Zobrazeno 1 - 10
of 98
pro vyhledávání: '"Yuanjia, Tang"'
Autor:
Zhongzhen Li, Zhiwei Lei, Wanying Yang, Chunxia Jing, Xiaolin Sun, Guang Yang, Xiaozhen Zhao, Mingjiao Zhang, Miaomiao Xu, Yuanjia Tang, Qingwen Wang, Jing Zhao, Zixing Zhou, Zihao Wen, Xiaojing Chen, Qinglin Peng, Guochun Wang, Pingjing Zhang, Erwei Sun, Nan Shen, Weiguo Xu, Zhanguo Li, Hengwen Yang, Zhinan Yin
Publikováno v:
Parasites & Vectors, Vol 17, Iss 1, Pp 1-8 (2024)
Abstract Background Systemic lupus erythematosus (SLE) is a complex systemic autoimmune disease characterized by the presence of numerous autoantibodies. The interaction of infectious agents (viruses, bacteria and parasites) and a genetically suscept
Externí odkaz:
https://doaj.org/article/0bb8607a37224c6a8303f613d47af5e2
Autor:
Weiwen Shi, Mengke Chen, Tingting Pan, Mengjie Chen, Yongjun Cheng, Yimei Hao, Sheng Chen, Yuanjia Tang
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-15 (2023)
Abstract The role of host genetic factors in COVID-19 outcomes remains unclear despite various genome-wide association studies (GWAS). We annotate all significant variants and those variants in high LD (R2 > 0.8) from the COVID-19 host genetics initi
Externí odkaz:
https://doaj.org/article/56ca75da8d514d7ba9400faaa0fd9ebe
Autor:
Shunxiang Li, Huihua Ding, Ziheng Qi, Jing Yang, Jingyi Huang, Lin Huang, Mengji Zhang, Yuanjia Tang, Nan Shen, Kun Qian, Qiang Guo, Jingjing Wan
Publikováno v:
Advanced Science, Vol 11, Iss 2, Pp n/a-n/a (2024)
Abstract Metabolic fingerprints in serum characterize diverse diseases for diagnostics and biomarker discovery. The identification of systemic lupus erythematosus (SLE) by serum metabolic fingerprints (SMFs) will facilitate precision medicine in SLE
Externí odkaz:
https://doaj.org/article/30082c91649444028b3d89fa9b283646
Autor:
Tian Zhou, Xinyi Zhu, Zhizhong Ye, Yong-Fei Wang, Chao Yao, Ning Xu, Mi Zhou, Jianyang Ma, Yuting Qin, Yiwei Shen, Yuanjia Tang, Zhihua Yin, Hong Xu, Yutong Zhang, Xiaoli Zang, Huihua Ding, Wanling Yang, Ya Guo, John B. Harley, Bahram Namjou, Kenneth M. Kaufman, Leah C. Kottyan, Matthew T. Weirauch, Guojun Hou, Nan Shen
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
The functional effects of genetic loci associated with autoimmune disease are not well understood. By dissecting an autoimmune disease genetic locus, the authors define an immune cell-type-specific enhancer and the molecular mechanisms underlying the
Externí odkaz:
https://doaj.org/article/b834bed781e544609a560d62e4f3795e
Autor:
Yong-Fei Wang, Yan Zhang, Zhiming Lin, Huoru Zhang, Ting-You Wang, Yujie Cao, David L. Morris, Yujun Sheng, Xianyong Yin, Shi-Long Zhong, Xiaoqiong Gu, Yao Lei, Jing He, Qi Wu, Jiangshan Jane Shen, Jing Yang, Tai-Hing Lam, Jia-Huang Lin, Zhi-Ming Mai, Mengbiao Guo, Yuanjia Tang, Yanhui Chen, Qin Song, Bo Ban, Chi Chiu Mok, Yong Cui, Liangjing Lu, Nan Shen, Pak C. Sham, Chak Sing Lau, David K. Smith, Timothy J. Vyse, Xuejun Zhang, Yu Lung Lau, Wanling Yang
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
The presentation of systemic lupus erythematosus has been known to differ by ancestry, but the underlying genetic factors remain unclear. Here, the authors report ancestry-specific susceptibility loci and better risk prediction when using data from m
Externí odkaz:
https://doaj.org/article/783362c0f8c8422595f0ff721e5c39ef
Autor:
Jianxin Zheng, Hong Zhou, Taihua Yang, Jinchuan Liu, Tian Qin, Xiangqian Gu, Ji Wu, Yi Zhang, Honglin Wang, Yuanjia Tang, Feng Xue, Yimin Mao, Qiang Xia
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 12, Iss 5, Pp 1789-1807 (2021)
Background & Aims: Sustained c-Jun N-terminal kinase (JNK) activation plays a major role in drug-induced liver injury (DILI). Stress-responsive microRNA-31 (miR-31) has been implicated in regulating different cellular damage, and JNK activation could
Externí odkaz:
https://doaj.org/article/beabaa901cb04e698d21b5567b0393e5
Autor:
Guojun Hou, Isaac T. W. Harley, Xiaoming Lu, Tian Zhou, Ning Xu, Chao Yao, Yuting Qin, Ye Ouyang, Jianyang Ma, Xinyi Zhu, Xiang Yu, Hong Xu, Dai Dai, Huihua Ding, Zhihua Yin, Zhizhong Ye, Jun Deng, Mi Zhou, Yuanjia Tang, Bahram Namjou, Ya Guo, Matthew T. Weirauch, Leah C. Kottyan, John B. Harley, Nan Shen
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
Enhancers shape gene expression patterns and are involved in disease pathogenesis. Here the authors demonstrate a strategy to screen functional regulatory elements for non-coding RNAs ― illustrated with miR-146a ― and link autoimmune disease risk
Externí odkaz:
https://doaj.org/article/de8dfa40a050458585327f2085f7931f
Autor:
Youwei Zhu, Zhaoyang Zhang, Jia Song, Weizhou Qian, Xiangqian Gu, Chaoyong Yang, Nan Shen, Feng Xue, Yuanjia Tang
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Infection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), causing the rapid spread of coronavirus disease 2019 (COVID-19), has generated a public health crisis worldwide. The molecular mechanisms of SARS-CoV-2 infection and virus–h
Externí odkaz:
https://doaj.org/article/17e8765e53204f819c123d83a77b4be4
Publikováno v:
Acta Biochimica et Biophysica Sinica; Feb2024, Vol. 56 Issue 2, p151-161, 11p
Autor:
Jing Zeng, Xinyu Meng, Ping Zhou, Zhihua Yin, Qinglian Xie, Hong Zou, Nan Shen, Zhizhong Ye, Yuanjia Tang
Publikováno v:
Arthritis Research & Therapy, Vol 21, Iss 1, Pp 1-11 (2019)
Abstract Background Neuropsychiatric systemic lupus erythaematosus (NP-SLE) is one of the major manifestations of lupus. However, the mechanisms involved in NP-SLE are still largely unknown. The abnormal activation of the type I IFN signalling pathwa
Externí odkaz:
https://doaj.org/article/68caa76dd9014ab28645a9fef37c2334