Zobrazeno 1 - 10
of 70
pro vyhledávání: '"Yuefei Shen"'
Autor:
Jiajia Liao, Qinxin Zhang, Jinjun Huang, Honghu He, Jiang Lei, Yuefei Shen, Jin Wang, Yousheng Xiao
Publikováno v:
Frontiers in Neuroscience, Vol 17 (2023)
Parkinson’s disease (PD) is the second most prevalent neurodegenerative disease and the most common movement disorder. It involves a gradual loss of dopaminergic neurons in the substantia nigra. Although many studies have been conducted, the underl
Externí odkaz:
https://doaj.org/article/f94951fcf79a460a8c8e32120b4b6cfa
Autor:
Emmanouela Tsagkaraki, Sarah M. Nicoloro, Tiffany DeSouza, Javier Solivan-Rivera, Anand Desai, Lawrence M. Lifshitz, Yuefei Shen, Mark Kelly, Adilson Guilherme, Felipe Henriques, Nadia Amrani, Raed Ibraheim, Tomas C. Rodriguez, Kevin Luk, Stacy Maitland, Randall H. Friedline, Lauren Tauer, Xiaodi Hu, Jason K. Kim, Scot A. Wolfe, Erik J. Sontheimer, Silvia Corvera, Michael P. Czech
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
Worldwide pandemics of obesity and diabetes prompt an urgent need for new approaches to their prevention and cure. Here the authors present a CRISPR-based strategy that enhances the therapeutic potential of human adipocytes when implanted in obese mi
Externí odkaz:
https://doaj.org/article/9db95209ec9c4296b7f96552abbf9db0
Autor:
Hongming Liang, Wenyuan Guo, Honghu He, Hui Zhang, Qiongyu Ye, Qingxin Zhang, Jiajia Liao, Yuefei Shen, Jin Wang, Yousheng Xiao, Chao Qin
Publikováno v:
Frontiers in Neuroscience, Vol 16 (2022)
BackgroundRecently, the neurite outgrowth inhibitor-B (Nogo-B) receptor has been reported as a novel candidate gene for Parkinson's disease (PD). Nogo-B receptors need to combine with soluble Nogo-B to exert their physiological function. However, lit
Externí odkaz:
https://doaj.org/article/3b446b462acc4e4da496c2c20f9c8b2f
Autor:
Yousheng Xiao, Hongchang Chen, Jiajia Liao, Qinxin Zhang, Honghu He, Jiang Lei, Jinjun Huang, Qiang Ouyang, Yuefei Shen, Jin Wang
Publikováno v:
Frontiers in Neuroscience, Vol 16 (2022)
Parkinson’s disease (PD) is a progressive neurodegenerative disease. It has been reported that circular RNAs (circRNAs) play important roles in several neurological diseases. However, the role and regulatory networks of circRNAs in PD are still lar
Externí odkaz:
https://doaj.org/article/b413686ce5ed4847be6112bba2d0646e
Autor:
Jing Gan, Weiguo Liu, Xuebing Cao, Anmu Xie, Wentao Li, Canxing Yuan, Lirong Jin, Suzhi Liu, Lingjing Jin, Dengjun Guo, Yuefei Shen, Yuncheng Wu, Zhenguo Liu
Publikováno v:
Frontiers in Neurology, Vol 12 (2021)
Objectives: Freezing of gait (FOG) is generally considered as an independent symptom of Parkinson's disease (PD) with a complex pathophysiology. There is a wide range of associated clinical features of FOG reported from different studies without cons
Externí odkaz:
https://doaj.org/article/2049f58792504816ae20c61c6dbe5935
Autor:
Yanting Zhou, Xiaoting Ge, Yuefei Shen, Lian Qin, Yaoqiu Zhong, Chao Jiang, Cheng Su, Jinyu Huang, Suzhen Lin, Defu Li, Hong Cheng, Fu Wei, Songfeng Ou, Yunfeng Zou, Xiaobo Yang
Publikováno v:
BMC Public Health, Vol 18, Iss 1, Pp 1-9 (2018)
Abstract Background Long-term excess exposure to environmental manganese (Mn) can lead to multi-system damage, especially in occupational populations. Therefore, we established a manganese-exposed workers healthy cohort (MEWHC), focusing on the syste
Externí odkaz:
https://doaj.org/article/c127bb83f54c44618c021b104162d846
Autor:
Tony Jourdan, Sarah M. Nicoloro, Zhou Zhou, Yuefei Shen, Jie Liu, Nathan J. Coffey, Resat Cinar, Grzegorz Godlewski, Bin Gao, Myriam Aouadi, Michael P. Czech, George Kunos
Publikováno v:
Molecular Metabolism, Vol 6, Iss 11, Pp 1517-1528 (2017)
Objective: Obesity-induced accumulation of ectopic fat in the liver is thought to contribute to the development of insulin resistance, and increased activity of hepatic CB1R has been shown to promote both processes. However, lipid accumulation in liv
Externí odkaz:
https://doaj.org/article/6b8273e668b54647a023722675f906fc
Autor:
Adilson Guilherme, David J. Pedersen, Elizabeth Henchey, Felipe S. Henriques, Laura V. Danai, Yuefei Shen, Batuhan Yenilmez, DaeYoung Jung, Jason K. Kim, Irfan J. Lodhi, Clay F. Semenkovich, Michael P. Czech
Publikováno v:
Molecular Metabolism, Vol 6, Iss 8, Pp 781-796 (2017)
Background: The de novo biosynthesis of fatty acids (DNL) through fatty acid synthase (FASN) in adipocytes is exquisitely regulated by nutrients, hormones, fasting, and obesity in mice and humans. However, the functions of DNL in adipocyte biology an
Externí odkaz:
https://doaj.org/article/6bc9d2917df04eb3b86d55ef045f6e28
Autor:
Fenfen Wang, Yunfeng Zou, Yuefei Shen, Yaoqiu Zhong, Yingnan Lv, Damin Huang, Kangcheng Chen, Qin Li, Li Qing, Bing Xia, Cheng Su, Shuyan Ma, Xiaobo Yang
Publikováno v:
PLoS ONE, Vol 10, Iss 2, p e0116558 (2015)
The aims of this study were to investigate the effects of manganese (Mn) dust exposure on lung functions and evaluate the potential synergistic effect between smoking and Mn dust exposure among refinery workers.A retrospective study including 1658 wo
Externí odkaz:
https://doaj.org/article/de6abe4e375548eb8432d3863ce0321f
Autor:
Michael P. Czech, Tomás Rodríguez, Randall H. Friedline, Silvia Corvera, Raed Ibraheim, Lauren A. Tauer, Jason K. Kim, Kevin Luk, Sarah M. Nicoloro, Tiffany DeSouza, Lawrence M. Lifshitz, Anand Desai, Emmanouela Tsagkaraki, Xiaodi Hu, Felipe Henriques, Yuefei Shen, Nadia Amrani, Stacy Maitland, Mark J. S. Kelly, Scot A. Wolfe, Erik J. Sontheimer, Adilson L. Guilherme, Javier Solivan-Rivera
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
Nature Communications
Nature Communications
Obesity and type 2 diabetes are associated with disturbances in insulin-regulated glucose and lipid fluxes and severe comorbidities including cardiovascular disease and steatohepatitis. Whole body metabolism is regulated by lipid-storing white adipoc