Zobrazeno 1 - 10
of 87
pro vyhledávání: '"Yucheng Xiao"'
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 17 (2024)
IntroductionResurgent current (INaR) generated by voltage-gated sodium channels (VGSCs) plays an essential role in maintaining high-frequency firing of many neurons and contributes to disease pathophysiology such as epilepsy and painful disorders. Ta
Externí odkaz:
https://doaj.org/article/2c80377f9ae84466b6ea9bc4ae910d16
Autor:
Kiran George, Diego Lopez-Mateos, Tarek Mohamed Abd El-Aziz, Yucheng Xiao, Jake Kline, Hong Bao, Syed Raza, James D. Stockand, Theodore R. Cummins, Luca Fornelli, Matthew P. Rowe, Vladimir Yarov-Yarovoy, Ashlee H. Rowe
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Voltage-gated sodium channel NaV1.8 regulates transmission of pain signals to the brain. While NaV1.8 has the potential to serve as a drug target, the molecular mechanisms that shape NaV1.8 gating are not completely understood, particularly mechanism
Externí odkaz:
https://doaj.org/article/0dc9b79a83a742afa9602e8aab884a62
Publikováno v:
eLife, Vol 11 (2022)
Resurgent currents (INaR) produced by voltage-gated sodium channels are required for many neurons to maintain high-frequency firing and contribute to neuronal hyperexcitability and disease pathophysiology. Here, we show, for the first time, that INaR
Externí odkaz:
https://doaj.org/article/9523fdcf8a444e838dc5323b8a3e17e1
Autor:
Tarek Mohamed Abd El-Aziz, Yucheng Xiao, Jake Kline, Harold Gridley, Alyse Heaston, Klaus D. Linse, Micaiah J. Ward, Darin R. Rokyta, James D. Stockand, Theodore R. Cummins, Luca Fornelli, Ashlee H. Rowe
Publikováno v:
Toxins, Vol 13, Iss 7, p 501 (2021)
The voltage-gated sodium channel Nav1.8 is linked to neuropathic and inflammatory pain, highlighting the potential to serve as a drug target. However, the biophysical mechanisms that regulate Nav1.8 activation and inactivation gating are not complete
Externí odkaz:
https://doaj.org/article/66078cee5d4c41428eff491c6e30d661
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
Cardiac voltage-gated sodium channels (Nav1.5) are crucial regulators of heart electric activity. Here the authors show that palmitoylation, a process of lipid modification of cysteine residues, modulates Nav1.5 function and affects cardiomyocyte exc
Externí odkaz:
https://doaj.org/article/ab603083dedd44c1938573e6d1f39389
Publikováno v:
Sensors, Vol 20, Iss 18, p 5040 (2020)
Detection technology of underwater pipeline leakage plays an important role in the subsea production system. In this paper, a new method based on the acoustic leak signal collected by a hydrophone is proposed to detect pipeline leakage in the subsea
Externí odkaz:
https://doaj.org/article/7161265625f441868476a6106d933fc7
Autor:
Kayla Thompson, Jonathan Chen, Qianyi Luo, Yucheng Xiao, Theodore R Cummins, Ashay D Bhatwadekar
Publikováno v:
PLoS ONE, Vol 13, Iss 2, p e0193280 (2018)
Diabetic retinopathy (DR) is a major cause of adult blindness. Retinal Müller cells maintain water homeostasis and potassium concentration via inwardly rectifying Kir4.1 channels. Accumulation of advanced glycation end products (AGEs) is a major pat
Externí odkaz:
https://doaj.org/article/503ef3f8207e4bfe81d86e714c7022fa
Publikováno v:
PLoS ONE, Vol 10, Iss 7, p e0133485 (2015)
Voltage-gated sodium channels are responsible for the initiation and propagation of action potentials (APs). Two brain isoforms, Nav1.1 and Nav1.6, have very distinct cellular and subcellular expression. Specifically, Nav1.1 is predominantly expresse
Externí odkaz:
https://doaj.org/article/fac42460566a4987b4b1c40bb8bc95a5
Autor:
Ashlee H Rowe, Yucheng Xiao, Joseph Scales, Klaus D Linse, Matthew P Rowe, Theodore R Cummins, Harold H Zakon
Publikováno v:
PLoS ONE, Vol 6, Iss 8, p e23520 (2011)
Among scorpion species, the Buthidae produce the most deadly and painful venoms. However, little is known regarding the venom components that cause pain and their mechanism of action. Using a paw-licking assay (Mus musculus), this study compared the
Externí odkaz:
https://doaj.org/article/9066800615b64898964626403cddf4d9
Autor:
Yacine Touahri, Luke Ajay David, Joseph Hanna, Satoshi Okawa, Hedy Liu, Yucheng Xiao, Alissa Pak, Yaroslav Ilnytskyy, Edwin van Oosten, Nobuhiko tachibana, Lata Adnani, Jiayi Zhao, Mary Hoffman, Rajiv Dixit, Dawn Zinyk, Cynthia J. Guidos, Volker Enzmann, Pengpeng Bi, Isabelle Aubert, Laurent Journot, Igor Kovalchuk, Yves Sauvé, Jeff Biernaskie, Chao Wang, Antonio del Sol, Carol Janine Schuurmans
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::71d25af604eeefe9fc3b34d7ffa7aa67
https://doi.org/10.2139/ssrn.4423987
https://doi.org/10.2139/ssrn.4423987