Development of an MRI contrast agent for both detection and inhibition of the amyloid-b fibrillation process

Autor: Yudi Utomo, Rohmad, Okada, Satoshi, Akira, Sumiyoshi, Asawa, Yasunobu, Seung Ban, Hyun, Yoshimori, Atsushi, Aoki, Ichio, Jürgen, Bajorath, Nakamura, Hiroyuki, Ichio, Aoki

Publikováno v: RSC Advances. 12:5027-5030

A curcumin derivative conjugated with Gd-DO3A (Gd-DO3A-Comp.B) was synthesised as an MRI contrast agent for detecting the amyloid- (A) fibrillation process. Gd-DO3A-Comp.B inhibited Aß aggregation significantly and detected the fibril growth at 20 u

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=jairo_______::57ca79748c91190dcb6175b89490888b
https://repo.qst.go.jp/records/85010

Anti-proliferative and Anti-metastatic Potential of Curcumin Analogue, Pentagamavunon-1 (PGV-1), Toward Highly Metastatic Breast Cancer Cells in Correlation with ROS Generation.

Autor: Meiyanto E; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Universitas Gadjah Mada, Yogyakarta 55281 Indonesia.; Cancer Chemoprevention Research Center, Faculty of Pharmacy, Universitas Gadjah Mada, Yogyakarta 55281 Indonesia., Putri H; Cancer Chemoprevention Research Center, Faculty of Pharmacy, Universitas Gadjah Mada, Yogyakarta 55281 Indonesia., Arum Larasati Y; Cancer Chemoprevention Research Center, Faculty of Pharmacy, Universitas Gadjah Mada, Yogyakarta 55281 Indonesia., Yudi Utomo R; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Universitas Gadjah Mada, Yogyakarta 55281 Indonesia.; Cancer Chemoprevention Research Center, Faculty of Pharmacy, Universitas Gadjah Mada, Yogyakarta 55281 Indonesia., Istighfari Jenie R; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Universitas Gadjah Mada, Yogyakarta 55281 Indonesia., Ikawati M; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Universitas Gadjah Mada, Yogyakarta 55281 Indonesia., Lestari B; Cancer Chemoprevention Research Center, Faculty of Pharmacy, Universitas Gadjah Mada, Yogyakarta 55281 Indonesia.; Laboratory of Tumor Cell Biology, Nara Institute of Science and Technology, Japan., Yoneda-Kato N; Laboratory of Tumor Cell Biology, Nara Institute of Science and Technology, Japan., Nakamae I; Laboratory of Tumor Cell Biology, Nara Institute of Science and Technology, Japan., Kawaichi M; Laboratory of Gene Function in Animals, Nara Institute of Science and Technology, Japan., Kato JY; Laboratory of Tumor Cell Biology, Nara Institute of Science and Technology, Japan.

Publikováno v: Advanced pharmaceutical bulletin [Adv Pharm Bull] 2019 Aug; Vol. 9 (3), pp. 445-452. Date of Electronic Publication: 2019 Aug 01.