Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Yuanjian Guo"'
Autor:
Urszula Golebiewska, Yuanjian Guo, Narindra Khalikaprasad, Cassandra Zurawsky, V Siddhartha Yerramilli, Suzanne Scarlata
Publikováno v:
PLoS ONE, Vol 7, Iss 8, p e41067 (2012)
Phospholipase Cβ2 (PLC β2) is activated by G proteins and generates calcium signals in cells. PLCβ2 is absent in normal breast tissue, but is highly expressed in breast tumors where its expression is correlated with the progression and migration o
Externí odkaz:
https://doaj.org/article/d24bf04e015c438db5873ff9a896c58c
Autor:
Suzanne Scarlata, Urszula Golebiewska, Osama Garwain, Finly Philip, Shriya Sahu, Imanol Gonzalez Burguera, Leo Williams, Yuanjian Guo, Barbara Rosati
Publikováno v:
Advances in Biological Regulation. 61:51-57
Phosphoinositide-specific-phospholipase Cβ (PLCβ) is the main effector of Gαq stimulation which is coupled to receptors that bind acetylcholine, bradykinin, dopamine, angiotensin II as well as other hormones and neurotransmitters. Using a yeast tw
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c2f96412c6bcf3f367dee45bcdd62f4
https://doi.org/10.1016/j.jbior.2015.11.006
https://doi.org/10.1016/j.jbior.2015.11.006
Publikováno v:
Stem Cells Translational Medicine. 4:476-482
Stem cell therapy requires a nontoxic and high-throughput method to achieve a pure cell population to prevent teratomas that can occur if even one cell in the implant has not been transformed. A promising method to detect and separate cells expressin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7bd915657e8403add63c2cfa0c327704
https://doi.org/10.5966/sctm.2014-0166
https://doi.org/10.5966/sctm.2014-0166
Autor:
Golebiewska, Urszula1,2, Yuanjian Guo1, Khalikaprasad, Narindra1, Zurawsky, Cassandra1, Yerramilli, V. Siddhartha1, Scarlata, Suzanne1 Suzanne.Scarlata@sunysb.edu, Uversky, Vladimir N.3
Publikováno v:
PLoS ONE. Aug2012, Vol. 7 Issue 8, Special section p1-8. 8p.
Autor:
Yuanjian Guo, Suzanne Scarlata
Publikováno v:
Biochemistry. 52:3913-3920
There is a consensus that oxidative stress promotes neurodegeneration and may be linked to plaque formation. α-Synuclein is the main component of neurodegenerative plaques. We have found that α-synuclein binds strongly to the enzyme phospholipase C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f102688b4d03e948f0c857939ba0af0
https://doi.org/10.1021/bi4002425
https://doi.org/10.1021/bi4002425
Publikováno v:
Cellular Signalling. 24:1109-1114
α-Synuclein is a conserved protein that is a key component in neurodegenerative plaques [1,2]. α-Synuclein binds strongly to phospholipase Cβ (PLCβ) and promotes Ca2+ release in cells. Here, we show that expression of α-synuclein increases the c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4a6c02bad96b020b34f08bf080b5194
https://doi.org/10.1016/j.cellsig.2012.01.007
https://doi.org/10.1016/j.cellsig.2012.01.007
Publikováno v:
Journal of Biological Chemistry. 284:16906-16913
It is well known that Gαi1(GDP) binds strongly to Gβγ subunits to form the Gαi1(GDP)-Gβγ heterotrimer, and that activation to Gαi1(GTP) results in conformational changes that reduces its affinity for Gβγ subunits. Previous studies of G prote
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::69aaf77f9f37418a29c30b23cae3ca14
https://doi.org/10.1074/jbc.m109.006585
https://doi.org/10.1074/jbc.m109.006585
Publikováno v:
The Journal of biological chemistry. 290(27)
Caveolae are membrane invaginations that can sequester various signaling proteins. Caveolae have been shown to provide mechanical strength to cells by flattening to accommodate increased volume when cells are subjected to hypo-osmotic stress. We have
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12cc2a7e793a848c51b3f84b741c6f13
https://pubmed.ncbi.nlm.nih.gov/25957403
https://pubmed.ncbi.nlm.nih.gov/25957403
Publikováno v:
Journal of Biological Chemistry. 280:1438-1447
Phospholipase Cβ (PLCβ) isoforms, which are under the control of Gαq and Gβγ subunits, generate Ca2+ signals induced by a broad array of extracellular agonists, whereas PLCδ isoforms depend on a rise in cytosolic Ca2+ for their activation. Here
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c638d9e04a22227808e25a8d905de270
https://doi.org/10.1074/jbc.m407593200
https://doi.org/10.1074/jbc.m407593200
Autor:
Markus Frings, Paschal A. Oude Weernink, Marie-Luise Mono, Martina Schmidt, Yuanjian Guo, Karl Jakobs, Sandrine Evellin, Li Han
Publikováno v:
Journal of Biological Chemistry. 275:32603-32610
Activation of stably expressed M(2) and M(3) muscarinic acetylcholine receptors (mAChRs) as well as of endogenously expressed lysophosphatidic acid and purinergic receptors in HEK-293 cells can induce a long lasting potentiation of phospholipase C (P
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca2452a38c3cbdbeb5c9054b1a3c7c82
https://doi.org/10.1074/jbc.m004784200
https://doi.org/10.1074/jbc.m004784200