Zobrazeno 1 - 10
of 46
pro vyhledávání: '"Yuanhui Mao"'
Publikováno v:
Journal of Functional Foods, Vol 105, Iss , Pp 105570- (2023)
Heart failure with preserved ejection fraction (HFpEF) is typically preceded by cardiac hypertrophy. Lycium barbarum L. as functional food show the health benefits of cardiovascular diseases. Whether Lycium barbarum L. protein-derived angiotensin-con
Externí odkaz:
https://doaj.org/article/daf8308651b14d5c83640f64d5f7f771
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Start codon selection is commonly thought to occur through the unidirectional scanning of the mRNA by the 40 S ribosome. Here the authors provide evidence that the pre-initiation complex can backslide on the mRNA to initiate translation at upstream A
Externí odkaz:
https://doaj.org/article/291d39793d7a4dbc85968755a40300d0
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
Several functions have been proposed for m6A in RNA metabolism, yet little is known regarding the specific functions of individual m6A readers. Here, the authors observe that the m6A reader YTHDC2 — which contains an RNA helicase domain — acts on
Externí odkaz:
https://doaj.org/article/3ca83b1462a8473fb1ee44b8fa43183d
Publikováno v:
Research, Vol 2018 (2018)
Upon initiation at a start codon, the ribosome must maintain the correct reading frame for hundreds of codons in order to produce functional proteins. While some sequence elements are able to trigger programmed ribosomal frameshifting (PRF), very lit
Externí odkaz:
https://doaj.org/article/95977698aa2a476c98b4121363bb6bbb
Publikováno v:
PLoS ONE, Vol 10, Iss 12, p e0145887 (2015)
By introducing synonymous mutations into the coding sequences of GP64sp and FibHsp signal peptides, the influences of mRNA secondary structure and codon usage of signal sequences on protein expression and secretion were investigated using baculovirus
Externí odkaz:
https://doaj.org/article/796a9fa6237644b99b338af98c2b0dc5
Publikováno v:
PLoS ONE, Vol 9, Iss 4, p e94899 (2014)
F-box proteins are substrate adaptors used by the SKP1-CUL1-F-box protein (SCF) complex, a type of E3 ubiquitin ligase complex in the ubiquitin proteasome system (UPS). SCF-mediated ubiquitylation regulates proteolysis of hundreds of cellular protein
Externí odkaz:
https://doaj.org/article/60151551cd3d4ac5af1f18eaa38928c5
Publikováno v:
PLoS ONE, Vol 8, Iss 9, p e73299 (2013)
Message RNA (mRNA) carries a large number of local secondary structures, with structural stability to participate in the regulations of gene expression. A worthy question is how the local structural stability is maintained under the constraint that m
Externí odkaz:
https://doaj.org/article/cf90c08e1f97428088ffbb1474e51c17
Publikováno v:
PLoS ONE, Vol 7, Iss 9, p e44376 (2012)
Understanding intra-molecular coevolution helps to elucidate various structural and functional constraints acting on molecules and might have practical applications in predicting molecular structure and interactions. In this study, we used 5S rRNA as
Externí odkaz:
https://doaj.org/article/f3b183c63f3949618087a8af02a4d05c
Autor:
Yuanhui Mao, Shu-Bing Qian
Publikováno v:
Seminars in Cell & Developmental Biology.
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Nature Communications
Nature Communications
The fidelity of start codon recognition by ribosomes is paramount during protein synthesis. The current knowledge of eukaryotic translation initiation implies unidirectional 5ʹ→3ʹ migration of the pre-initiation complex (PIC) along the 5ʹ UTR. I