Výsledky vyhledávání - "Yudith Ramos Valdes"

Akademický článek

Gain-of-function p53R175H blocks apoptosis in a precursor model of ovarian high-grade serous carcinoma

Autor: Jacob Haagsma, Bart Kolendowski, Adrian Buensuceso, Yudith Ramos Valdes, Gabriel E. DiMattia, Trevor G. Shepherd

Publikováno v: Scientific Reports, Vol 13, Iss 1, Pp 1-14 (2023)

Abstract Ovarian high-grade serous carcinoma (HGSC) is a highly lethal malignancy for which early detection is a challenge and treatment of late-stage disease is ineffective. HGSC initiation involves exfoliation of fallopian tube epithelial (FTE) cel

Externí odkaz: https://doaj.org/article/ad1278351c7a4573a46854595d9528d2

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Akademický článek

Spatial and temporal epithelial ovarian cancer cell heterogeneity impacts Maraba virus oncolytic potential

Autor: Jessica G. Tong, Yudith Ramos Valdes, Milani Sivapragasam, John W. Barrett, John C. Bell, David Stojdl, Gabriel E. DiMattia, Trevor G. Shepherd

Publikováno v: BMC Cancer, Vol 17, Iss 1, Pp 1-13 (2017)

Abstract Background Epithelial ovarian cancer exhibits extensive interpatient and intratumoral heterogeneity, which can hinder successful treatment strategies. Herein, we investigated the efficacy of an emerging oncolytic, Maraba virus (MRBV), in an

Externí odkaz: https://doaj.org/article/6a1cbebf497f445e8c0b199b1dcd720a

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Akademický článek

Characterization of Mutational Status, Spheroid Formation, and Drug Response of a New Genomically-Stable Human Ovarian Clear Cell Carcinoma Cell Line, 105C

Autor: Bart Kolendowski, Yudith Ramos Valdes, Hal Hirte, Hiroaki Itamochi, Wonjae Lee, Mark Carey, Trevor G. Shepherd, Gabriel E. DiMattia

Publikováno v: Cells, Vol 9, Iss 11, p 2408 (2020)

Ovarian clear cell carcinoma (OCCC) is a rare subtype of gynecological cancer for which well-characterized and authenticated model systems are scarce. We provide an extensive characterization of ‘105C’, a cell line generated from an adenocarcinom

Externí odkaz: https://doaj.org/article/8c7b852cf47e41318576b9c8f4297d14

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Akademický článek

Evidence for differential viral oncolytic efficacy in an in vitro model of epithelial ovarian cancer metastasis

Autor: Jessica G Tong, Yudith Ramos Valdes, John W Barrett, John C Bell, David Stojdl, Grant McFadden, J Andrea McCart, Gabriel E DiMattia, Trevor G Shepherd

Publikováno v: Molecular Therapy: Oncolytics, Vol 2, Iss , Pp - (2015)

Epithelial ovarian cancer is unique among most carcinomas in that metastasis occurs by direct dissemination of malignant cells traversing throughout the intraperitoneal fluid. Accordingly, we test new therapeutic strategies using an in vitro three-di

Externí odkaz: https://doaj.org/article/c244a8fac6094fe2bac70100a0881479

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Akademický článek

Netrin signaling mediates survival of dormant epithelial ovarian cancer cells

Autor: Pirunthan Perampalam, James I MacDonald, Komila Zakirova, Daniel T Passos, Sumaiyah Wasif, Yudith Ramos-Valdes, Maeva Hervieu, Patrick Mehlen, Rob Rottapel, Benjamin Gibert, Rohann JM Correa, Trevor G Shepherd, Frederick A Dick

Publikováno v: eLife, Vol 12 (2024)

Dormancy in cancer is a clinical state in which residual disease remains undetectable for a prolonged duration. At a cellular level, rare cancer cells cease proliferation and survive chemotherapy and disseminate disease. We created a suspension cultu

Externí odkaz: https://doaj.org/article/fb52aec78d484fa7a44a296e56c0db33

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