Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Yue, Webster"'
Autor:
Sean G. Buchanan, James R. Henry, Robert M. Campbell, Christoph Reinhard, Gregory D. Plowman, David A. Barda, Xiang S. Ye, Hui-Rong Qian, Shaoyou Chu, Thompson Doman, Matthew Z. Dieter, Yu-Hua Hui, Scott W. Eastman, María José Lallena, Carmen Baquero, Carlos Marugán, Michele Dowless, Stephen R. Wasserman, Kenneth Weichert, Anna Pustilnik, Danalyn Manglicmot, Karen Froning, Ann M. Mc Nulty, Stephen Antonysamy, Avnish Kapoor, Li Fan, Chris Ficklin, Huimin Bian, Sufang Yao, Shaoling Jin, Bomie Han, Wayne Blosser, Xi Lin, Robert D. Van Horn, Li-Chun Chio, Philip W. Iversen, Yue Webster, Farhana F. Merzoug, Stephen H. Parsons, Jian Du, Xueqian Gong
LY3295668 chemical characterization
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::459c3119cab021ba3189b2c2e7d96d2e
https://doi.org/10.1158/2159-8290.22533034.v1
https://doi.org/10.1158/2159-8290.22533034.v1
Autor:
Sean G. Buchanan, James R. Henry, Robert M. Campbell, Christoph Reinhard, Gregory D. Plowman, David A. Barda, Xiang S. Ye, Hui-Rong Qian, Shaoyou Chu, Thompson Doman, Matthew Z. Dieter, Yu-Hua Hui, Scott W. Eastman, María José Lallena, Carmen Baquero, Carlos Marugán, Michele Dowless, Stephen R. Wasserman, Kenneth Weichert, Anna Pustilnik, Danalyn Manglicmot, Karen Froning, Ann M. Mc Nulty, Stephen Antonysamy, Avnish Kapoor, Li Fan, Chris Ficklin, Huimin Bian, Sufang Yao, Shaoling Jin, Bomie Han, Wayne Blosser, Xi Lin, Robert D. Van Horn, Li-Chun Chio, Philip W. Iversen, Yue Webster, Farhana F. Merzoug, Stephen H. Parsons, Jian Du, Xueqian Gong
shRNA suppressor screening data for H446 and MDA-MB-468 cells (tabs 1, 2) and RNA expression level associations with LY3295668 Abs IC50 values from 493 cancer cell lines (tab 3).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f7062b69c7f18848d7e882885812c96
https://doi.org/10.1158/2159-8290.22533025.v1
https://doi.org/10.1158/2159-8290.22533025.v1
Autor:
Sean G. Buchanan, James R. Henry, Robert M. Campbell, Christoph Reinhard, Gregory D. Plowman, David A. Barda, Xiang S. Ye, Hui-Rong Qian, Shaoyou Chu, Thompson Doman, Matthew Z. Dieter, Yu-Hua Hui, Scott W. Eastman, María José Lallena, Carmen Baquero, Carlos Marugán, Michele Dowless, Stephen R. Wasserman, Kenneth Weichert, Anna Pustilnik, Danalyn Manglicmot, Karen Froning, Ann M. Mc Nulty, Stephen Antonysamy, Avnish Kapoor, Li Fan, Chris Ficklin, Huimin Bian, Sufang Yao, Shaoling Jin, Bomie Han, Wayne Blosser, Xi Lin, Robert D. Van Horn, Li-Chun Chio, Philip W. Iversen, Yue Webster, Farhana F. Merzoug, Stephen H. Parsons, Jian Du, Xueqian Gong
Supplementary figures
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::071e82c7fa2f25274a31dc41f9817c55
https://doi.org/10.1158/2159-8290.22533037
https://doi.org/10.1158/2159-8290.22533037
Autor:
Louis Stancato, Peter Houghton, Sean Buchanan, Xueqian Gong, Jonathan B. Olsen, Philip Iversen, Philip Ebert, Alle B. VanWye, Jack Dempsey, Yue Webster, Julie Stewart, Simone Gupta, Wayne Blosser, Robert Flack, Jennifer Stephens, Matthew Renschler, Terry Shackleford, Caitlin D. Lowery, Michele Dowless
Supplementary Tables S1-S3, Figures S1-S4
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::036402dbac2178ab68e7cff483293ae3
https://doi.org/10.1158/1078-0432.22470711
https://doi.org/10.1158/1078-0432.22470711
Autor:
Louis Stancato, Peter Houghton, Sean Buchanan, Xueqian Gong, Jonathan B. Olsen, Philip Iversen, Philip Ebert, Alle B. VanWye, Jack Dempsey, Yue Webster, Julie Stewart, Simone Gupta, Wayne Blosser, Robert Flack, Jennifer Stephens, Matthew Renschler, Terry Shackleford, Caitlin D. Lowery, Michele Dowless
Purpose:Ewing sarcoma (ES) is a rare and highly malignant cancer that occurs in the bone and surrounding tissue of children and adolescents. The EWS/ETS fusion transcription factor that drives ES pathobiology was previously demonstrated to modulate c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2123f2418816e146f9f13a60e21f128f
https://doi.org/10.1158/1078-0432.c.6527661
https://doi.org/10.1158/1078-0432.c.6527661
Autor:
Samuel McNeely, Xin Tian You, Ann M. McNulty, Sean Buchanan, Wayne Blosser, Yue Webster, Gregory P. Donoho, Farhana F. Merzoug, Ricardo Martinez, Philip J. Ebert, Karsten Boehnke, Aimee Bence Lin, Xi Rao, Philip W. Iversen, Xueqian Gong, Richard P. Beckmann, Wenjuan Wu, Jack A. Dempsey, Chunping Yu, Caitlin D. Lowery
Publikováno v:
Oncotarget
The combined influence of oncogenic drivers, genomic instability, and/or DNA damage repair deficiencies increases replication stress in cancer. Cells with high replication stress rely on the upregulation of checkpoints like those governed by CHK1 for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92fdf2523c5cbc32f54448b3d0af1856
https://doi.org/10.18632/oncotarget.27400
https://doi.org/10.18632/oncotarget.27400
Autor:
Xueqian Gong, Karsten Boehnke, Carmen Baquero, Yue-Wei Qian, Gregory P. Donoho, Jason Manro, Robert T. Foreman, Carlos Marugán, Sonya C. Chapman, Yi Zeng, Phillip W Iversen, Jack A. Dempsey, Matthew Z. Dieter, David Anthony Barda, Henry James Robert, Michele Dowless, Shripad V. Bhagwat, Robert M. Campbell, Andrew Capen, Robert D. Van Horn, Amit Aggarwal, Mark S. Marshall, Darlene S. Barnard, Bharvin K. R. Patel, Louis Stancato, Huimin Bian, Li-Chun Chio, Sean Buchanan, Jian Du, Richard P. Beckmann, Christoph Reinhard, Ricardo Martinez, Gregory D. Plowman, Lei Yan, Shobha N. Bhattachar, Sarah M. Bogner, Maria Jose Lallena, Xiang S. Ye, Jennie L. Walgren, Yu-Hua Hui, Yue Webster, Emiko L. Kreklau, Raquel Torres, Yanzhu Yang, Bartley W. Halstead, Shaoyou Chu
Publikováno v:
Molecular Cancer Therapeutics. 18:2207-2219
Although Aurora A, B, and C kinases share high sequence similarity, especially within the kinase domain, they function distinctly in cell-cycle progression. Aurora A depletion primarily leads to mitotic spindle formation defects and consequently prom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ea271aab24607f19770d2cdca75d5d3
https://doi.org/10.1158/1535-7163.mct-18-0529
https://doi.org/10.1158/1535-7163.mct-18-0529
Autor:
Steven J. Kunnen, Marije Niemeijer, Giulia Callegaro, Laura I. Furlong, Jeffrey J. Sutherland, Janet Piñero Gonzalez, Wouter den Hollander, Panuwat Trairatphisan, Bob van de Water, Yue Webster, Emre Guney, James L. Stevens, Julio Saez-Rodriguez, Jennifer Mollon, Solène Grosdidier
Publikováno v:
Archives of Toxicology, 95(12), 3745-3775. Springer-Verlag
Archives of Toxicology
Archives of Toxicology, 95(12), 3745-3775
Archives of Toxicology
Archives of Toxicology, 95(12), 3745-3775
Mechanism-based risk assessment is urged to advance and fully permeate into current safety assessment practices, possibly at early phases of drug safety testing. Toxicogenomics is a promising source of mechanisms-revealing data, but interpretative an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cae839152101c7c0d415360667759ecf
https://pure.eur.nl/en/publications/b57c4814-0350-4abf-9941-fb822553e7c6
https://pure.eur.nl/en/publications/b57c4814-0350-4abf-9941-fb822553e7c6
Autor:
Yue Webster, Jeffrey J. Sutherland, Kamin J. Johnson, James L. Stevens, Bradley J. Mills, Daniel H. Robertson, Navin Elango
Publikováno v:
Toxicological Sciences
Applying toxicogenomics to improving the safety profile of drug candidates and crop protection molecules is most useful when it identifies relevant biological and mechanistic information that highlights risks and informs risk mitigation strategies. P
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e20b77e0f1f84a2d1da41b85b3c2475
https://doi.org/10.1093/toxsci/kfz101
https://doi.org/10.1093/toxsci/kfz101
Autor:
Xueqian Gong, Jian Du, Stephen H. Parsons, Farhana F. Merzoug, Yue Webster, Philip W. Iversen, Li-Chun Chio, Robert D. Van Horn, Xi Lin, Wayne Blosser, Bomie Han, Shaoling Jin, Sufang Yao, Huimin Bian, Chris Ficklin, Li Fan, Avnish Kapoor, Stephen Antonysamy, Ann M. Mc Nulty, Karen Froning, Danalyn Manglicmot, Anna Pustilnik, Kenneth Weichert, Stephen R. Wasserman, Michele Dowless, Carlos Marugán, Carmen Baquero, María José Lallena, Scott W. Eastman, Yu-Hua Hui, Matthew Z. Dieter, Thompson Doman, Shaoyou Chu, Hui-Rong Qian, Xiang S. Ye, David A. Barda, Gregory D. Plowman, Christoph Reinhard, Robert M. Campbell, James R. Henry, Sean G. Buchanan
Publikováno v:
Cancer Discovery. 9:248-263
Loss-of-function mutations in the retinoblastoma gene RB1 are common in several treatment-refractory cancers such as small-cell lung cancer and triple-negative breast cancer. To identify drugs synthetic lethal with RB1 mutation (RB1mut), we tested 36
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::872b67ff8b99d70e8dd283c21bc27cf8
https://doi.org/10.1158/2159-8290.cd-18-0469
https://doi.org/10.1158/2159-8290.cd-18-0469