Výsledky vyhledávání

Abstract 1321: TPX-0022, a polypharmacology inhibitor of MET/CSF1R/SRC for treatment of cancers with abnormal HGF/MET signaling

Autor: Dayong Zhai, Evan Rogers, Wei Deng, Xin Zhang, Dong Lee, Jane Ung, Han Zhang, Jing Liu, Yuelie Lu, John Huang, Armin Graber, Zach Zimmerman, John Lim, Jeffrey Whitten, J. Jean Cui

Publikováno v: Cancer Research. 79:1321-1321

Aberrant activation of the HGF/MET pathway has frequently been found in human cancers via MET mutation, gene amplification and translocation, as well as HGF paracrine or autocrine upregulation. The abnormal HGF/MET signaling not only acts as an oncog

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c197c7db0a18d31ab1784b4d7118b70d
https://doi.org/10.1158/1538-7445.am2019-1321

Zobrazit plný text záznamu

Abstract 1325: TPX-0022, a polypharmacology inhibitor of MET/CSF1R/SRC inhibits tumor growth by promoting anti-tumor immune responses

Autor: Yuelie Lu, Jeffrey P. Whitten, Wei Deng, Dayong Zhai, Jing Liu, Zach Zimmerman, Han Zhang, J. Jean Cui, John Huang, Evan Rogers, Armin Graber, Ung Jane, John Lim, Xin Zhang, Dong Lee

Publikováno v: Cancer Research. 79:1325-1325

In the tumor microenvironment, tumor associated macrophages (TAMs) support tumor growth by suppressing antitumor immune responses and promoting angiogenesis, which is associated with disease progression and poor clinical outcomes. In contrast to the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1267c76f646b15c8963076acb06c4d24
https://doi.org/10.1158/1538-7445.am2019-1325

Zobrazit plný text záznamu

Practical synthesis of potent sphingosine-1-phosphate lyase inhibitors THI and LX2931

Autor: Wenxue Wu, Gonzalo Hernandez, Weifeng Hu, Renmao Liu, Xiaogen Yang, Mark S. Bednarz, Jie Yan, Haiming Zhang, Lawrence F. Courtney, Yuelie Lu, Jason G. Chen

Publikováno v: Tetrahedron. 69:4041-4046

A practical and scalable synthesis of in vivo sphingosine-1-phosphate lyase inhibitor LX2931 (1) is described. The synthetic route features an improved Buchi cyclocondensation of 2-ethoxyacrylonitrile (3) with either 1-amino-1-deoxy-d-fructose acetat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ed02592a918bb4652d893c11092a71f5
https://doi.org/10.1016/j.tet.2013.03.071

Zobrazit plný text záznamu

Synthesis of heterocycles via ligand-free palladium catalyzed reductive Heck cyclization

Autor: Rob Larsen, Jeffrey Adams, Liang Huang, Pingli Liu, Yuelie Lu, Tingjian Xiang, Margaret M. Faul, Andrew Tasker, Jean Baum, Mina Dilmeghani

Publikováno v: Tetrahedron Letters. 48:2307-2310

Synthesis of five and six membered heterocycles, indolines, 2,3-dihydrobenzofurans, chromans, isochromans, 1,2,3,4-tetrahydroquinolines, and 1,2,3,4-tetrahydroisoquinolines, in 70–99% yield by a ligand-free palladium catalyzed reductive Heck cycliz

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a3c560fa0ffd7ad541954558f6f6e059
https://doi.org/10.1016/j.tetlet.2007.01.156

Zobrazit plný text záznamu

N-Aryl-γ-lactams as integrin αvβ3 antagonists

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 14:2905-2909

Novel αvβ3 antagonists based on the N-aryl-γ-lactam scaffold were prepared. SAR studies led to the identification of potent antagonists for αvβ3 receptor with excellent selectivity against the structurally related αIIbβ3 receptor. Additional i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6327503f49e45e3cee545d9f88871868
https://doi.org/10.1016/j.bmcl.2004.03.033

Zobrazit plný text záznamu

Structure−Activity Relationships of a Series of Pyrrolo[3,2-d]pyrimidine Derivatives and Related Compounds as Neuropeptide Y5 Receptor Antagonists

Autor: William Karbon, Nianhe Han, Ning Chen, Mark H. Norman, Vincent Santora, John Kincaid, Clarence Hale, Longbin Liu, Ofir A. Moreno, Christopher H. Fotsch, Tracy J. Jenkins, Zhidong Chen, Ray Hurt, Jennifer D. Sonnenberg, Yuelie Lu

Publikováno v: Journal of Medicinal Chemistry. 43:4288-4312

Neuropeptide Y (NPY) has been shown to play an important role in the regulation of food intake and energy balance. Pharmacological data suggests that the Y5 receptor subtype contributes to the effects of NPY on appetite, and therefore a Y5 antagonist

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4068b1ab5c5e1bb842b212e1c5c9cd7a
https://doi.org/10.1021/jm000269t

Zobrazit plný text záznamu

An Efficient Process for the Synthesis of trans-2,3-Disubstituted-2,3-dihydro-4H-1-benzopyran-4-ones (Chroman-4-ones)

Autor: Richard W. Draper, Eugene J. Vater, Bin Hu, Mohammad Ataur Rahman, Xun Li, Yuelie Lu, Radha V. Iyer

Publikováno v: Tetrahedron. 56:1811-1817

The piperidine catalyzed Knoevenagel condensation of 2′-aryl/alkyl-2-hydroxyacetophenones 7 and aryl/alkylaldehydes 8 in refluxing isopropyl alcohol with azeotropic removal of water affords, in high yield, equilibrium mixtures of E - and Z -chalcon

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7893821b8b5d869b0ca9a6e8bc07aefd
https://doi.org/10.1016/s0040-4020(00)00101-0

Zobrazit plný text záznamu

ChemInform Abstract: An Efficient Process for the Synthesis of trans-2,3-Disubstituted-2,3-dihydro-4H-1-benzopyran-4-ones (Chroman-4-ones)

Autor: Eugene J. Vater, Xun Li, Richard W. Draper, Radha V. Iyer, Mohammad Ataur Rahman, Yuelie Lu, Bin Hu

Publikováno v: ChemInform. 31

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::808a89c3b4c9223c2ec566fc559792d4
https://doi.org/10.1002/chin.200026132

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání