Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Yuanjun, Guan"'
Autor:
Senyu Yao, Mao Pang, Yanheng Wang, Xiaokang Wang, Yaobang Lin, Yanyan Lv, Ziqi Xie, Jianfeng Hou, Cong Du, Yuan Qiu, Yuanjun Guan, Bin Liu, Jiancheng Wang, Andy Peng Xiang, Limin Rong
Publikováno v:
Redox Biology, Vol 67, Iss , Pp 102871- (2023)
Ferroptosis is a newly discovered form of iron-dependent oxidative cell death and drives the loss of neurons in spinal cord injury (SCI). Mitochondrial damage is a critical contributor to neuronal death, while mitochondrial quality control (MQC) is a
Externí odkaz:
https://doaj.org/article/de329edaf1b84823bfeb46a840b31ba8
Autor:
Senyu Yao, Xiaoyue Wei, Wenrui Deng, Boyan Wang, Jianye Cai, Yinong Huang, Xiaofan Lai, Yuan Qiu, Yi Wang, Yuanjun Guan, Jiancheng Wang
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
The regulatory mechanisms contributing to male reproductive ageing are unknown. Here, the authors show that Nestin-dependent mito-ER contacts (MERCs) regulate stem Leydig cell (SLC) senescence and provide insights into SLCs-targeting therapies.
Externí odkaz:
https://doaj.org/article/2845439343764e1fba6f73eab2348679
Autor:
Boyan Wang, Yi Wang, Hainan Chen, Senyu Yao, Xiaofan Lai, Yuan Qiu, Jianye Cai, Yinong Huang, Xiaoyue Wei, Yuanjun Guan, Tao Wang, Jiancheng Wang, Andy Peng Xiang
Publikováno v:
Stem Cell Research & Therapy, Vol 12, Iss 1, Pp 1-17 (2021)
Abstract Background Cancer cachexia is a wasting syndrome that is quite common in terminal-stage cancer patients. Cancer-related anemia is one of the main features of cancer cachexia and mostly results in a poor prognosis. The disadvantages of the cu
Externí odkaz:
https://doaj.org/article/be482fd51d0c493ba40c226677da0c70
Autor:
Jiancheng Wang, Qiying Lu, Jianye Cai, Yi Wang, Xiaofan Lai, Yuan Qiu, Yinong Huang, Qiong Ke, Yanan Zhang, Yuanjun Guan, Haoxiang Wu, Yuanyuan Wang, Xin Liu, Yue Shi, Kang Zhang, Maosheng Wang, Andy Peng Xiang
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-17 (2019)
Loss of Nestin sensitizes non-small cell lung carcinoma (NSCLC) to oxidative stress. Here, the authors report a feedback loop between Nestin and Nrf2 wherein Nestin competes with Nrf2 for Keap1 binding, preventing Nrf2 degradation, and show the Nesti
Externí odkaz:
https://doaj.org/article/b1b00c42536b4061b50abe0984df2505
Autor:
Yanan Zhang, Jiancheng Wang, Weijun Huang, Jianye Cai, Junhui Ba, Yi Wang, Qiong Ke, Yinong Huang, Xin Liu, Yuan Qiu, Qiying Lu, Xin Sui, Yue Shi, Tao Wang, Huiyong Shen, Yuanjun Guan, Ying Zhou, Yuan Chen, Maosheng Wang, Andy Peng Xiang
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
Nestin can be localised in the nucleus of cancer cells, but its nuclear role in tumorigenesis is unclear. Here, the authors show that nuclear Nestin prevents senescence in tumor cells by stabilising lamin A/C from proteasomal degradation to maintain
Externí odkaz:
https://doaj.org/article/d48c676e77354d918de1fbd1372346c0
Autor:
Xiancai Ma, Tao Yang, Yuewen Luo, Liyang Wu, Yawen Jiang, Zheng Song, Ting Pan, Bingfeng Liu, Guangyan Liu, Jun Liu, Fei Yu, Zhangping He, Wanying Zhang, Jinyu Yang, Liting Liang, Yuanjun Guan, Xu Zhang, Linghua Li, Weiping Cai, Xiaoping Tang, Song Gao, Kai Deng, Hui Zhang
Publikováno v:
eLife, Vol 8 (2019)
Comprehensively elucidating the molecular mechanisms of human immunodeficiency virus type 1 (HIV-1) latency is a priority to achieve a functional cure. As current 'shock' agents failed to efficiently reactivate the latent reservoir, it is important t
Externí odkaz:
https://doaj.org/article/4fbaafbcadd840f6a56c48e1b5c9ec7c
Targeting Nestin+ hepatic stellate cells ameliorates liver fibrosis by facilitating TβRI degradation
Autor:
Qiuli Liu, Gui-hua Chen, Yang Yang, Qi Zhang, Yi Wang, Chenhao Jiang, Lijie Pan, Jun Zheng, Yuanjun Guan, Jianye Cai, Guo lv, Yan Xu, Cong Du, Chenju Yi, Yuan Qiu, Jiancheng Wang, Yiqin Wang, Andy Peng Xiang, Huaxin Chen, Dongbo Qiu
Publikováno v:
Journal of Hepatology. 74:1176-1187
Background & Aims Liver fibrosis is a wound healing response that arises from various aetiologies. The intermediate filament protein Nestin has been reported to participate in maintaining tissue homeostasis during wound healing responses. However, li
Autor:
Liyang Wu, Ting Pan, Mo Zhou, Tao Chen, Shiyu Wu, Xi Lv, Jun Liu, Fei Yu, Yuanjun Guan, Bingfeng Liu, Wanying Zhang, Xiaohui Deng, Qianyu Chen, Anqi Liang, Yingtong Lin, Lilin Wang, Xiaoping Tang, Weiping Cai, Linghua Li, Xin He, Hui Zhang, Xiancai Ma
Publikováno v:
EMBO Rep
The retrovirus HIV‐1 integrates into the host genome and establishes a latent viral reservoir that escapes immune surveillance. Molecular mechanisms of HIV‐1 latency have been studied extensively to achieve a cure for the acquired immunodeficienc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5123ecf24fdb451b7521874181516c7
https://europepmc.org/articles/PMC9253744/
https://europepmc.org/articles/PMC9253744/
Autor:
Senyu Yao, Xiaoyue Wei, Wenrui Deng, Boyan Wang, Jianye Cai, Yinong Huang, Xiaofan Lai, Yuan Qiu, Yi Wang, Yuanjun Guan, Jiancheng Wang
Publikováno v:
Nature communications. 13(1)
Male reproductive system ageing is closely associated with deficiency in testosterone production due to loss of functional Leydig cells, which are differentiated from stem Leydig cells (SLCs). However, the relationship between SLC differentiation and
Autor:
Yuanjun Guan, Hui Zhang, Ziwen Wang, Xu Zhang, Ting Pan, Zhilin Peng, Tao Chen, Jun Liu, Tao Yang, Yingtong Lin, Xiaoping Tang, Xiancai Ma, Linghua Li, Mo Zhou, Zhonghui Tang, Liyang Wu, Guangyan Liu, Muye Tong
Publikováno v:
EMBO J
HIV‐1 latency is a major obstacle to achieving a functional cure for AIDS. Reactivation of HIV‐1‐infected cells followed by their elimination via immune surveillance is one proposed strategy for eradicating the viral reservoir. However, current