Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Yuchi Honaker"'
Autor:
Swati Singh, Cole M. Pugliano, Yuchi Honaker, Aidan Laird, M. Quinn DeGottardi, Ezra Lopez, Stefan Lachkar, Claire Stoffers, Karen Sommer, Iram F. Khan, David J. Rawlings
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 32, Iss 1, Pp 101183- (2024)
Immune dysregulation, polyendocrinopathy, enteropathy, X-linked (IPEX) syndrome is a monogenic disorder caused by mutations in the FOXP3 gene, required for generation of regulatory T (Treg) cells. Loss of Treg cells leads to immune dysregulation char
Externí odkaz:
https://doaj.org/article/70f1555ee4fe46088c5297fc8c0bb2a2
Autor:
Malika Hale, Baeckseung Lee, Yuchi Honaker, Wai-Hang Leung, Alexandra E. Grier, Holly M. Jacobs, Karen Sommer, Jaya Sahni, Shaun W. Jackson, Andrew M. Scharenberg, Alexander Astrakhan, David J. Rawlings
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 4, Iss C, Pp 192-203 (2017)
Gene editing by homology-directed recombination (HDR) can be used to couple delivery of a therapeutic gene cassette with targeted genomic modifications to generate engineered human T cells with clinically useful profiles. Here, we explore the functio
Externí odkaz:
https://doaj.org/article/5c8a965f6c324b0c809e18b4b234bc06
Autor:
Soo Jung Yang, Akhilesh K. Singh, Travis Drow, Tori Tappen, Yuchi Honaker, Fariba Barahmand-pour-Whitman, Peter S. Linsley, Karen Cerosaletti, Kelsey Mauk, Yufei Xiang, Jessica Smith, Emma Mortensen, Peter J. Cook, Karen Sommer, Iram Khan, Denny Liggitt, David J. Rawlings, Jane H. Buckner
Publikováno v:
Science Translational Medicine. 14
Adoptive transfer of regulatory T cells (T regs ) is therapeutic in type 1 diabetes (T1D) mouse models. T regs that are specific for pancreatic islets are more potent than polyclonal T regs in preventing disease. However, the frequency of antigen-spe
Autor:
Soo Jung Yang, Akhilesh K Singh, Tori Tappen, Yuchi Honaker, Kelsey Mauk, Jessica Smith, Karen Sommer, David Rawlings, Jane H Buckner
Publikováno v:
The Journal of Immunology. 206:18.13-18.13
Adoptive transfer of regulatory T cells (Tregs) is therapeutic in T1D mouse models. Notably, Tregs specific for pancreatic islets were shown more potent than polyclonal Tregs in blocking disease. However, the frequency of antigen-specific Tregs is ex
Autor:
Yuchi, Honaker, Nicholas, Hubbard, Yufei, Xiang, Logan, Fisher, David, Hagin, Karen, Sommer, Yumei, Song, Soo Jung, Yang, Christina, Lopez, Tori, Tappen, Elizabeth M, Dam, Iram, Khan, Malika, Hale, Jane H, Buckner, Andrew M, Scharenberg, Troy R, Torgerson, David J, Rawlings
Publikováno v:
Science translational medicine. 12(546)
Thymic regulatory T cells (tT
Autor:
Soo Jung Yang, Akhilesh Singh, Peter Cook, Yuchi Honaker, Tori Tappen, Kelsey Mauk, Jessica Smith, Karen Sommer, David J Rawlings, Jane H Buckner
Publikováno v:
The Journal of Immunology. 204:237.30-237.30
Adoptive transfer of regulatory T cells (Treg) is therapeutic in T1D mouse models. Notably, Treg specific for pancreatic islets are more potent than polyclonal Treg in blocking disease. However, the frequency of antigen-specific Treg is extremely low
Autor:
Yuchi Honaker, Zhongsheng You, Won Kyun Koh, Shan Li, Melanie A. Sparks, Helen Piwnica-Worms, Tom Ellenberger, Sharad C. Paudyal, In-Kwon Kim, Xiaoqing Chen
Publikováno v:
Journal of Biological Chemistry. 290:12300-12312
The DNA end resection process dictates the cellular response to DNA double strand break damage and is essential for genome maintenance. Although insufficient DNA resection hinders homology-directed repair and ATR (ataxia telangiectasia and Rad3 relat
Cell–cell adhesion protein αE-catenin inhibits skin squamous cell carcinoma (SCC) development; however, the mechanisms responsible for this function are not completely understood. We report here that αE-catenin inhibits β4 integrin-mediated acti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4b9739c3dbd14c97415b6de3774032f
https://europepmc.org/articles/PMC4826396/
https://europepmc.org/articles/PMC4826396/
Autor:
Ettore Appella, Yongkun Wei, Tiebang Kang, Mien Chie Hung, Yuchi Honaker, Helen Piwnica-Worms, Hiroshi Yamaguchi
Publikováno v:
Cancer Cell. 13(1):36-47
The Cdc25A phosphatase positively regulates cell-cycle transitions, is degraded by the proteosome throughout interphase and in response to stress, and is overproduced in human cancers. The kinases targeting Cdc25A for proteolysis during early cell-cy
Autor:
Sheila A. Stewart, Mai Nguyen, Helen Piwnica-Worms, Yuchi Honaker, Elise Alspach, Daniel C. Teasley, Shankar Parajuli, Abhishek Saharia, Ying Jie Lock, Hayley R. Moore
Publikováno v:
The Journal of biological chemistry. 290(24)
The existence of redundant replication and repair systems that ensure genome stability underscores the importance of faithful DNA replication. Nowhere is this complexity more evident than in challenging DNA templates, including highly repetitive or t