Zobrazeno 1 - 10
of 422
pro vyhledávání: '"Yue Ming Li"'
Autor:
Xixi Hou, Longfei Mao, Yajie Guo, Lan Wang, Lizeng Peng, Huili Wang, Jianxue Yang, Sanqiang Li, Yue-Ming Li
Publikováno v:
BMC Chemistry, Vol 18, Iss 1, Pp 1-12 (2024)
Abstract Modification of marketed drugs is an important way to develop drugs because its safety and clinical applicability. Oxygen-nitrogen heterocycles are a class of important active substances discovered in the process of new drug development. Dol
Externí odkaz:
https://doaj.org/article/d66191b3ae3d4647be1e806383cfcfa9
Autor:
Liwei Yang, Avery Ball, Jesse Liu, Tanya Jain, Yue-Ming Li, Firoz Akhter, Donghui Zhu, Jun Wang
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-11 (2022)
Current single-cell tools are limited by the number of proteins they can analyse. Here the authors report a single-cell cyclic multiplex in situ tagging (CycMIST) method for functional proteome profiling of single cells, allowing multiple rounds of m
Externí odkaz:
https://doaj.org/article/254800a5cc764106ac5c8d7ddb66a3ae
Autor:
Xiaojie Chen, Long-Fei Mao, Siqi Tian, Xueli Tian, Xueqiong Meng, Mu-Kuo Wang, Weifeng Xu, Yue-Ming Li, Kangdong Liu, Zigang Dong
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Previous report showed that a variety of icotinib derivatives bearing different 1,2,3-triazole moieties, which could be readily prepared via copper (I)-catalyzed cycloaddition (CuAAC) reaction between icotinib and different azides, exhibited interest
Externí odkaz:
https://doaj.org/article/c9faeb1fd23c406d9546abed11562efa
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Nineteen erlotinib derivatives bearing different 1,2,3-triazole moieties were designed, synthesized, and evaluated for their potential against different cancer cell lines. The structures of the synthesized compounds were confirmed via1H NMR, 13C NMR,
Externí odkaz:
https://doaj.org/article/61b2911d170c49a9976383264c7eac6c
Publikováno v:
The Journal of Organic Chemistry. 88:3046-3053
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7bc39eb6d27c75bd6c5d3d457cbb89ff
https://doi.org/10.1021/acs.joc.2c02749
https://doi.org/10.1021/acs.joc.2c02749
Publikováno v:
Frontiers in Aging Neuroscience, Vol 12 (2020)
Described as the “proteasome of the membrane” or the “scissors in the membrane,” γ-secretase has notoriously complicated biology, and even after decades of research, the full extent of its regulatory mechanism remains unclear. γ-Secretase i
Externí odkaz:
https://doaj.org/article/5217a41ed0cf4fe686aa2f27a9ac2a4d
Publikováno v:
Organic & Biomolecular Chemistry. 21:1764-1770
Up to 96% yields and up to 92% ee were achieved in enantioselective Michael addition of malonates to β,γ-unsaturated α-ketoesters catalysed by copper(ii) complexes bearing binaphthyl–proline hybrid ligands.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f8d18cea2a43ff9955e3438a202cde11
https://doi.org/10.1039/d2ob02305a
https://doi.org/10.1039/d2ob02305a
Publikováno v:
Frontiers in Pharmacology, Vol 11 (2020)
Tumor immunotherapy is considered to be a highlight in cancer treatment in recent years. Indoleamine 2,3-dioxygenase 1 (IDO1) is closely related to the over expression of many cancers, and is therefore a promising target for tumor immunotherapy. To s
Externí odkaz:
https://doaj.org/article/65879cc8421444bba470c0e4e6d371db
Autor:
Yue-Ming, Li, Yue-Min, Zhu, Lan-Mei, Gao, Ze-Wen, Han, Xiao-Jie, Chen, Chuan, Yan, Rong-Ping, Ye, Dai-Rong, Cao
Publikováno v:
World Journal of Gastroenterology. 28:2733-2747
The prognosis of hepatocellular carcinoma (HCC) remains poor and relapse occurs in more than half of patients within 2 years after hepatectomy. In terms of recent studies, microvascular invasion (MVI) is one of the potential predictors of recurrence.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6914efd69b2674361bbc725b24a04ba6
https://doi.org/10.3748/wjg.v28.i24.2733
https://doi.org/10.3748/wjg.v28.i24.2733
Autor:
Courtney Alexander, Thomas Li, Yorito Hattori, Danica Chiu, Georgia R. Frost, Lauren Jonas, Chenge Liu, Corey J. Anderson, Eitan Wong, Laibaik Park, Costantino Iadecola, Yue-Ming Li
Publikováno v:
Mol Psychiatry
Hypoxic-ischemic injury has been linked with increased risk for developing Alzheimer’s disease (AD). The underlying mechanism of this association is poorly understood. Here, we report distinct roles for hypoxia-inducible factor-1α (Hif-1α) in the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ffa4223a3233465412672a58fc73136f
https://doi.org/10.1038/s41380-022-01676-7
https://doi.org/10.1038/s41380-022-01676-7