Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Yudan Fan"'
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 11 (2023)
Transcription elongation is a fundamental molecular process which is accurately regulated to ensure proper gene expression in cellular activities whereas its malfunction is associated with impaired cellular functions. Embryonic stem cells (ESCs) have
Externí odkaz:
https://doaj.org/article/bcdbe9dc83fe4392ab468a4863039f2c
Autor:
Rui Zhou, Wangjun Bu, Yudan Fan, Ziwei Du, Jian Zhang, Shu Zhang, Jin Sun, Zongfang Li, Jun Li
Publikováno v:
Medicina, Vol 59, Iss 2, p 321 (2023)
Background and Objectives: Most published research has only investigated a single timepoint after the onset of severe acute pancreatitis (SAP), meaning that they have been unable to observe the relationship between the dynamic changes in cytokines an
Externí odkaz:
https://doaj.org/article/6059783f9e664ea7b57288792f23faaa
Publikováno v:
British Journal of Pharmacology. 176:491-504
Background and purpose The biological significance of the multi-site phosphorylation of Bcl-2 at its loop region (T69, S70 and S87) has remained controversial for decades. This is a major obstacle for understanding apoptosis and anti-tumour drug deve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8fc9848cb4419f9daa181d9138413419
https://doi.org/10.1111/bph.14555
https://doi.org/10.1111/bph.14555
Publikováno v:
Biochemical Pharmacology. 155:102-109
Targeting Bcl-2 with ABT-199 (Venetoclax) shows limited single-agent activity against many cancers in both preclinical and clinical investigations. Combination therapies have attracted great attention. The principal purpose of this study was to inves
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54867a606f7fc0549b028253e4ba618f
https://doi.org/10.1016/j.bcp.2018.06.019
https://doi.org/10.1016/j.bcp.2018.06.019
Publikováno v:
Food and Agricultural Immunology. 28:1181-1195
Pilose antler is a rare animal-sourced traditional Chinese medicine that has been demonstrated to cause a change in total immunity. Little is known about its specific effect on immune cells. In this study, the immunological modulatory effects of pilo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::86072ee833ce9effe4289f25ebab50c6
https://doi.org/10.1080/09540105.2017.1332011
https://doi.org/10.1080/09540105.2017.1332011
Publikováno v:
2018 IEEE 4th International Conference on Computer and Communications (ICCC).
Previous network-based protocol reverse engineering methods have only considered plaintext format of payload, and have not been suitable for security protocols which include many ciphertext data. We propose a novel approach to reverse security protoc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a2bab3e14635bf8cb7ddeac083a3c881
https://doi.org/10.1109/compcomm.2018.8780606
https://doi.org/10.1109/compcomm.2018.8780606
Autor:
Wenjie Xu, Yudan Fan, Lu Liu, Zongwei Guo, Ting Song, Yingang Feng, Ziqian Wang, Anhui Wang, Zhichao Zhang
Publikováno v:
Journal of Medicinal Chemistry. 59:3152-3162
No α-helical mimetic that exhibits Bcl-2/MDM2 dual inhibition has been rationally designed due to the different helicities of the α-helixes at their binding interfaces. Herein, we extracted a one-turn α-helix-mimicking ortho-triarene unit from o-p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fae02e33deb7e0342389100984bceac
https://doi.org/10.1021/acs.jmedchem.5b01913
https://doi.org/10.1021/acs.jmedchem.5b01913
Autor:
Ziqian, Wang, Wenjie, Xu, Ting, Song, Zongwei, Guo, Lu, Liu, Yudan, Fan, Anhui, Wang, Zhichao, Zhang
Publikováno v:
Archiv der Pharmazie. 350(1)
Based on a known selective Mcl-1 inhibitor, 6-chloro-3-(3-(4-chloro-3,5-dimethylphenoxy)propyl)-1H-indole-2-carboxylic acid, we applied a fragment-based approach to obtain new molecules that extended into the p1 pocket of the BH3 groove and then exhi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ff3b46b52d46bec67777e591a02ef478
https://pubmed.ncbi.nlm.nih.gov/27911011
https://pubmed.ncbi.nlm.nih.gov/27911011
Autor:
Zhichao Zhang, Gaobo Chai, Zhiqiang Li, Xiangqian Li, Fangling Ji, Ting Song, Ziqian Wang, Yudan Fan, Yingang Feng
Publikováno v:
Angewandte Chemie (International ed. in English). 55(46)
By means of limited proteolysis assay, three-dimensional NMR, X-ray crystallography and alanine mutations, a dynamic region at the Q221R222N223 motif in the Bcl-2 homology 3 (BH3) domain of Mcl-1 has been identified as a conformational switch which c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df22090e618ba6d47fae9cf4bf7505cf
https://pubmed.ncbi.nlm.nih.gov/27701804
https://pubmed.ncbi.nlm.nih.gov/27701804
Publikováno v:
Chemical biologydrug design. 87(4)
Inhibition of interactions between Mcl-1 and proapoptotic proteins is considered to be a therapeutic strategy to induce apoptosis in cancer cells. Here, we adopted molecular dynamics simulation with molecular mechanics-Poisson Boltzmann/surface area
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec3edf41b68cacb72e258b9e34bfd231
https://pubmed.ncbi.nlm.nih.gov/26518611
https://pubmed.ncbi.nlm.nih.gov/26518611