Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Yuebo Gan"'
Publikováno v:
Pharmaceutical Research. 23:1324-1331
Preclinical results indicate acidic fibroblast growth factor (aFGF) and basic FGF (bFGF) present in solid tumors as a cause of broad-spectrum chemoresistance, whereas earlier clinical studies suggest that bFGF expression is associated with opposing o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::518b5fa69b5dfb1cfec005e58dd6073d
https://doi.org/10.1007/s11095-006-0136-6
https://doi.org/10.1007/s11095-006-0136-6
Publikováno v:
Clinical Cancer Research. 11:4204-4211
Purpose: The present study evaluated the tissue distribution and targeting advantage of intraprostatic chemotherapy. Experimental Design: We studied the delivery and spatial distribution of a fluorescent drug, doxorubicin, in the prostate of beagle d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1595e955cd6fa34e986d0c76303035e
https://doi.org/10.1158/1078-0432.ccr-04-1969
https://doi.org/10.1158/1078-0432.ccr-04-1969
Publikováno v:
Pharmaceutical Research. 20:957-961
Purpose. We recently demonstrated simultaneous targeting of telomere and telomerase as a novel cancer therapeutic approach, and that telomerase inhibitors such as 3′azido-3′deoxythymidine (AZT) significantly enhanced the antitumor activity of pac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8506a2f9947ff34b8af1af9b0ebc4640
https://doi.org/10.1023/a:1024431218327
https://doi.org/10.1023/a:1024431218327
Autor:
Jie Lu, M. Guillaume Wientjes, Bertrand Z. Yeung, Yuebo Gan, Christopher T. Cottage, Jessie L.-S. Au
Publikováno v:
The AAPS journal. 17(1)
We reported that suramin is an effective chemosensitizer at noncytotoxic concentrations (60 μM for cytotoxicity), and continuous treatment at 10–25 μM for 6 weeks resulted in gradual telomere shortening (maximum of 30%) and cell senescence (measu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20177a4f479841921287106598968575
https://pubmed.ncbi.nlm.nih.gov/25425294
https://pubmed.ncbi.nlm.nih.gov/25425294
Publikováno v:
Pharmaceutical Research. 18:1655-1659
Purpose. Telomeres are specific DNA structure at the ends of chromosomes to protect chromosomes from fusion, recombination, and degradation. Telomere length changes are implicated in cell senescence, aging, tumorigenesis, and DNA repair. The standard
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::eefab6ea84304444c682132e3f7b0f60
https://doi.org/10.1023/a:1013306109801
https://doi.org/10.1023/a:1013306109801
Autor:
M. Guillaume Wientjes, David E. Schuller, Yuebo Gan, Andrew D. Johnson, Jie Lu, Jessie L.-S. Au
Publikováno v:
Pharmaceutical Research. 18:488-493
Purpose. Telomerase is a ribonucleoprotein that extends telomeres at the ends of chromosome. Increased telomerase activity is associated with cellular immortality. The currently available assay for telomerase, i.e., telomeric repeat amplification pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::224932b8ac3b4ccc27c4cea2cbb961a1
https://doi.org/10.1023/a:1011006427733
https://doi.org/10.1023/a:1011006427733
Publikováno v:
Cancer Chemotherapy and Pharmacology. 42:177-182
We have previously reported incomplete cytotoxic responses of other human solid tumors (bladder, head and neck, ovarian and prostate) to paclitaxel. This finding is qualitatively different from the nearly complete response observed in monolayer cultu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5bfccfef998c76899253ec0711228dd6
https://doi.org/10.1007/s002800050803
https://doi.org/10.1007/s002800050803
Publikováno v:
Pharmaceutical Research. 15:122-127
PURPOSE The present study evaluated the cytostatic and apoptotic effects of a 24-hr paclitaxel treatment in ovarian tumors. METHODS Three-dimensional histocultures of surgical specimens from patients (n = 17) were used. The cytostatic effect was meas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ef39d4f2ef4eb782855211909ec86f91
https://doi.org/10.1023/a:1011969208114
https://doi.org/10.1023/a:1011969208114
Publikováno v:
Pharmaceutical Research. 15:1760-1766
Purpose. We have shown that the three human prostate xenograft tumors, i.e. the androgen-dependent CWR22 tumor, and the androgen-resistant CWR22R and CWR91 tumors, are comparable to patient tumors in their expression of prostate specific antigen, mul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bdfe84dfaf73511cd36b274d1bffedc7
https://doi.org/10.1023/a:1011921031564
https://doi.org/10.1023/a:1011921031564
Publikováno v:
Pharmaceutical Research. 15:1546-1551
Purpose. The present study compared proliferative indices, i.e. incorporation of DNA precursor (i.e. thymidine or TdR, and bromodeoxyuridine or BrdU) and expression of proliferating cell nuclear antigen (PCNA), as molecular pharmacodynamic endpoints
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8793840aa69a874280d6d677a14f7be5
https://doi.org/10.1023/a:1011998932047
https://doi.org/10.1023/a:1011998932047