Zobrazeno 1 - 10
of 43
pro vyhledávání: '"Yuanzheng Gu"'
Autor:
Dilara O. Halim, Gopinath Krishnan, Evan P. Hass, Soojin Lee, Mamta Verma, Sandra Almeida, Yuanzheng Gu, Deborah Y. Kwon, Thomas G. Fazzio, Fen-Biao Gao
Publikováno v:
Cell Reports, Vol 43, Iss 7, Pp 114375- (2024)
Summary: GGGGCC (G4C2) repeat expansion in C9ORF72 is the most common genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). How this genetic mutation leads to neurodegeneration remains largely unknown. Using CRISPR-C
Externí odkaz:
https://doaj.org/article/db2eea12f92c422ea5615950ffbf79b1
Autor:
Yuanzheng Gu, Xianglin Chen, Yan Shen, Xiaoyong Chen, Gongxiu He, Xinxing He, Guangjun Wang, Hanjie He, Zhencheng Lv
Publikováno v:
Frontiers in Microbiology, Vol 14 (2023)
Nitrogen (N) as an essential macronutrient affects the soil nutrient cycle, microbial community abundance, and metabolic function. However, the specific responses of microorganisms and metabolic functions in rhizosphere soil of Phellodendron chinense
Externí odkaz:
https://doaj.org/article/96c5c5ddcb8547e1b826c097f9d9083c
Autor:
Yoshifumi Sonobe, Soojin Lee, Gopinath Krishnan, Yuanzheng Gu, Deborah Y Kwon, Fen-Biao Gao, Raymond P Roos, Paschalis Kratsios
Publikováno v:
eLife, Vol 12 (2023)
A hexanucleotide repeat expansion in C9ORF72 is the most common genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). A hallmark of ALS/FTD pathology is the presence of dipeptide repeat (DPR) proteins, produced from
Externí odkaz:
https://doaj.org/article/6bc688523ce84ba29c9ad618fffb3838
Autor:
Yoshifumi Sonobe, Jihad Aburas, Gopinath Krishnan, Andrew C. Fleming, Ghanashyam Ghadge, Priota Islam, Eleanor C. Warren, Yuanzheng Gu, Mark W. Kankel, André E. X. Brown, Evangelos Kiskinis, Tania F. Gendron, Fen-Biao Gao, Raymond P. Roos, Paschalis Kratsios
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
A hexanucleotide repeat expansion of C9orf72 is translated to dipeptide repeat proteins in amyotrophic lateral sclerosis and frontotemporal dementia patients. Here the authors generate a C. elegans model of C9orf72-mediated ALS/FTD and show that tran
Externí odkaz:
https://doaj.org/article/05cc015c8b3f412d9f643d4bb372f4aa
Publikováno v:
iScience, Vol 9, Iss , Pp 120-137 (2018)
Summary: Fast-spiking (FS) neurons can fire action potentials (APs) up to 1,000 Hz and play key roles in vital functions such as sound location, motor coordination, and cognition. Here we report that the concerted actions of Kv3 voltage-gated K+ (Kv)
Externí odkaz:
https://doaj.org/article/5f3a097e30a4409a9e283756be625547
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 10 (2017)
The development of neuroprotective and repair strategies for treating progressive multiple sclerosis (MS) requires new insights into axonal injury. 4-aminopyridine (4-AP), a blocker of voltage-gated K+ (Kv) channels, is used in symptomatic treatment
Externí odkaz:
https://doaj.org/article/b09ef1de479145ac9b07725f173ee29e
Autor:
Yuanzheng Gu, Chen Gu
Publikováno v:
PLoS ONE, Vol 5, Iss 8, p e11931 (2010)
Concerted actions of various ion channels that are precisely targeted along axons are crucial for action potential initiation and propagation, and neurotransmitter release. However, the dynamics of channel protein transport in axons remain unknown. H
Externí odkaz:
https://doaj.org/article/5d71a85a0db14298b1bcf852b9dda953
Autor:
Sonobe, Yoshifumi, Lee, Soojin, Krishnan, Gopinath, Yuanzheng Gu, Kwon, Deborah Y., Fen-Biao Gao, Roos, Raymond P., Kratsios, Paschalis
Publikováno v:
eLife; 9/29/2023, p1-25, 25p
Autor:
Melanie, Jambeau, Kevin D, Meyer, Marian, Hruska-Plochan, Ricardos, Tabet, Chao-Zong, Lee, Ananya, Ray-Soni, Corey, Aguilar, Kitty, Savage, Nibha, Mishra, Nicole, Cavegn, Petra, Borter, Chun-Chia, Lin, Karen R, Jansen-West, Jie, Jiang, Fernande, Freyermuth, Nan, Li, Pierre, De Rossi, Manuela, Pérez-Berlanga, Xin, Jiang, Lilian M, Daughrity, João, Pereira, Sarav, Narayanan, Yuanzheng, Gu, Shekhar, Dhokai, Isin, Dalkilic-Liddle, Zuzanna, Maniecka, Julien, Weber, Michael, Workman, Melissa, McAlonis-Downes, Eugene, Berezovski, Yong-Jie, Zhang, James, Berry, Brian J, Wainger, Mark W, Kankel, Mia, Rushe, Christoph, Hock, Roger M, Nitsch, Don W, Cleveland, Leonard, Petrucelli, Tania F, Gendron, Fabio, Montrasio, Jan, Grimm, Magdalini, Polymenidou, Clotilde, Lagier-Tourenne
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 119(49)
Hexanucleotide G
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0d6c3782c6f07b9052738b525636b5ee
https://pubmed.ncbi.nlm.nih.gov/36454749
https://pubmed.ncbi.nlm.nih.gov/36454749
Autor:
Fen-Biao Gao, Evangelos Kiskinis, Jihad Aburas, Mark W. Kankel, Yuanzheng Gu, Tania F. Gendron, Yoshifumi Sonobe, Priota Islam, André Ex Brown, Raymond P. Roos, Paschalis Kratsios, Andrew C. Fleming, Gopinath Krishnan, Eleanor C. Warren, Ghanashyam D. Ghadge
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
A hexanucleotide repeat expansion GGGGCC in the non-coding region of C9orf72 is the most common cause of inherited amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Toxic dipeptide repeats (DPRs) are synthesized from GGGGCC via r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd786bbdd341465cc73e0de3c49fe3cc
https://doaj.org/article/05cc015c8b3f412d9f643d4bb372f4aa
https://doaj.org/article/05cc015c8b3f412d9f643d4bb372f4aa