Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Yuanjun Shi"'
Publikováno v:
IEEE Access, Vol 11, Pp 141703-141722 (2023)
Decision-making problems are often characterized by complexity and uncertainty, presenting significant challenges for individuals or organizations. Aczel Alsina t-norm (TN) and t-conorm (TCN) are more flexible than other TN and TCN due to their varia
Externí odkaz:
https://doaj.org/article/4b7d4b39c9bb4bd38f7d4cfe4ad63bc9
Autor:
Federica Maschietto, Tianyin Qiu, Jimin Wang, Yuanjun Shi, Brandon Allen, George P. Lisi, Elias Lolis, Victor S. Batista
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 21, Iss , Pp 1066-1076 (2023)
The receptor-binding domains (RBDs) of the SARS-CoV-2 spike trimer exhibit ''up'' and ''down'' conformations often targeted by neutralizing antibodies. Only in the “up” configuration can RBDs bind to the ACE2 receptor of the host cell and initiat
Externí odkaz:
https://doaj.org/article/5916798c559645fa85848f4bb9e34d7b
Autor:
Siyuan Mi, Yongjie Tang, Gerile Dari, Yuanjun Shi, Jinning Zhang, Hailiang Zhang, Xueqin Liu, Yibing Liu, Usman Tahir, Ying Yu
Publikováno v:
Journal of Animal Science and Biotechnology, Vol 12, Iss 1, Pp 1-17 (2021)
Abstract Background Staphylococcus aureus (S. aureus) mastitis is one of the most difficult diseases to treat in lactating dairy cows worldwide. S. aureus with different lineages leads to different host immune responses. Long non-coding RNAs (lncRNAs
Externí odkaz:
https://doaj.org/article/e0814b437167491ab5b6c0aea4f8df6c
Autor:
Alger M. Fredericks, Kyle W. East, Yuanjun Shi, Jinchan Liu, Federica Maschietto, Alfred Ayala, William G. Cioffi, Maya Cohen, William G. Fairbrother, Craig T. Lefort, Gerard J. Nau, Mitchell M. Levy, Jimin Wang, Victor S. Batista, George P. Lisi, Sean F. Monaghan
Publikováno v:
Frontiers in Molecular Biosciences, Vol 9 (2022)
Variants of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) continue to cause disease and impair the effectiveness of treatments. The therapeutic potential of convergent neutralizing antibodies (NAbs) from fully recovered patients has be
Externí odkaz:
https://doaj.org/article/4d572fd4d5154c16ba5a156cd43dae53
Publikováno v:
Frontiers in Molecular Biosciences, Vol 9 (2022)
The mechanism of remdesivir incorporation into the RNA primer by the RNA-dependent RNA polymerase (RdRp) of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) remains to be fully established at the molecular level. Here, we compare molecula
Externí odkaz:
https://doaj.org/article/c7b38b2201464e71bd963b8e04b93be4
Autor:
Jimin Wang, Yuanjun Shi, Krystle Reiss, Federica Maschietto, Elias Lolis, William H. Konigsberg, George P. Lisi, Victor S. Batista
Publikováno v:
Biochemistry. 61:1966-1973
Remdesivir is an adenosine analogue that has a cyano substitution in the C1' position of the ribosyl moiety and a modified base structure to stabilize the linkage of the base to the C1' atom with its strong electron-withdrawing cyano group. Within th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6296e0f3d24eb8b117db2d90b346328
https://doi.org/10.1021/acs.biochem.2c00341
https://doi.org/10.1021/acs.biochem.2c00341
Autor:
David B. Agus, Iain J. Webb, Yuanjun Shi, Mitchell E. Gross, John Hainsworth, Omid Hamid, Gary R. MacVicar, Lowell Hart, Daniel Shevrin, Walter M. Stadler, Ajit Suri, David MacLean, Robert Dreicer
Purpose: The androgen receptor pathway remains active in men with prostate cancer whose disease has progressed following surgical or medical castration. Orteronel (TAK-700) is an investigational, oral, nonsteroidal, selective, reversible inhibitor of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b8e4b1833b7f3adbaa2d02c839a5788
https://doi.org/10.1158/1078-0432.c.6521592
https://doi.org/10.1158/1078-0432.c.6521592
Autor:
David B. Agus, Iain J. Webb, Yuanjun Shi, Mitchell E. Gross, John Hainsworth, Omid Hamid, Gary R. MacVicar, Lowell Hart, Daniel Shevrin, Walter M. Stadler, Ajit Suri, David MacLean, Robert Dreicer
PDF file - 65K, Schedule of assessments.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64346251ea584c498f27c381ff4abcc0
https://doi.org/10.1158/1078-0432.22449246.v1
https://doi.org/10.1158/1078-0432.22449246.v1
Autor:
Jimin Wang, Yuanjun Shi, Krystle Reiss, Brandon Allen, Federica Maschietto, Elias Lolis, William H. Konigsberg, George P. Lisi, Victor S. Batista
Publikováno v:
Biochemistry. 61:424-432
A minimal replication-transcription complex (RTC) of SARS-CoV-2 for synthesis of viral RNAs includes the nsp12 RNA-dependent RNA polymerase and two nsp8 RNA primase subunits for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2189129e0b2373f6747c690fbad2040
https://doi.org/10.1021/acs.biochem.1c00755
https://doi.org/10.1021/acs.biochem.1c00755
Publikováno v:
Biochemistry
Remdesivir is an antiviral drug initially designed against the Ebola virus. The results obtained with it both in biochemical studies in vitro and in cell line assays in vivo were very promising, but it proved to be ineffective in clinical trials. Rem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5972d77969cfb19e78b4464d2499e480
https://doi.org/10.1021/acs.biochem.1c00292
https://doi.org/10.1021/acs.biochem.1c00292