Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Yuda Huo"'
Publikováno v:
Acta Neuropathologica Communications, Vol 11, Iss 1, Pp 1-9 (2023)
Abstract Rare cases of paraneoplastic obesity in children suggest sporadic obesity might also arise from an adaptive immune cell-mediated mechanism. Since the hypothalamus is a central regulator of feeding behavior and energy expenditure, we quantifi
Externí odkaz:
https://doaj.org/article/433cb105efde479aa96d762e322439b9
Autor:
Monica J. S. Nadler, Weipang Chang, Ekim Ozkaynak, Yuda Huo, Yi Nong, Morgane Boillot, Mark Johnson, Antonio Moreno, Matthew P. Anderson
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-17 (2023)
Human-specific SINE-VNTR-Alu (SVA) retrotransposons in neurodevelopmental genes CDK5RAP2 and SCN8A repress their expression to delay neuronal maturation. SVA-lncRNA AK057321 binds these SVAs to release gene repression and drive neuronal maturation.
Externí odkaz:
https://doaj.org/article/aca25956f52c469ba5776582c1a9a221
Publikováno v:
iScience, Vol 25, Iss 7, Pp 104573- (2022)
Summary: Autism spectrum disorder (ASD) is a neurodevelopmental disorder with high genetic heterogeneity, affecting one in 44 children in the United States. Recent genomic sequencing studies from autistic human individuals indicate that PARK2, a gene
Externí odkaz:
https://doaj.org/article/768d4f9259784d0d8bb722261d336c44
Publikováno v:
iScience, Vol 25, Iss 7, Pp 104595- (2022)
Summary: Duplication and haploinsufficiency of the USP7 gene are implicated in autism spectrum disorders (ASD), but the role for USP7 in neurodevelopment and contribution to ASD pathogenesis remain unknown. We find that in primary neurons, overexpres
Externí odkaz:
https://doaj.org/article/433c3bf1473a43b5a796f8498f3ba6e8
Autor:
Yang-Ping Shentu, Yuda Huo, Xiao-Long Feng, James Gilbert, Qing Zhang, Zhen-Yu Liuyang, Xiu-Lian Wang, Guan Wang, Huan Zhou, Xiao-Chuan Wang, Jian-Zhi Wang, You-Ming Lu, Jukka Westermarck, Heng-Ye Man, Rong Liu
Publikováno v:
Cell Reports, Vol 24, Iss 3, Pp 713-723 (2018)
Summary: Protein phosphatase 2A (PP2A) inhibition causes hyperphosphorylation of tau and APP in Alzheimer’s disease (AD). However, the mechanisms underlying the downregulation of PP2A activity in AD brain remain unclear. We demonstrate that Cancero
Externí odkaz:
https://doaj.org/article/2bfd893bc0f6445e99a6f354331a62ff
Autor:
Yi Nong, David C. Stoppel, Mark A. Johnson, Morgane Boillot, Jelena Todorovic, Jason Shen, Xinyu Zhou, Monica J.S. Nadler, Carrie Rodriguez, Yuda Huo, Ikue Nagakura, Ekkehard M. Kasper, Matthew P. Anderson
The circuit origins of aggression in autism spectrum disorder remain undefined. Here we reportTac1-expressing glutamatergic neurons in ventrolateral division of ventromedial hypothalamus (VMHvl) drive intermale aggression. Aggression is increased due
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::84ec27f9fcad416baf49fe38a5e3b53d
https://doi.org/10.1101/2023.02.28.530462
https://doi.org/10.1101/2023.02.28.530462
Publikováno v:
Neurodevelopmental Pediatrics ISBN: 9783031207914
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1f9737b3aef95bdff9f963c94506af28
https://doi.org/10.1007/978-3-031-20792-1_5
https://doi.org/10.1007/978-3-031-20792-1_5
Autor:
Wen‐Ting Hu, Zhen‐Yu Liuyang, Yuan Tian, Jia‐Wei Liang, Xiao‐Lin Zhang, Hui‐Liang Zhang, Guan Wang, Yuda Huo, Yang‐Ping Shentu, Jian‐Zhi Wang, Xiao‐Chuan Wang, You‐ming Lu, Jukka Westermarck, Heng‐Ye Man, Rong Liu
Publikováno v:
EMBO reports. 23
Major depressive disorder (MDD) is a severe mental illness. Decreased brain plasticity and dendritic fields have been consistently found in MDD patients and animal models; however, the underlying molecular mechanisms remain to be clarified. Here, we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16f9ef8de6cf39f8e48f81cba1c14775
https://doi.org/10.15252/embr.202254911
https://doi.org/10.15252/embr.202254911
Publikováno v:
iScience. 25(7)
Duplication and haploinsufficiency of the USP7 gene are implicated in autism spectrum disorders (ASD), but the role for USP7 in neurodevelopment and contribution to ASD pathogenesis remain unknown. We find that in primary neurons, overexpression of U
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8ddcb14a8582914805f7b724cf8a4b3
https://pubmed.ncbi.nlm.nih.gov/35800757
https://pubmed.ncbi.nlm.nih.gov/35800757
Publikováno v:
J Micromech Microeng
Among approaches aiming toward functional nervous system restoration, those implementing microfabrication techniques allow the manufacture of platforms with distinct geometry where neurons can develop and be guided to form patterned connections in vi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57a51b0eacde6270e437d912d2fb83f0
https://doi.org/10.1088/1361-6439/ac73d7
https://doi.org/10.1088/1361-6439/ac73d7