6780bddf
Autor:
Xiaoguang Liu, Litong Nie, Yilei Zhang, Yuelong Yan, Chao Wang, Medina Colic, Kellen Olszewski, Amber Horbath, Xiong Chen, Guang Lei, Chao Mao, Shiqi Wu, Li Zhuang, Masha V. Poyurovsky, M. James You, Traver Hart, Daniel D. Billadeau, Junjie Chen, Boyi Gan
Publikováno v:
Nature Cell Biology. 25:404-414
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::934ad9521e14e770c3797dfe35e09d52
https://doi.org/10.1038/s41556-023-01091-2
https://doi.org/10.1038/s41556-023-01091-2
Autor:
Kellen L. Olszewski, Guang Lei, Shiqi Wu, Xiaoguang Liu, Bingliang Fang, Yilei Zhang, Li Zhuang, Chao Mao, Masha V. Poyurovsky, Boyi Gan, Yuelong Yan, Hyemin Lee, Pranavi Koppula
Publikováno v:
Nature
Ferroptosis, a form of regulated cell death induced by excessive lipid peroxidation, has recently emerged as a key tumor suppression mechanism(1–4). Glutathione peroxidase 4 (GPX4)(5, 6) and ferroptosis suppressor protein 1 (FSP1)(7, 8) constitute
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b20990789cff66d78dde277886a6d2d9
https://doi.org/10.1038/s41586-021-03539-7
https://doi.org/10.1038/s41586-021-03539-7
Autor:
Guang Lei, Anil K. Sood, Yuelong Yan, Boyi Gan, Pranavi Koppula, Chao Mao, Jinsong Liu, Xudong Zhang, Weijie Cheng, Ting Hong, Yilei Zhang, Xiaoguang Liu
Publikováno v:
Oncogene
Ferroptosis, a form of regulated cell death triggered by lipid peroxidation, was recently identified as an important mechanism in radiotherapy (RT)-mediated tumor suppression and radioresistance, although the exact genetic contexts in which to target
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06069a59c2fa1f44311d66312e874d92
https://doi.org/10.1038/s41388-021-01790-w
https://doi.org/10.1038/s41388-021-01790-w
Publikováno v:
Protein & Cell
Ferroptosis, an iron-dependent form of regulated cell death driven by peroxidative damages of polyunsaturated-fatty-acid-containing phospholipids in cellular membranes, has recently been revealed to play an important role in radiotherapy-induced cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3409cbd83e77fc5a25d6faaa4aa94dfc
https://doi.org/10.1007/s13238-021-00841-y
https://doi.org/10.1007/s13238-021-00841-y