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A new class of bradykinin 1 receptor antagonists containing the piperidine acetic acid tetralin core
Autor:
David A. Mareska, Eileen Johnson, Christopher H. Fotsch, Dianna Lester-Zeiner, Qingyian Liu, Gloria Biddlecome, Gordon Ng, James Zhan, Kaustav Biswas, Nianhe Bruce Han, Yueh-Ju Judy Wang, Joe Zhu, Babak Riahi, Gondi N. Kumar, Kevin Yang, Robert D. Groneberg, Derin C. D'amico, Feng-Yin Hsieh, Jian Jeff Chen, Benny C. Askew, Augustus Kamassah
Publikováno v:
Bioorganicmedicinal chemistry letters. 16(8)
The bradykinin 1 (B1) receptor is upregulated during times of inflammation and is important for maintaining inflamed and chronic pain states. Blocking this receptor has been shown to reverse and/or ameliorate pain and inflammation in animal models. I
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5310f114bdf0cdb04629d50164f8f659
https://pubmed.ncbi.nlm.nih.gov/16464576
https://pubmed.ncbi.nlm.nih.gov/16464576
