Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Yudou, He"'
Autor:
Maria Zhivagui, Areebah Hoda, Noelia Valenzuela, Yi-Yu Yeh, Jason Dai, Yudou He, Shuvro P. Nandi, Burcak Otlu, Bennett Van Houten, Ludmil B. Alexandrov
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
Nail polish dryers commonly emit ultraviolet A (UVA) light, but the effects of this irradiation on mammalian cells remain unclear. Here, the authors examine the effects of UVA irradiation by a nail polish dryer on the genomes of mammalian cell lines,
Externí odkaz:
https://doaj.org/article/2c6c07a729a443be94d04a7debf38b91
Autor:
Pradipta Ghosh, Vinicius J. Campos, Daniella T. Vo, Caitlin Guccione, Vanae Goheen-Holland, Courtney Tindle, Guilherme S. Mazzini, Yudou He, Ludmil B. Alexandrov, Scott M. Lippman, Richard R. Gurski, Soumita Das, Rena Yadlapati, Kit Curtius, Debashis Sahoo
Publikováno v:
JCI Insight, Vol 7, Iss 18 (2022)
Although Barrett’s metaplasia of the esophagus (BE) is the only known precursor lesion to esophageal adenocarcinomas (EACs), drivers of cellular transformation in BE remain incompletely understood. We use an artificial intelligence–guided network
Externí odkaz:
https://doaj.org/article/21ff546cb1ee4b7dbd9d38e14d4d1128
Autor:
Maria Zhivagui, Areebah Hoda, Noelia Valenzuela, Yi-Yu Yeh, Jason Dai, Yudou He, Shuvro P. Nandi, Burcak Otlu, Bennett Van Houten, Ludmil B. Alexandrov
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-1 (2023)
Externí odkaz:
https://doaj.org/article/e7d53443ff974bf9958b92bb10480497
Syngeneic animal models of tobacco-associated oral cancer reveal the activity of in situ anti-CTLA-4
Autor:
Zhiyong Wang, Victoria H. Wu, Michael M. Allevato, Mara Gilardi, Yudou He, Juan Luis Callejas-Valera, Lynn Vitale-Cross, Daniel Martin, Panomwat Amornphimoltham, James Mcdermott, Bryan S. Yung, Yusuke Goto, Alfredo A. Molinolo, Andrew B. Sharabi, Ezra E. W. Cohen, Qianming Chen, J. Guy Lyons, Ludmil B. Alexandrov, J. Silvio Gutkind
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
Tobacco use is one of the major risk factors for Head and neck squamous cell carcinoma (HNSCC). Here, the authors report an immune-competent syngeneic mouse model that mimics human tobacco-related HNSCC, and develops tumors in the tongue, and report
Externí odkaz:
https://doaj.org/article/3fd2a00b6d274d9893b38fa9d6f2e131
Autor:
Jens Luebeck, Alvin Wei Tian Ng, Patricia C. Galipeau, Xiaohong Li, Carissa A. Sanchez, Annalise C. Katz-Summercorn, Hoon Kim, Sriganesh Jammula, Yudou He, Scott M. Lippman, Roel G. W. Verhaak, Carlo C. Maley, Ludmil B. Alexandrov, Brian J. Reid, Rebecca C. Fitzgerald, Thomas G. Paulson, Howard Y. Chang, Sihan Wu, Vineet Bafna, Paul S. Mischel
Publikováno v:
Luebeck, J, Ng, A W T, Galipeau, P C, Li, X, Sanchez, C A, Katz-Summercorn, A C, Kim, H, Jammula, S, He, Y, Lippman, S M, Verhaak, R G W, Maley, C C, Alexandrov, L B, Reid, B J, Fitzgerald, R C, Paulson, T G, Chang, H Y, Wu, S, Bafna, V & Mischel, P S 2023, ' Extrachromosomal DNA in the cancerous transformation of Barrett’s oesophagus ', Nature, vol. 616, no. 7958, pp. 798-805 . https://doi.org/10.1038/s41586-023-05937-5
Nature, 616(7958), 798-805. Nature Publishing Group
Nature, 616(7958), 798-805. Nature Publishing Group
Oncogene amplification on extrachromosomal DNA (ecDNA) drives the evolution of tumours and their resistance to treatment, and is associated with poor outcomes for patients with cancer1–6. At present, it is unclear whether ecDNA is a later manifesta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b79f4c574e7c40779822effa0cc3bcc
http://www.scopus.com/inward/record.url?scp=85152435510&partnerID=8YFLogxK
http://www.scopus.com/inward/record.url?scp=85152435510&partnerID=8YFLogxK
Autor:
S M Ashiqul Islam, Irina I. Abnizova, James McKay, Yudou He, Estelle Chanudet, Behnoush Abedi-Ardekani, Dariush Nasrollahzadeh, Michael Eden, Alisa M. Goldstein, Jon W. Teague, Blandina T. Mmbaga, Nan Hu, Karl Smith-Byrne, Sandra Perdomo, Jingwei Wang, Christine Carreira, Jean-Yves Scoazec, Rebecca C. Fitzgerald, Luis Felipe Ribeiro, Michael R. Stratton, Samad Gharavi, Sergey Senkin, Erik N Bergstrom, Hiva Saffar, Sarah Moody, Sheila Coelho Soares-Lima, Pauline E Bucciarelli, Stefano Serra, Ghislaine Scelo, Charles Dzamalala, Valerie McCormack, Reza Malekzadeh, Hossein Poustchi, Valerie Gaborieau, Lia S Campos, Joshua R. Atkins, Paul Brennan, Emily Thomas, David T. Jones, Paul Richman, Farid Azmoudeh-Ardalan, Masoud Sotoudeh, Ahmadreza Niavarani, Tatsuhiro Shibata, Calli Latimer, Stephen Fitzgerald, Ludmil B Alexandrov, Ricardo Cortez Cardoso Penha, Abdolreza Fazel, Laura Humphreys, Azhar Khandekar, Arash Nikmanesh, Diana Menya
Publikováno v:
Nature Genetics. 53:1553-1563
Esophageal squamous cell carcinoma (ESCC) shows remarkable variation in incidence that is not fully explained by known lifestyle and environmental risk factors. It has been speculated that an unknown exogenous exposure(s) could be responsible. Here w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66b1022f330ee49ffe06d2fa49c29076
https://doi.org/10.1038/s41588-021-00928-6
https://doi.org/10.1038/s41588-021-00928-6
Autor:
S.M. Ashiqul Islam, Marcos Díaz-Gay, Yang Wu, Mark Barnes, Raviteja Vangara, Erik N. Bergstrom, Yudou He, Mike Vella, Jingwei Wang, Jon W. Teague, Peter Clapham, Sarah Moody, Sergey Senkin, Yun Rose Li, Laura Riva, Tongwu Zhang, Andreas J. Gruber, Christopher D. Steele, Burçak Otlu, Azhar Khandekar, Ammal Abbasi, Laura Humphreys, Natalia Syulyukina, Samuel W. Brady, Boian S. Alexandrov, Nischalan Pillay, Jinghui Zhang, David J. Adams, Iñigo Martincorena, David C. Wedge, Maria Teresa Landi, Paul Brennan, Michael R. Stratton, Steven G. Rozen, Ludmil B. Alexandrov
Publikováno v:
Cell genomics, vol 2, iss 11
Mutational signature analysis is commonly performed in cancer genomic studies. Here, we present SigProfilerExtractor, an automated tool for de novo extraction of mutational signatures, and benchmark it against another 13 bioinformatics tools by using
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d66650f68920d43fde2ce688d861fe80
https://escholarship.org/uc/item/9b82739r
https://escholarship.org/uc/item/9b82739r
Autor:
Jens Luebeck, Alvin Wei Tian Ng, Patricia C. Galipeau, Xiaohong Li, Carissa A. Sanchez, Annalise Katz-Summercorn, Hoon Kim, Sriganesh Jammula, Yudou He, Scott M. Lippman, Roel Verhaak, Carlo C. Maley, Ludmil B. Alexandrov, Brian J. Reid, Rebecca C. Fitzgerald, Thomas G. Paulson, Howard Y. Chang, Sihan Wu, Vineet Bafna, Paul S. Mischel
BACKGROUNDOncogenes are commonly amplified on extrachromosomal DNA (ecDNA) contributing to poor outcomes for patients. Currently, the chronology of ecDNA development is not known. We studied the origination and evolution of ecDNA in patients with Bar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3437c31838450830e278588ad7f0412c
https://doi.org/10.1101/2022.07.25.501144
https://doi.org/10.1101/2022.07.25.501144
Autor:
Maria Zhivagui, Areebah Hoda, Noelia Valenzuela, Yi-yu Yeh, Jason Dai, Yudou He, Shuvro P. Nandi, Burcak Otlu, Bennett Van Houten, Ludmil Alexandrov
Publikováno v:
Cancer Research. 83:LB059-LB059
Ultraviolet A (UVA) rays are long wavelengths that can penetrate the deeper layer of the skin and are responsible for the immediate tanning effect. A multitude of natural and artificial sources of UV exposure exist, including UV-emitting lamps that a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6dc2afea48e4e7687c01dea830f2db86
https://doi.org/10.1158/1538-7445.am2023-lb059
https://doi.org/10.1158/1538-7445.am2023-lb059
Autor:
Jens Luebeck, Alvin W. Ng, Patricia C. Galipeau, Xiaohong Li, Annalise Katz-Summercorn, Hoon Kim, Sriganesh Jammula, Yudou He, Roel Verhaak, Carlo C. Maley, Ludmil B. Alexandrov, Rebecca C. Fitzgerald, Thomas G. Paulson, Howard Y. Chang, Sihan Wu, Vineet Bafna, Paul S. Mischel
Publikováno v:
Cancer Research. 83:3130-3130
Oncogene amplification on extrachromosomal DNA (ecDNA) drives rapid tumor evolution, treatment resistance, and poor outcomes for patients. Computational tools can detect ecDNA in whole-genome sequencing (WGS) data from biopsies. However, the lack of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bd262d383dfabaf646d002525de741eb
https://doi.org/10.1158/1538-7445.am2023-3130
https://doi.org/10.1158/1538-7445.am2023-3130