Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Yuanzhong Pan"'
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
E-boxes are important regulatory elements in the eukaryotic genome. Transcription factors can bind to E-boxes through their basic helix-loop-helix or zinc finger domain to regulate gene transcription. E-box-binding transcription factors (EBTFs) are i
Externí odkaz:
https://doaj.org/article/ac565b28eb8044688895bc454e349f93
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America; 2/13/2024, Vol. 121 Issue 7, p1-8, 18p
Publikováno v:
Cancer Research. 83:P6-10
Pharmacological Strategies to Target Circadian Clock Genes in TNBC Yuanzhong Pan, Priya Jayachandran, Evanthia T. Roussos Torres, Steve A. Kay Background: Triple-negative breast cancer (TNBC) remains the most aggressive form of breast cancer and more
Autor:
Priya Jayachandran, Yasmine Baca, Joanne Xiu, Yuanzhong Pan, Phil Walker, Francesca Battaglin, Hiroyuki Arai, Moh’d Khushman, Janice Lu, Darcy Spicer, Shannon Mumenthaler, Richard Goldberg, Benjamin Weinberg, Emil Lou, Michael Hall, Arielle L. Heeke, W. Michael Korn, Steve A. Kay, Heinz-Josef Lenz, Evanthia T. Roussos Torres
Publikováno v:
Cancer Research. 83:P4-08
Background: Disruption of circadian processes has been linked to cancer initiation, progression, metastasis, resistance, and mortality. Clock proteins are an emerging target for therapy in breast cancer. Circadian rhythms are controlled by a network
Autor:
Kai Dai, Qinghao Zhang, Shunshu Deng, Yuanman Yu, Fuwei Zhu, Shuang Zhang, YuanZhong Pan, Dandan Long, Jing Wang, Changsheng Liu
Publikováno v:
Science advances. 9(1)
Cell therapies and regenerative medicine interventions require an adequate source of therapeutic cells. Here, we demonstrate that constructing in vivo osteo-organoids by implanting bone morphogenetic protein–2–loaded scaffolds into the internal m
Autor:
Meng Qu, Francesca Battaglin, Evanthia T. Roussos Torres, Erin Spiller, Shivani Soni, Yuanzhong Pan, Heinz-Josef Lenz, Sofi Castanon, Priscilla Chan, Shannon M. Mumenthaler, Steve A. Kay
Publikováno v:
Oncogene
Disruption of the cellular pathway modulating endogenous 24-hour rhythms, referred to as ‘the circadian clock’, has been recently proven to be associated with cancer risk, development and progression. This pathway operates through a complex netwo
Publikováno v:
Cancer Research. 83:3715-3715
Transcription factors (TFs) are key regulators of homeostasis and cancer. Recent advances in pharmacological targeting of TFs makes them valuable targets in various diseases, but systems-level understanding of the function and regulation of TFs from
Harnessing matrix stiffness to engineer a bone marrow niche for hematopoietic stem cell rejuvenation
Autor:
Xiaoying Zhang, Dandan Cao, Liting Xu, Yanhua Xu, Zehua Gao, Yuanzhong Pan, Ming Jiang, Yuhui Wei, Lihua Wang, Yue Liao, Qigang Wang, Lei Yang, Xiaocui Xu, Yawei Gao, Shaorong Gao, Jing Wang, Rui Yue
Publikováno v:
Cell Stem Cell. 30:378-395.e8
Publikováno v:
Carbohydrate polymers. 281
Bone regeneration and vascularization have presented a clinical challenge for decades. Considering the importance of stem cells, such as mesenchymal stem cells (MSCs), in bone regeneration, endothelial progenitor cells (EPCs) are crucial during bone
Publikováno v:
Acta Biomaterialia
Bone morphogenetic protein-2 (BMP-2) involved therapy is of great potential for bone regeneration. However, its clinical application is restricted due to the undesirable bioactivity and relevant complications in vivo. Immobilization of recombinant BM