Targeted Delivery of Plasminogen Activators for Thrombolytic Therapy: An Integrative Evaluation

Autor: Yunn-Hwa Ma, Chih-Hsin Liu, Yueh Liang, Jyh-Ping Chen, Tony Wu

Publikováno v: Molecules, Vol 24, Iss 18, p 3407 (2019)

In thrombolytic therapy, plasminogen activators (PAs) are still the only group of drug approved to induce thrombolysis, and therefore, critical for treatment of arterial thromboembolism, such as stroke, in the acute phase. Functionalized nanocomposit

Externí odkaz: https://doaj.org/article/ca986dc4b30941fa9b9ed375df14db5c

Eradicating mesothelin-positive human gastric and pancreatic tumors in xenograft models with optimized anti-mesothelin antibody–drug conjugates from synthetic antibody libraries

Autor: Hung-Ju Hsu, Chao-Ping Tung, Chung-Ming Yu, Chi-Yung Chen, Hong-Sen Chen, Yu-Chuan Huang, Pei-Hsun Tsai, Su-I Lin, Hung-Pin Peng, Yi-Kai Chiu, Yueh-Liang Tsou, Wei-Ying Kuo, Jhih-Wei Jian, Fei-Hung Hung, Chiao-Yun Hsieh, Michael Hsiao, Simon Shih-Hsien Chuang, Chia-Ning Shen, Yong Alison Wang, An-Suei Yang

Publikováno v: Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)

Abstract Mesothelin (MSLN) is an attractive candidate of targeted therapy for several cancers, and hence there are increasing needs to develop MSLN-targeting strategies for cancer therapeutics. Antibody–drug conjugates (ADCs) targeting MSLN have be

Externí odkaz: https://doaj.org/article/1fd9e8c33c85491783497a53a3cfc809

Eradicating mesothelin-positive human gastric and pancreatic tumors in xenograft models with optimized anti-mesothelin antibody–drug conjugates from synthetic antibody libraries

Autor: Michael Hsiao, Jhih-Wei Jian, Chiao-Yun Hsieh, Yong Alison Wang, Yueh-Liang Tsou, Chia-Ning Shen, Yu Chung-Ming, Hung-Ju Hsu, Hong-Sen Chen, Kuo Wei-Ying, Fei-Hung Hung, Tung Chao-Ping, Chi-Yung Chen, Hung-Pin Peng, Pei-Hsun Tsai, Simon Shih-Hsien Chuang, An-Suei Yang, Chiu Yi-Kai, Su-I Lin, Yu-Chuan Huang

Publikováno v: Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
Scientific Reports

Mesothelin (MSLN) is an attractive candidate of targeted therapy for several cancers, and hence there are increasing needs to develop MSLN-targeting strategies for cancer therapeutics. Antibody–drug conjugates (ADCs) targeting MSLN have been demons

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a483abbcadb81e6aa556a2671f32fb7e
https://doaj.org/article/1fd9e8c33c85491783497a53a3cfc809

Effective binding to protein antigens by antibodies from antibody libraries designed with enhanced protein recognition propensities

Autor: Ing-Chien Chen, Tung Chao-Ping, Hung-Pin Peng, Kuo Wei-Ying, Jhih-Wei Jian, Yu Chung-Ming, Chiu Yi-Kai, An-Suei Yang, Yueh-Liang Tsou, Hong-Sen Chen, Hung-Ju Hsu

Publikováno v: mAbs

Antibodies provide immune protection by recognizing antigens of diverse chemical properties, but elucidating the amino acid sequence-function relationships underlying the specificity and affinity of antibody-antigen interactions remains challenging.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bde0af14b3ae4daec1c789ae8710bc94
http://europepmc.org/articles/PMC6380391

Socioeconomic Status and Outcomes in Heart Failure With Reduced Ejection Fraction From Asia

Autor: Tiew-Hwa K. Teng, Wan Ting Tay, Arthur Mark Richards, Timothy Shi Ming Chew, Inder Anand, Wouter Ouwerkerk, Chanchal Chandramouli, Weiting Huang, Claire A. Lawson, Umesh T. Kadam, Jonathan Yap, Shirlynn Lim, Chung-Lieh Hung, Michael Ross MacDonald, Seet Yoong Loh, Wataru Shimizu, Jasper Tromp, Carolyn Su Ping Lam, Lieng Hsi Ling, Houng Bang Liew, Calambur Narasimhan, Tachapong Ngarmukos, Sang Weon Park, Eugenio Reyes, Bambang B. Siswanto, Shu Zhang, Xiaohan Fan, Keping Chen, Liqun Wu, Yucai Xie, Qi Jin, Tianyou Ling, Xinli Li, Fang Zhou, Yanli Zhou, Dongjie Xu, Haifeng Zhang, Yangang Su, Xueying Chen, Shengmei Qin, Jingfeng Wang, Xue Gong, Zhaodi Wu, Cheuk Man Yu, B K S Sastry, Arun Gopi, K Raghu, C Sridevi, Daljeet Kaur, Ajay Naik, Keyur Parikh, Anish Chandarana, Urmil Shah, Milan Chag, Hemang Baxi, Satya Gupta, Jyoti Bhatia, Vaishali Khakhkhar, Vineet Sankhla, Tejas Patel, Vipul Kapoor, Gurpreet Singh Wander, Rohit Tandon, Vijay Chopra, Manoj Kumar, Hatinder Jeet Singh Sethi, Rashmi Verma, Sanjay Mittal, Jitendra Sawhney, Manish Kr. Sharma, Mohanan Padinhare Purayil, Bambang Budi Siswanto, RS Dr Hasan Sadikin, Pintoko Tedjokusumo, Erwan Martanto, Muhammad Munawar, Jimmy Agung Pambudi, RS Siloam Karawaci, Antonia Lukito, Ingrid Pardede, Alvin Thengker, Vito Damay, Siska Suridanda Danny, Rarsari Surarso, Takashi Noda, Ikutaro Nakajima, Mitsuru Wada, Kohei Ishibashi, Takashi Kurita, Ryoubun Yasuoka, Kuniya Asai, Kohji Murai, Yoshiaki Kubota, Yuki Izumi, Takanori Ikeda, Shinji Hisatake, Takayuki Kabuki, Shunsuke Kiuchi, Nobuhisa Hagiwara, Atsushi Suzuki, Dr Tsuyoshi Suzuki, Sang-Weon Park, Suk Keun Hong, SookJin Lee, Lim Dal Soo, Dong-Hyeok Kim, Jaemin Shim, Seong-Mi Park, Seung-Young Roh, Young Hoon Kim, Mina Kim, Jong-Il Choi, Jin Oh Na, Seung Woon Rha, Hong Seog Seo, Dong Joo Oh, Chang Gyu Park, Eung Ju Kim, Sunki Lee, Boyoung Joung, Jae-Sun Uhm, Moon Hyoung Lee, In-Jeong Cho, Hui-Nam Park, Hyung-Wook Park, Jeong-Gwan Cho, Namsik Yoon, KiHong Lee, Kye Hun Kim, Seong Hwan Kim, Sahrin Saharudin, Boon Cong Beh, Yu Wei Lee, Chia How Yen, Mohd Khairi Othman, Amie-Anne Augustine, Mohd Hariz Mohd Asnawi, Roberto Angelo Mojolou, You Zhuan Tan, Aida Nurbaini Arbain, Chii Koh Wong, Razali Omar, Azmee Mohd Ghazi, Surinder Kaur Khelae, David S.P. Chew, Lok Bin Yap, Azlan Hussin, Zulkeflee Muhammad, Mohd. Ghazi Azmee, Imran Zainal Abidin, Ahmad Syadi Bin Mahmood Zhudi, Nor Ashikin Md Sari, Ganiga Srinivasaiah Sridhar, Ahmad Syadi Mahmood Zuhdi, Muhammad Dzafir Ismail, Tiong Kiam Ong, Yee Ling Cham, Ning Zan Khiew, Asri Bin Said, Alan Yean Yip Fong, Nor Hanim Mohd Amin, Keong Chua Seng, Sian Kong Tan, Kuan Leong Yew, Jones Santos, Allan Lim, Raul Lapitan, Ryan Andal, Eleanor Lopez, Kheng Leng David Sim, Boon Yew Tan, Choon Pin Lim, Louis L.Y. Teo, Laura L.H. Chan, Ping Chai, Ching Chiew Raymond Wong, Kian Keong Poh, Poh Shuan Daniel Yeo, Evelyn M. Lee, Min Er Ching, Deanna Z.L. Khoo, Min Sen Yew, Wenjie Huang, Kui Toh Gerard Leong, Jia Hao Jason See, Yaozong Benji Lim, Svenszeat Tan, Colin Yeo, Siang Chew Chai, Fazlur Rehman Jaufeerally, Haresh Tulsidas, Than Aung, Hean Yee Ong, Lee Fong Ling, Dinna Kar Nee Soon, Hung-I Yeh, Jen-Yuan Kuo, Chih-Hsuan Yen, Juey-Jen Hwang, Kuo-Liong Chien, Ta-Chen Su, Lian-Yu Lin, Jyh-Ming Juang, Yen-Hung Lin, Fu-Tien Chiang, Jiunn-Lee Lin, Yi-Lwun Ho, Chii-Ming Lee, Po-Chih Lin, Chi-Sheng Hung, Sheng-Nan Chang, Jou-Wei Lin, Chih-Neng Hsu, Wen-Chung Yu, Tze-Fan Chao, Shih-Hsien Sung, Kang-Ling Wang, Hsin-Bang Leu, Yenn-Jiang Lin, Shih-Lin Chang, Po-Hsun Huang, Li-Wei Lo, Cheng-Hsueh Wu, Hsin-Yueh Liang, Shih-Sheng Chang, Lien-Cheng Hsiao, Yu-Chen Wang, Chiung-Ray Lu, Hung-Pin Wu, Yen-Nien Lin, Ke-Wei Chen, Ping-Han Lo, Chung-Ho Hsu, Li-Chuan Hsieh, Mann Chandavimol, Teerapat Yingchoncharoen, Prasart Laothavorn, Waraporn Tiyanon, Wanwarang Wongcharoen, Arintaya Phrommintikul

Publikováno v: Circulation: Cardiovascular Quality and Outcomes, 14(4):006962. LIPPINCOTT WILLIAMS & WILKINS
Circulation. Cardiovascular quality and outcomes, 399-412. Lippincott Williams and Wilkins
STARTPAGE=399;ENDPAGE=412;ISSN=1941-7713;TITLE=Circulation. Cardiovascular quality and outcomes

Background: Little is known regarding the impact of socioeconomic factors on the use of evidence-based therapies and outcomes in patients with heart failure with reduced ejection fraction across Asia. Methods: We investigated the association of both

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b74d2bb0a2f3f70e9ac19cbdc216edc
https://doi.org/10.1161/circoutcomes.120.006962