Zobrazeno 1 - 10
of 423
pro vyhledávání: '"Yue Ming Li"'
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-16 (2024)
Abstract Variable thickness plates are relatively common structure in large-scale transportation equipment such as aerospace and ships. Due to their high running speed and large structural dimensions, such structures are usually induced high-frequenc
Externí odkaz:
https://doaj.org/article/490fe13b39df44469e0a595e0b156eef
Autor:
Xixi Hou, Longfei Mao, Yajie Guo, Lan Wang, Lizeng Peng, Huili Wang, Jianxue Yang, Sanqiang Li, Yue-Ming Li
Publikováno v:
BMC Chemistry, Vol 18, Iss 1, Pp 1-12 (2024)
Abstract Modification of marketed drugs is an important way to develop drugs because its safety and clinical applicability. Oxygen-nitrogen heterocycles are a class of important active substances discovered in the process of new drug development. Dol
Externí odkaz:
https://doaj.org/article/d66191b3ae3d4647be1e806383cfcfa9
Autor:
Liwei Yang, Avery Ball, Jesse Liu, Tanya Jain, Yue-Ming Li, Firoz Akhter, Donghui Zhu, Jun Wang
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-11 (2022)
Current single-cell tools are limited by the number of proteins they can analyse. Here the authors report a single-cell cyclic multiplex in situ tagging (CycMIST) method for functional proteome profiling of single cells, allowing multiple rounds of m
Externí odkaz:
https://doaj.org/article/254800a5cc764106ac5c8d7ddb66a3ae
Autor:
Joanna E. Luo, Yue-Ming Li
Publikováno v:
Cell & Bioscience, Vol 12, Iss 1, Pp 1-12 (2022)
Abstract Alzheimer’s disease (AD) is the most common type of neurodegenerative disorder. Amyloid-beta (Aβ) plaques are integral to the “amyloid hypothesis,” which states that the accumulation of Aβ peptides triggers a cascade of pathological
Externí odkaz:
https://doaj.org/article/8fb3390d8de5452a82c05f06ff1f3160
Autor:
Xiaojie Chen, Long-Fei Mao, Siqi Tian, Xueli Tian, Xueqiong Meng, Mu-Kuo Wang, Weifeng Xu, Yue-Ming Li, Kangdong Liu, Zigang Dong
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Previous report showed that a variety of icotinib derivatives bearing different 1,2,3-triazole moieties, which could be readily prepared via copper (I)-catalyzed cycloaddition (CuAAC) reaction between icotinib and different azides, exhibited interest
Externí odkaz:
https://doaj.org/article/c9faeb1fd23c406d9546abed11562efa
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Nineteen erlotinib derivatives bearing different 1,2,3-triazole moieties were designed, synthesized, and evaluated for their potential against different cancer cell lines. The structures of the synthesized compounds were confirmed via1H NMR, 13C NMR,
Externí odkaz:
https://doaj.org/article/61b2911d170c49a9976383264c7eac6c
Publikováno v:
Open Biology, Vol 12, Iss 1 (2022)
Alzheimer's disease (AD) is characterized by the presence of amyloid beta (Aβ) plaques and neurofibrillary tangles (NFTs), neuronal and synaptic loss and inflammation of the central nervous system (CNS). The majority of AD research has been dedicate
Externí odkaz:
https://doaj.org/article/9d483faa9dc14c669440c6c74b81943c
Publikováno v:
Frontiers in Aging Neuroscience, Vol 12 (2020)
Described as the “proteasome of the membrane” or the “scissors in the membrane,” γ-secretase has notoriously complicated biology, and even after decades of research, the full extent of its regulatory mechanism remains unclear. γ-Secretase i
Externí odkaz:
https://doaj.org/article/5217a41ed0cf4fe686aa2f27a9ac2a4d
Publikováno v:
The Journal of Organic Chemistry. 88:3046-3053
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7bc39eb6d27c75bd6c5d3d457cbb89ff
https://doi.org/10.1021/acs.joc.2c02749
https://doi.org/10.1021/acs.joc.2c02749
Publikováno v:
Organic & Biomolecular Chemistry. 21:1764-1770
Up to 96% yields and up to 92% ee were achieved in enantioselective Michael addition of malonates to β,γ-unsaturated α-ketoesters catalysed by copper(ii) complexes bearing binaphthyl–proline hybrid ligands.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f8d18cea2a43ff9955e3438a202cde11
https://doi.org/10.1039/d2ob02305a
https://doi.org/10.1039/d2ob02305a