Zobrazeno 1 - 10
of 340
pro vyhledávání: '"Yuedong Yang"'
Autor:
Jiahua Rao, Jiancong Xie, Qianmu Yuan, Deqin Liu, Zhen Wang, Yutong Lu, Shuangjia Zheng, Yuedong Yang
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-12 (2024)
Abstract Protein functions are characterized by interactions with proteins, drugs, and other biomolecules. Understanding these interactions is essential for deciphering the molecular mechanisms underlying biological processes and developing new thera
Externí odkaz:
https://doaj.org/article/15995af6663f46b18f7c2dec20cab4db
Publikováno v:
BMC Bioinformatics, Vol 25, Iss 1, Pp 1-17 (2024)
Abstract Background Predicting outcome of breast cancer is important for selecting appropriate treatments and prolonging the survival periods of patients. Recently, different deep learning-based methods have been carefully designed for cancer outcome
Externí odkaz:
https://doaj.org/article/a9125ce6a3d94537bb6feb129b385245
Autor:
Wei Jiang, Peng-Ying Wang, Qi Zhou, Qiu-Tong Lin, Yao Yao, Xun Huang, Xiaoming Tan, Shihui Yang, Weicai Ye, Yuedong Yang, Yun-Juan Bao
Publikováno v:
Journal of Translational Medicine, Vol 21, Iss 1, Pp 1-16 (2023)
Abstract Background With the development of cancer precision medicine, a huge amount of high-dimensional cancer information has rapidly accumulated regarding gene alterations, diseases, therapeutic interventions and various annotations. The informati
Externí odkaz:
https://doaj.org/article/5f3513a9400242d7b26c3281c88dee41
Publikováno v:
RNA Biology, Vol 20, Iss 1, Pp 431-443 (2023)
Recent studies suggest RNAs act as promising drug targets. However, limited development has been achieved in detecting RNA–ligand interactions. To guide the discovery of RNA-binding ligands, it is necessary to characterize them comprehensively, esp
Externí odkaz:
https://doaj.org/article/72d5faedea5f45bbbe0ffd576d07e323
Publikováno v:
Shipin gongye ke-ji, Vol 44, Iss 23, Pp 110-117 (2023)
The aim of this work was to apply response surface methodology (RSM) to model and optimize the accelerated solvent extraction (ASE) technique for extracting the crude polysaccharides (GLP-K) from Gracilaria lemaneiformis. In terms of the yield of pol
Externí odkaz:
https://doaj.org/article/eec2a583784047d0bd42918fd185b3d2
Publikováno v:
eLife, Vol 13 (2024)
Revealing protein binding sites with other molecules, such as nucleic acids, peptides, or small ligands, sheds light on disease mechanism elucidation and novel drug design. With the explosive growth of proteins in sequence databases, how to accuratel
Externí odkaz:
https://doaj.org/article/58a108748c8d4f408ffa65aa5e2a6346
Publikováno v:
Molecules, Vol 29, Iss 9, p 1996 (2024)
The wheat scab caused by Fusarium graminearum (F. graminearum) has seriously affected the yield and quality of wheat in China. In this study, gallic acid (GA), a natural polyphenol, was used to synthesize three azole-modified gallic acid derivatives
Externí odkaz:
https://doaj.org/article/1a1034f6cfbd4a7dbf49a69d73abc71f
Autor:
Siying Lin, Haoyang Zhang, Mengling Qi, David N. Cooper, Yuedong Yang, Yuanhao Yang, Huiying Zhao
Publikováno v:
NeuroImage, Vol 279, Iss , Pp 120325- (2023)
Observational studies consistently disclose brain imaging-derived phenotypes (IDPs) as critical markers for early diagnosis of both brain disorders and cardiovascular diseases. However, it remains unclear about the shared genetic landscape between br
Externí odkaz:
https://doaj.org/article/292dc4e1175d4209bdffb9d5b21807c2
Publikováno v:
iScience, Vol 26, Iss 9, Pp 107663- (2023)
Summary: The medicinal effect of a drug acts through a series of genes, and the pathological mechanism of a disease is also related to genes with certain biological functions. However, the complex information between drug or disease and a series of g
Externí odkaz:
https://doaj.org/article/796a4d86a3bd42fe894df590bc253709
Autor:
Chuwei Liu, Arabella H. Wan, Heng Liang, Lei Sun, Jiarui Li, Ranran Yang, Qinghai Li, Ruibo Wu, Kunhua Hu, Yuedong Yang, Shirong Cai, Guohui Wan, Weiling He
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 21, Iss , Pp 4540-4551 (2023)
Tumor mutation burden (TMB) has emerged as an essential biomarker for assessing the efficacy of cancer immunotherapy. However, due to the inherent complexity of tumors, TMB is not always correlated with the responsiveness of immune checkpoint inhibit
Externí odkaz:
https://doaj.org/article/c98c0952daaa4ce08c6716815fd5db9d