Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Yuanhu Mao"'
Autor:
Li Dong, Shanhui Zhang, Lina Chen, Jun Lu, Fuhui Zhao, Tiemei Long, Jinlan Wen, Jiayu Huang, Yuanhu Mao, Zhengfang Qi, Jiquan Zhang, Lei Li, Yongxi Dong
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 161, Iss , Pp 114532- (2023)
The incidence of hyperuricemia and gout has been increasing year by year, and it is showing a younger trend. However, the first-line drugs currently used for hyperuricemia and gouty arthritis have serious side effects that limit their clinical applic
Externí odkaz:
https://doaj.org/article/b712111cbdac44eebd5aa8cdd3b0dfbd
Autor:
Zhanzhan Yang, Gang Liu, Jia-Yu Huang, Lei Li, Jiquan Zhang, Shang-Gao Liao, Yuanhu Mao, Li Dong, Shu-Xia Wu, Ming-Ji Liu, Yongxi Dong
Publikováno v:
Medicinal Chemistry Research. 31:75-84
Tetramethylpyrazine (TMP) is commonly used as an antiplatelet drug in clinic. However, the short half-life and low bioavailability limited its applications. 3, 5, 6-Trimethylpyrazine-2-carboxAylic acid (TMP-COOH) and 2-hydroxy-3, 5, 6-trimethylpyrazi
Autor:
Ji-Quan Zhang, Yuan-Yong Yang, Fei Cheng, Gao-Feng Zhu, Li-Li Wang, Lei Tang, Bin Liu, Yuanhu Mao, Bing Guo, Yong-Xi Dong
Publikováno v:
The Journal of Organic Chemistry. 86:8620-8629
An efficient aerobic iron-catalyzed annulation of unsaturated carboxylic acids with disulfides has been developed. This procedure proceeds using FeCl3 as the catalyst and KI as an iodine source under an air atmosphere, which provides practical access
Autor:
Xiao-Zhong Fu, Fen-Fen Yang, Chun Li, Yuanhu Mao, Meng Zhou, Yong-Long Zhao, Yong-Xi Dong, Yong-Qin Tang, Bin He, Peng-Fei Xu, Yuan-Yong Yang, Xing-Hai Fei
Publikováno v:
The Journal of organic chemistry. 84(12)
An organocatalytic asymmetric α-sulfenylation of 2-substituted indolin-3-ones with N-(alkylthio or arylthio)succinimides has been developed for the first time using Cinchona-derived squaramide as the catalyst. Various chiral 2,2-disubstituted indole
Autor:
Yuanhu Mao, Ting Guo, Mingji Liu, Yang Yang, Jinglei Chen, Xiaohe Zhang, Yongxi Dong, Chunhua Qiao, Xiao-Zhong Fu, Jiquan Zhang, Li Dong, Yong-Long Zhao
Publikováno v:
Bioorganicmedicinal chemistry letters. 29(19)
A series of hybrid molecules of scutellarein and tertramethylpyrazine's active metabolites have been synthesized. Compared to the original compound, these prepared compounds exhibited higher water solubility, more appropriate logP and better stabilit
Autor:
Shuiying Wan, Lei Tang, Ying-Xian Li, Yuanhu Mao, Lin Zhang, Guo Yang, Yuan-Yong Yang, Yong-Long Zhao, Chun Li, Ji-Quan Zhang, Cheng Cheng
Publikováno v:
The Journal of organic chemistry. 84(4)
Base-catalyzed efficient hydroxylation of isoquinoline-1,3(2 H,4 H)-diones with air under transition-metal-free and reductant-free conditions was established. This methodology is essentially mild and compatible with a broad range of substrates, inclu
Autor:
Ji-Quan Zhang, Lei Tang, Yao Du, Yuanhu Mao, Li-Li Wang, Jing Huang, Qingqing Guo, Jian-Ta Wang, Zi-Li Chen, Ling Wang, Ting-Ting Wu, Rui Chen, Sheng-Gang Yang
Publikováno v:
European Journal of Medicinal Chemistry. 204:112637
A series of novel substituted triazines bearing a benzimidazole scaffold were designed and synthesized based on the structures of known anti-cancer agents, namely gedatolisib and alpelisib. All the target compounds were screened for inhibitory activi
Publikováno v:
Catalysis Communications. 82:29-31
Pentanidium catalyzed enantioselective 3-hydroperoxidation of 2-oxindoles with molecular oxygen has been established. Various 3-hydroperoxy-2-oxindoles were achieved in good ee and yield.