Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Yuanxiu Chen"'
Autor:
Adebowale Adeyemo, Norman Gerry, Guanjie Chen, Alan Herbert, Ayo Doumatey, Hanxia Huang, Jie Zhou, Kerrie Lashley, Yuanxiu Chen, Michael Christman, Charles Rotimi
Publikováno v:
PLoS Genetics, Vol 5, Iss 7, p e1000564 (2009)
The evidence for the existence of genetic susceptibility variants for the common form of hypertension ("essential hypertension") remains weak and inconsistent. We sought genetic variants underlying blood pressure (BP) by conducting a genome-wide asso
Externí odkaz:
https://doaj.org/article/20a7da60efcc42948501239fd86c819c
Publikováno v:
Psychiatry Research. 245:36-44
Post-traumatic stress disorder (PTSD) is a common and potentially disabling disorder that develops in 1/5 to 1/3 of people exposed to severe trauma. Twin studies indicate that genetic factors account for at least one third of the variance in the risk
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46677455599bdcd215b770b83d6ece33
https://doi.org/10.1016/j.psychres.2016.07.045
https://doi.org/10.1016/j.psychres.2016.07.045
Autor:
Osigbemhe Iyalomhe, Thomas O. Obisesan, Sheree M. Johnson, Oyonumo Ntekim, Yuanxiu Chen, Vernon Bond, Joanne S. Allard, James Li, David Goerlitz
Publikováno v:
Experimental Gerontology. 69:159-169
There is considerable support for the view that aerobic exercise may confer cognitive benefits to mild cognitively impaired elderly persons. However, the biological mechanisms mediating these effects are not entirely clear. As a preliminary step towa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fdbbd8a4e447ed0db1e47cb96ce67a59
Autor:
Oyonumo Ntekim, Osigbemhe Iyalomhe, Sabina Swierczek, Yuanxiu Chen, Philip Kurian, Kakra Hughes, Monica O. Adedeji, Ngozi Enwerem, Joanne S. Allard, Sheree M. Johnson, Thomas O. Obisesan
Neuroinflammation and reactive oxygen species are thought to mediate the pathogenesis of Alzheimer’s disease (AD), suggesting that mild cognitive impairment (MCI), a prodromal stage of AD, may be driven by similar insults. Several studies document
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ee93992261770202c4651fc4fd3fe0a
https://europepmc.org/articles/PMC5435557/
https://europepmc.org/articles/PMC5435557/
Publikováno v:
Journal of sleep research. 26(4)
Compromised sleep and increased sympathetic nervous system (SNS) activity are implicated in the pathogenesis of, and disparities in, cardiovascular disease. Parasympathetic dominance during sleep may be important for cardiovascular health. Sleep and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::705286813ec2da80e0d75cdf2f0e65e4
https://pubmed.ncbi.nlm.nih.gov/28211138
https://pubmed.ncbi.nlm.nih.gov/28211138
Publikováno v:
Bioscience, Biotechnology, and Biochemistry. 74:2050-2055
Aspartyl aminopeptidase (DAP), encoded by the DNPEP gene, is believed to be a cytosolic protein with high enzymatic activity in the neuroendocrine tissues. Bioinformatic analysis revealed that the genomic segment spanning the DNPEP gene is evolutiona
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10adab622d00cf7bb98e770ddc1675c5
https://doi.org/10.1271/bbb.100349
https://doi.org/10.1271/bbb.100349
Autor:
Ayo Doumatey, Steinunn Gunnarsdottir, Helmut Schäfer, Snæbjörn Pálsson, Torben Jørgensen, Torben Hansen, Robert L. Wilensky, Claus Christiansen, Guanjie Chen, Johannes Hebebrand, Kari Stefansson, Gudmar Thorleifsson, Valur Emilsson, Augustine Kong, Yu Z. Bagger, Rafn Benediktsson, Gitte Andersen, Charles N. Rotimi, Agnar Helgason, Struan F.A. Grant, Mezbah U. Faruque, Gunnar Sigurdsson, Oluf Pedersen, Anke Hinney, Yuanxiu Chen, Daniel J. Rader, Knut Borch-Johnsen, Unnur Thorsteinsdottir, Muredach P. Reilly, Jie Zhou, Adebowale Adeyemo, Inga Reynisdottir, Jeffrey R. Gulcher
Publikováno v:
Nature Genetics. 39:218-225
We recently described an association between risk of type 2diabetes and variants in the transcription factor 7-like 2 gene (TCF7L2; formerly TCF4), with a population attributable risk (PAR) of 17%-28% in three populations of European ancestry. Here,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ca1943d2f7c3f22f0e92a5b28eebf71
https://doi.org/10.1038/ng1960
https://doi.org/10.1038/ng1960
Autor:
Valur Emilsson, Shyamali Ghosh, Yuanxiu Chen, Unnur Styrkarsdottir, Ayo Doumatey, Mark E. Gurney, Juliana C.N. Chan, Kerrie Lashley, Adebowale Adeyemo, Augustine Kong, Kari Stefansson, Inga Reynisdottir, Gunnar Sigurdsson, Marten H. Hofker, Jeffrey R. Gulcher, Oluf Pedersen, Cisca Wijmenga, Hjordis Bjarnason, Wing-Yee So, Torben Hansen, Daniel J. Rader, Thorbjorg Jonsdottir, Knut Borch-Johnsen, Valgerdur Steinthorsdottir, Claus Christiansen, Guanjie Chen, Charles N. Rotimi, Gudmar Thorleifsson, Rafn Benediktsson, Torben Jørgensen, Robert L. Wilensky, Vilmundur Gudnason, Hanxia Huang, Unnur Thorsteinsdottir, Muredach P. Reilly, Adam Baker, Yu Z. Bagger, Gitte Andersen, Steinunn Snorradottir, Jana V. van Vliet-Ostaptchouk, G. Bragi Walters, Ronald Ching-Wa Ma, Jie Zhou, Maggie C.Y. Ng, Solveig Gretarsdottir
Publikováno v:
Nature Genetics, 39(6), 770-775. Nature Publishing Group
We conducted a genome-wide association study for type 2 diabetes (T2D) in Icelandic cases and controls, and we found that a previously described variant in the transcription factor 7-like 2 gene (TCF7L2) gene conferred the most significant risk. In a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f7f08f970e64f0526760d315bec751e
https://doi.org/10.1038/ng2043
https://doi.org/10.1038/ng2043
Autor:
Thomas O. Obisesan, Yuanxiu Chen
Publikováno v:
Alzheimer's & Dementia. 11
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b0092e933351e62582c66c6a638062fd
https://doi.org/10.1016/j.jalz.2015.06.892
https://doi.org/10.1016/j.jalz.2015.06.892
Publikováno v:
Molecular & Cellular Biomechanics; 2019, Vol. 16 Issue 3, p199-210, 12p