Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Yuchen Chien"'
Publikováno v:
Applied Sciences, Vol 14, Iss 18, p 8128 (2024)
The primary objective of this study is to investigate the carbon footprint, resilience levels, and optimal landscape area ratios of various parks. Additionally, it explores the relationships between landscape element proportions (LEP), the normalized
Externí odkaz:
https://doaj.org/article/516c5da70b484eec9838a6182ff07886
Autor:
Vissia Viglietta, Fonda Liu, Marie-Laure Rouzade-Dominguez, Marie-Emmanuelle Riviere, Yihan Sui, Udo Eichenlaub, Eric M. Reiman, Yuchen Chien, Ulf Neumann, Beth Borowsky, Matt Quinn, Nicholas Seneca, Ana Graf, Pilar Cazorla, Angelika Caputo
Publikováno v:
Alzheimer's & Dementia. 16
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::02208c30f5767572fdf686900de1e5f2
https://doi.org/10.1002/alz.041143
https://doi.org/10.1002/alz.041143
Autor:
Scott C. Kogan, Xiaowo Wang, Weijun Luo, Cheng S. Lee, Jessica E. Bolden, Xueping Fang, Claudio Scuoppo, Prem K. Premsrirut, Scott W. Lowe, Agustin Chicas, Yuchen Chien, Brian M. Balgley
Publikováno v:
Genes & Development. 25:2125-2136
Cellular senescence acts as a potent barrier to tumorigenesis and contributes to the anti-tumor activity of certain chemotherapeutic agents. Senescent cells undergo a stable cell cycle arrest controlled by RB and p53 and, in addition, display a senes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::910ca7e92f5542dbe316aa3e12f91ff3
https://doi.org/10.1101/gad.17276711
https://doi.org/10.1101/gad.17276711
Autor:
Yueh Ming Loo, Ron Bumeister, Yingming Zhao, Michael A. White, Levy Kopelovich, Michael Gale, Jacques Camonis, Yuchen Chien, Cynthia L. Johnson, Mirey G. Balakireva, Charles Yeaman, Yves Romeo, Sung Won Kwon, Sung Chan Kim
Publikováno v:
Cell. 127:157-170
SummaryThe monomeric RalGTPases, RalA and RalB are recognized as components of a regulatory framework supporting tumorigenic transformation. Specifically, RalB is required to suppress apoptotic checkpoint activation, the mechanistic basis of which is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::133fea304b645d42037728e630fdf9c2
https://doi.org/10.1016/j.cell.2006.08.034
https://doi.org/10.1016/j.cell.2006.08.034
Autor:
Michael A. White, Yuchen Chien
Publikováno v:
EMBO reports. 4:800-806
The monomeric RAL (RAS-like) GTPases have been indirectly implicated in mitogenic regulation and cell transformation. Here, we show that RALA and RALB collaborate to maintain tumorigenicity through regulation of both proliferation and survival. Remar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85a69a24f0ed8e0ce758df9af76b0755
https://doi.org/10.1038/sj.embor.embor899
https://doi.org/10.1038/sj.embor.embor899
Autor:
Yuchen Chien, Scott W. Lowe
Publikováno v:
Cell. 132(3):339-341
Expression of an oncogene in a primary cell can, paradoxically, block proliferation by inducing senescence or apoptosis through pathways that remain to be elucidated. Here we perform genome-wide RNA-interference screening to identify 17 genes require
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b602be6e9161ca90854302008b37dfb6
Autor:
Yuchen, Chien, Michael A, White
Publikováno v:
Methods in enzymology. 438
The Ras-like GTPases, RalA and RalB, are key components of the oncogenic Ras signaling network. Recent evidence suggests that RalA and RalB collaborate to support tumorigenic transformation through distinct cell regulatory events. While RalA is appar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::44fac25881001f656e226d9bb5894bb5
https://pubmed.ncbi.nlm.nih.gov/18413258
https://pubmed.ncbi.nlm.nih.gov/18413258
Autor:
Michael A. White, Yuchen Chien
The Ras-like GTPases, RalA and RalB, are key components of the oncogenic Ras signaling network. Recent evidence suggests that RalA and RalB collaborate to support tumorigenic transformation through distinct cell regulatory events. While RalA is appar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::19c58b04556f4d65484c1f766e6c8668
https://doi.org/10.1016/s0076-6879(07)38022-1
https://doi.org/10.1016/s0076-6879(07)38022-1
Autor:
Yuchen Chien
We have previously identified the Ras-like GTpases, RalA and RalB as linchpin modulators of human tumor cell proliferation and survival. Using RNAi-mediated loss-of-function analysis, we find that RalA is critical for anchorage-independent growth whe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bbcab0178e6e9718ac8cf75649e4bb46
https://doi.org/10.21236/ada435549
https://doi.org/10.21236/ada435549
Publikováno v:
Cancer Research. 74:5505-5505
MDM2, the most prominent natural inhibitor of the p53 tumor suppressor pathway, and BCL2, an anti-apoptotic regulator and important player in preventing induction of apoptosis in tumor cells, both play a pivotal role in leukemia cell survival and res
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9ae70b73886db4a55f0e4e43ed00e3a3
https://doi.org/10.1158/1538-7445.am2014-5505
https://doi.org/10.1158/1538-7445.am2014-5505