Zobrazeno 1 - 10
of 96
pro vyhledávání: '"Yuechen Han"'
Autor:
Junze Lu, Man Wang, Xue Wang, Yu Meng, Fang Chen, Jinzhu Zhuang, Yuechen Han, Haibo Wang, Wenwen Liu
Publikováno v:
Materials Today Bio, Vol 24, Iss , Pp 100937- (2024)
Spiral ganglion neurons (SGNs) in the mammalian cochleae are essential for the delivery of acoustic information, and damage to SGNs can lead to permanent sensorineural hearing loss as SGNs are not capable of regeneration. Cochlear glial cells (GCs) m
Externí odkaz:
https://doaj.org/article/8bb1ea2a41804f7b83ca234e6cdcbe88
Publikováno v:
Cell Death Discovery, Vol 8, Iss 1, Pp 1-14 (2022)
Abstract The transcription factor c-Myb is vital for cell survival, proliferation, differentiation, and apoptosis. We have previously reported that c-Myb knockdown exacerbates neomycin-induced damage to cochlea cells. However, the function and regula
Externí odkaz:
https://doaj.org/article/795849d9a27040c88b9b4819e69a5cb0
Publikováno v:
Journal of Otolaryngology - Head and Neck Surgery, Vol 50, Iss 1, Pp 1-6 (2021)
Abstract Background It was well-documented that extended high-frequency (EHF, above 8 kHz) hearing test could be more sensitive comparing with the conventional measurement on frequency below 8 kHz, regarding the early prediction of auditory damage in
Externí odkaz:
https://doaj.org/article/e25fdba2885f4467b927780ba38f69b7
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 16 (2022)
Glutathione peroxidase 1 (GPX1) is a crucial antioxidant enzyme that prevented the harmful accumulation of intra-cellular hydrogen peroxide. GPX1 might contribute in limiting cochlear damages associated with aging or acoustic overexposure, but the fu
Externí odkaz:
https://doaj.org/article/50b61236d42b435794d2476040a12b0e
Publikováno v:
BMC Surgery, Vol 21, Iss 1, Pp 1-10 (2021)
Abstract Background Early surgical repair to restore nerve integrity has become the most commonly practiced method for managing facial nerve injury. However, the evidence for the efficacy of surgical repair for restoring the function of facial nerves
Externí odkaz:
https://doaj.org/article/0d0d5755742d495198cdbdfff8e9791b
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 14 (2022)
In the mammalian cochlea, spiral ganglion neurons (SGNs) are the primary neurons on the auditory conduction pathway that relay sound signals from the inner ear to the brainstem. However, because the SGNs lack the regeneration ability, degeneration an
Externí odkaz:
https://doaj.org/article/68b14280d2f1496a8f79247fc31764eb
Autor:
He Li, Yongdong Song, Zuhong He, Xiaoyun Chen, Xianmin Wu, Xiaofei Li, Xiaohui Bai, Wenwen Liu, Boqin Li, Shanshan Wang, Yuechen Han, Lei Xu, Daogong Zhang, Jianfeng Li, Renjie Chai, Haibo Wang, Zhaomin Fan
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 12 (2018)
Hearing loss is the most common sensory disorder in humans, and a significant number of cases is due to the ototoxicity of drugs such as cisplatin that cause hair cell (HC) damage. Thus, there is great interest in finding agents and mechanisms that p
Externí odkaz:
https://doaj.org/article/fdbba4b74e8a4df0a77c692180f61667
Autor:
Gaoying Sun, Wenwen Liu, Zhaomin Fan, Daogong Zhang, Yuechen Han, Lei Xu, Jieyu Qi, Shasha Zhang, Bradley T. Gao, Xiaohui Bai, Jianfeng Li, Renjie Chai, Haibo Wang
Publikováno v:
Neural Plasticity, Vol 2016 (2016)
Whole organ culture of the spiral ganglion region is a resourceful model system facilitating manipulation and analysis of live sprial ganglion neurons (SGNs). Three-dimensional (3D) cultures have been demonstrated to have many biomedical applications
Externí odkaz:
https://doaj.org/article/687b6ce95584437db871d01e956f387e
Autor:
Wenqing Yan, Jianfeng Li, Renjie Chai, Wentao Guo, Lei Xu, Yuechen Han, Xiaohui Bai, Haibo Wang
Publikováno v:
PLoS ONE, Vol 9, Iss 10, p e111620 (2014)
In this study, using an Streptococcus pneumoniae-induced tympanosclerosis (TS) model, we explored the effects of captopril and losartan in the treatment of TS and the possible mechanisms.A prospective experimental animal study.We set up the TS models
Externí odkaz:
https://doaj.org/article/60caa7cb9623453d8665ae1a904a06ce
Autor:
qiongmin zhang, Zhiqun Yao, Fang Chen, Xue Wang, Man Wang, Junze Lu, Yu Meng, Lei Xu, Yuechen Han, Wenwen Liu, Haibo Wang
Publikováno v:
Molecular Neurobiology. 60:3788-3802
Teicoplanin, a glycopeptide antibiotic, is used for the treatment of severe staphylococcal infections. Teicoplanin is reported to have an ototoxic potential but its toxic effects on cochlea hair cells (HCs) remains unclear. TP53-induced glycolysis an