Výsledky vyhledávání - "Yueh-tyng Chien"

Akademický článek

Olinciguat, an Oral sGC Stimulator, Exhibits Diverse Pharmacology Across Preclinical Models of Cardiovascular, Metabolic, Renal, and Inflammatory Disease

Publikováno v: Frontiers in Pharmacology, Vol 11 (2020)

Nitric oxide (NO)-soluble guanylate cyclase (sGC)-cyclic 3',5' GMP (cGMP) signaling plays a central role in regulation of diverse processes including smooth muscle relaxation, inflammation, and fibrosis. sGC is activated by the short-lived physiologi

Externí odkaz: https://doaj.org/article/e994be112c3a40db87031271143e9556

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Effects of the Soluble Guanylate Cyclase Stimulator Praliciguat in Diabetic Kidney Disease

Autor: George Bakris, Albert T. Profy, Jennifer G. Chickering, Jelena P. Seferovic, John P. Hanrahan, Ian H. de Boer, Michael D. Cressman, Mark G. Currie, James Wakefield, G. Todd Milne, Kenneth E. Carlson, Phebe J. Wilson, Yueh-Tyng Chien

Publikováno v: Clin J Am Soc Nephrol

Background and objectives Impaired nitric oxide signaling through soluble guanylate cyclase has been implicated in the pathophysiology of diabetic kidney disease. Praliciguat, a soluble guanylate cyclase stimulator that amplifies nitric oxide signali

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d5a08796e56d4397df9ed0dd1e1a556
https://doi.org/10.2215/cjn.08410520

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Olinciguat, an Oral sGC Stimulator, Exhibits Diverse Pharmacology Across Preclinical Models of Cardiovascular, Metabolic, Renal, and Inflammatory Disease

Publikováno v: Frontiers in Pharmacology
Frontiers in Pharmacology, Vol 11 (2020)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::235faf214a0dad4f1fdd0e1ad72b1cd8
https://pubmed.ncbi.nlm.nih.gov/32322204

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Discovery and development of next generation sGC stimulators with diverse multidimensional pharmacology and broad therapeutic potential

Autor: Regina Graul, Jennifer G. Chickering, Daniel P. Zimmer, Yueh-Tyng Chien, George Todd Milne, Jaime L. Masferrer, John R. Hadcock, Emmanuel S. Buys, Albert T. Profy

Publikováno v: Nitric Oxide. 78:72-80

Nitric oxide (NO)-sensitive soluble guanylyl cyclase (sGC), an enzyme that catalyzes the conversion of guanosine-5'-triphosphate (GTP) to cyclic guanosine-3',5'-monophophate (cGMP), transduces many of the physiological effects of the gasotransmitter

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b94683b3d8f60510c8bfee0cfce67b6
https://doi.org/10.1016/j.niox.2018.05.009

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Agr-independent regulation of fibronectin-binding protein(s) by the regulatory locus sar in Staphylococcus aureus

Autor: Ambrose L. Cheung, Petra Pöhlmann-Dietze, Yueh-tyng Chien, Willem J B van Wamel, Adhar C. Manna, Andrea Steinhuber, Christiane Wolz

Publikováno v: Molecular Microbiology. 36:230-243

Fibronectin-binding proteins (FnBPs) are thought to be important for the attachment of Staphylococcus aureus during infection. The regulation of the genes fnbA and fnbB by the global regulatory loci sar and agr was examined using site-specific regula

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82ea1518e33815f4ad6c8e3a3aa7699e
https://doi.org/10.1046/j.1365-2958.2000.01853.x

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Interactions between the Promoter Regions of Nitrogenase Structural Genes ( nifHDK2 ) and DNA-Binding Proteins from N 2 - and Ammonium-Grown Cells of the Archaeon Methanosarcina barkeri 227

Autor: John D. Helmann, Stephen H. Zinder, Yueh-Tyng Chien

Publikováno v: Journal of Bacteriology. 180:2723-2728

Transcription initiation in Archaea (archaebacteria) resembles the eucaryotic process, having been shown to involve TATA box-like promoter regions as well as TATA-binding protein and TFIIB homologs. However, little is known about transcription regula

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6c6a1ce67e52179ffb030f91d22e555e
https://doi.org/10.1128/jb.180.10.2723-2728.1998

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Molecular Interactions between Two Global Regulators, sar and agr, in Staphylococcus aureus

Autor: Yueh-tyng Chien, Ambrose L. Cheung

Publikováno v: Journal of Biological Chemistry. 273:2645-2652

The expression of many virulence determinants in Staphylococcus aureus is controlled by regulatory loci such as agr and sar. We have previously shown that the SarA protein is required for optimal transcription of RNAII and RNAIII in the agr locus. To

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1706d011ff4a1f0c0d5d679c39edb01f
https://doi.org/10.1074/jbc.273.5.2645

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Cloning, DNA sequencing, and characterization of a nifD-homologous gene from the archaeon Methanosarcina barkeri 227 which resembles nifD1 from the eubacterium Clostridium pasteurianum

Autor: Yueh-Tyng Chien, Stephen H. Zinder

Publikováno v: Journal of Bacteriology. 176:6590-6598

L. Sibold, M. Henriquet, O. Possot, and J.-P. Aubert (Res. Microbiol. 142:5-12, 1991) cloned and sequenced two nifH-homologous open reading frames (ORFs) from Methanosarcina barkeri 227. Phylogenetic analysis of the deduced amino acid sequences of th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92728e06165989c0b3347271c12cb38a
https://doi.org/10.1128/jb.176.21.6590-6598.1994

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