Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Yudai Tabuchi"'
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 4, p 3525 (2023)
Monoclonal antibody therapies targeting immuno-modulatory targets such as checkpoint proteins, chemokines, and cytokines have made significant impact in several areas, including cancer, inflammatory disease, and infection. However, antibodies are com
Externí odkaz:
https://doaj.org/article/65370de06ff043bb939e6ac3765904c3
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 14, p 7778 (2022)
A major obstacle to the therapeutic application of an aptamer is its susceptibility to nuclease digestion. Here, we confirmed the acquisition of relative nuclease resistance of a DNA-type thrombin binding aptamer with a warhead (TBA3) by covalent bin
Externí odkaz:
https://doaj.org/article/b27eda1322da42748394efcc5cad9418
Publikováno v:
International Journal of Molecular Sciences, Vol 19, Iss 11, p 3682 (2018)
To determine the binding-site of a combinatorially-selected peptide possessing a fluoroprobe, a novel cysteine reactive small photo-crosslinker that can be excited by a conventional long-wavelength ultraviolet handlamp (365 nm) was synthesized via Su
Externí odkaz:
https://doaj.org/article/06504aca3fd14ca79db5fad3d429190d
Autor:
Riku, Katsuki, Tsubasa, Numayama, Yudai, Tabuchi, Jaiyam, Sharma, Naohito, Satake, Adarsh, Sandhu, Masumi, Taki
Publikováno v:
Analytical and Bioanalytical Chemistry. 414:4803-4807
We have previously established a selection system to obtain a solvatochromic protein binder from a peptidic fluoroprobe library via the extended T7 phage display. Here, we use the peptidic binder as a fluororeporter in this proof-of-concept study of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a0be8257453c9b6cab51df35eeb207f
https://doi.org/10.1007/s00216-022-04128-x
https://doi.org/10.1007/s00216-022-04128-x
Publikováno v:
Chemical Communications. 57(20):2483-2486
Alleviating the potential risk of irreversible adverse drug effects has been an important and challenging issue for the development of covalent drugs. Here we created a DNA-aptamer-type covalent drug by introducing a sulfonyl fluoride warhead at appr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::084ae0e17522aa6975f0145f13a678cc
http://id.nii.ac.jp/1438/00009979/
http://id.nii.ac.jp/1438/00009979/
Publikováno v:
Chemical communications (Cambridge, England). 57(44)
A peptide-type covalent binder for a target protein was obtained by direct and stringent screening of a warhead-modified peptide library on the robust T7 phage. The aryl fluorosulfate (fosylate) warhead was activated only in a matchmaking microenviro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a33309f854c1106c187ba3ff7656bfea
https://pubmed.ncbi.nlm.nih.gov/33978001
https://pubmed.ncbi.nlm.nih.gov/33978001
Fluorescent 'keep-on' type pharmacophore obtained from dynamic combinatorial library of Schiff bases
Autor:
Yudai Tabuchi, Masumi Taki
Publikováno v:
Analytical and Bioanalytical Chemistry. 410:6713-6717
We established a novel principle for fluorescence detection of a target protein. A low-molecular-weight fluorescent pharmacophore, as a targeted probe, was selected from a dynamic combinatorial library of Schiff bases. The pharmacophore retains its f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cea3ca3bfbfe24762bc64355afbfcb8c
https://doi.org/10.1007/s00216-018-1303-4
https://doi.org/10.1007/s00216-018-1303-4
Publikováno v:
Bioconjugate Chemistry. 29:1866-1871
A peptide-type covalent binder for a target protein was obtained by combinatorial screening of fluoroprobe-conjugated peptide libraries on bacteriophage T7. The solvatochromic fluoroprobe works as a bait during the affinity selection process of phage
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84afa1fcdf596be2285be440a1345389
https://doi.org/10.1021/acs.bioconjchem.8b00301
https://doi.org/10.1021/acs.bioconjchem.8b00301
Publikováno v:
International Journal of Molecular Sciences, Vol 19, Iss 11, p 3682 (2018)
International Journal of Molecular Sciences
International Journal of Molecular Sciences
To determine the binding-site of a combinatorially-selected peptide possessing a fluoroprobe, a novel cysteine reactive small photo-crosslinker that can be excited by a conventional long-wavelength ultraviolet handlamp (365 nm) was synthesized via Su
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1dc96933ee47d644f089b1954cd1b4a
https://www.mdpi.com/1422-0067/19/11/3682
https://www.mdpi.com/1422-0067/19/11/3682
Publikováno v:
Proceedings of the 35th European Peptide Symposium.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fc1eec816c7b73e5d97f8a9674b2e107
https://doi.org/10.17952/35eps.2018.272
https://doi.org/10.17952/35eps.2018.272