SMND-309, a novel derivative of salvianolic acid B, protects rat brains ischemia and reperfusion injury by targeting the JAK2/STAT3 pathway

Autor: Jingwei Tian, Yubai Gao, Li-bo Zou, Haibo Zhu, Guangying Du

Publikováno v: European Journal of Pharmacology. 714:23-31

SMND-309 is a novel derivative of salvianolic acid B, and has shown protective effects against rat cortical neuron damage in vitro and in vivo. However the molecular mechanisms through which SMND-309 affords this protection are unclear. The present s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac26c28a871d43031834b0c1a3f1ee64
https://doi.org/10.1016/j.ejphar.2013.05.043

Protections of SMND-309, a novel derivate of salvianolic acid B, on brain mitochondria contribute to injury amelioration in cerebral ischemia rats

Autor: Yunjuan Zhang, Fenghua Fu, Guisheng Li, Yubai Gao, Changlu Li, Jingwei Tian, Fu Liu, Qingsheng Meng

Publikováno v: Phytomedicine. 16:726-733

SMND-309, a novel compound named (2E)-2-{6-[(E)-2-carboxylvinyl]-2,3-dihydroxyphenyl}-3-(3,4-dihydroxyphenyl) propenoic acid, is a new derivate of salvianolic acid B. The present study was conducted to investigate whether SMND-309 has a protective ef

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b14f36007ddc278573ddc4ecbe9e78ae
https://doi.org/10.1016/j.phymed.2009.01.007

Paeoniflorin inhibits systemic inflammation and improves survival in experimental sepsis

Autor: Hai-Bo Zhu, Xiguang Chen, Yubai Gao, Jingwei Tian, Wang-Lin Jiang, Fenghua Fu

Publikováno v: Basicclinical pharmacologytoxicology. 105(1)

The present study was carried out to investigate the effects of paeoniflorin in cultured RAW264.7 cell line as well as in an experimental model of sepsis induced by cecal ligation and puncture, and intraperitoneal injection (i.p.) of lipopolysacchari

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc25cf66bb9abf153d7bded04350fce6
https://pubmed.ncbi.nlm.nih.gov/19371254

SMND-309, a Novel Derivate of Salvianolic Acid B, Attenuates Apoptosis and Ameliorates Mitochondrial Energy Metabolism in Rat Cortical Neurons.

Autor: Jingwei Tian, Guisheng Li, Shumin Zhang, Yubai Gao, Wanglin Jiang, Fenghua Fu, Zhifeng Liu

Publikováno v: Basic & Clinical Pharmacology & Toxicology; Feb2009, Vol. 104 Issue 2, p176-184, 9p, 1 Black and White Photograph, 1 Diagram, 5 Charts, 2 Graphs