Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Yuanhan Wu"'
Engaging student opinions on vaccine development innovation: Experiences from a 'Shark Tank' project
Autor:
Jeffrey S. Barrett, Jeffrey M. Skolnik, Mary Ingram, Yin‐Ming Kuo, Ann E. Metzloff, Ruizhe Jin, Yuanhan Wu, Nik Kroushl
Publikováno v:
Clinical and Translational Science, Vol 17, Iss 2, Pp n/a-n/a (2024)
Abstract A graduate course on vaccine development challenged students to propose concepts to improve upon current vaccine development paradigms in the context of a “Shark Tank‐style” format where students were asked to develop an abbreviated bu
Externí odkaz:
https://doaj.org/article/827811e1583e479aaba38c98a1c05be4
Autor:
Nicholas J. Tursi, Ziyang Xu, Michaela Helble, Susanne Walker, Kevin Liaw, Neethu Chokkalingam, Toshitha Kannan, Yuanhan Wu, Edgar Tello-Ruiz, Daniel H. Park, Xizhou Zhu, Megan C. Wise, Trevor R. F. Smith, Sonali Majumdar, Andrew Kossenkov, Daniel W. Kulp, David B. Weiner
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Cancer immunotherapy has demonstrated great promise with several checkpoint inhibitors being approved as the first-line therapy for some types of cancer, and new engineered cytokines such as Neo2/15 now being evaluated in many studies. In this work,
Externí odkaz:
https://doaj.org/article/dc3a4e20f8a14ad0a03f68a1e21315d0
Autor:
Ziyang Xu, Susanne Walker, Megan C. Wise, Neethu Chokkalingam, Mansi Purwar, Alan Moore, Edgar Tello-Ruiz, Yuanhan Wu, Sonali Majumdar, Kylie M. Konrath, Abhijeet Kulkarni, Nicholas J. Tursi, Faraz I. Zaidi, Emma L. Reuschel, Ishaan Patel, April Obeirne, Jianqiu Du, Katherine Schultheis, Lauren Gites, Trevor Smith, Janess Mendoza, Kate E. Broderick, Laurent Humeau, Jesper Pallesen, David B. Weiner, Daniel W. Kulp
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
HIV envelope is a target for vaccine development, but induction of broadly neutralizing antibodies has been difficult. Here, the authors show that electroporation with a synthetic DNA vaccine construct allows in vivo production of HIV envelope native
Externí odkaz:
https://doaj.org/article/35ba9a407faa49de8522273b74f5d21c
Autor:
Trevor R. F. Smith, Ami Patel, Stephanie Ramos, Dustin Elwood, Xizhou Zhu, Jian Yan, Ebony N. Gary, Susanne N. Walker, Katherine Schultheis, Mansi Purwar, Ziyang Xu, Jewell Walters, Pratik Bhojnagarwala, Maria Yang, Neethu Chokkalingam, Patrick Pezzoli, Elizabeth Parzych, Emma L. Reuschel, Arthur Doan, Nicholas Tursi, Miguel Vasquez, Jihae Choi, Edgar Tello-Ruiz, Igor Maricic, Mamadou A. Bah, Yuanhan Wu, Dinah Amante, Daniel H. Park, Yaya Dia, Ali Raza Ali, Faraz I. Zaidi, Alison Generotti, Kevin Y. Kim, Timothy A. Herring, Sophia Reeder, Viviane M. Andrade, Karen Buttigieg, Gan Zhao, Jiun-Ming Wu, Dan Li, Linlin Bao, Jiangning Liu, Wei Deng, Chuan Qin, Ami Shah Brown, Makan Khoshnejad, Nianshuang Wang, Jacqueline Chu, Daniel Wrapp, Jason S. McLellan, Kar Muthumani, Bin Wang, Miles W. Carroll, J. Joseph Kim, Jean Boyer, Daniel W. Kulp, Laurent M. P. F. Humeau, David B. Weiner, Kate E. Broderick
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
There is currently no licensed SARS-CoV-2 vaccine. Here, the authors generate an optimized DNA vaccine candidate encoding the SARS-CoV-2 spike antigen, demonstrating induction of specific T cells and neutralizing antibody responses in mice and guinea
Externí odkaz:
https://doaj.org/article/0814bda6deff4859a14eda518fea5941
Autor:
Morgan L. Nance, Steven J. Bertolani, William R. Schief, Rebecca F. Alford, Daniel W. Kulp, Jason C. Klima, Shourya S. Roy Burman, Yuanhan Wu, Jack Maguire, Jordan R. Willis, Roland L. Dunbrack, Andrew Leaver-Fay, Jason W. Labonte, Aleexsan Adal, Ramya Rangan, Brian Kuhlman, Sergey Lyskov, Jared Adolf-Bryfogle, Justin B. Siegel, Kathy H. Le, Rhiju Das, Jeffrey J. Gray, Brian D. Weitzner, Matt A. Adrianowycz
Publikováno v:
Biophysicist (Rockv)
Biomolecular structure drives function, and computational capabilities have progressed such that the prediction and computational design of biomolecular structures is increasingly feasible. Because computational biophysics attracts students from many
Autor:
Kylie M. Konrath, Kevin Liaw, Yuanhan Wu, Xizhou Zhu, Susanne N. Walker, Ziyang Xu, Katherine Schultheis, Neethu Chokkalingam, Himanshi Chawla, Jianqiu Du, Nicholas J. Tursi, Alan Moore, Jared Adolf-Bryfogle, Mansi Purwar, Emma L. Reuschel, Drew Frase, Matthew Sullivan, Benjamin Fry, Igor Maricic, Viviane M. Andrade, Christel Iffland, Max Crispin, Kate E. Broderick, Laurent M.P.F. Humeau, Ami Patel, Trevor R.F. Smith, Jesper Pallesen, David B. Weiner, Daniel W. Kulp
Publikováno v:
Cell Reports
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines may target epitopes that reduce durability or increase the potential for escape from vaccine-induced immunity. Using synthetic vaccinology, we have developed rationally immune-focu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1496ef22157f363267c3a7c8c0b6c07
https://eprints.soton.ac.uk/455740/
https://eprints.soton.ac.uk/455740/
Autor:
Nicholas J. Tursi, Katherine Schultheis, Emma L. Reuschel, Daniel W. Kulp, Igor Maricic, Laurent Humeau, Susanne Walker, David B. Weiner, Neethu Chokkalingam, Kate E. Broderick, Kylie Konrath, Viviane Machado, Ziyang Xu, Christel Iffland, Jianqiu Du, Trevor Smith, Xizhou Zhu, Jesper Pallesen, Drew Frase, Matthew P. Sullivan, Yuanhan Wu, Alan Moore, Mansi Purwar, Kevin Liaw
Antibodies from SARS-CoV-2 vaccines may target epitopes which reduce durability or increase the potential for escape from vaccine-induced immunity. Using a novel synthetic vaccinology pipeline, we developed rationally immune focused SARS-CoV-2 Spike-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2c0fc8660f4d8a1343e4b53f2bf474f6
https://doi.org/10.1101/2021.04.28.441474
https://doi.org/10.1101/2021.04.28.441474
Autor:
Daniel W. Kulp, Megan C. Wise, Jianqiu Du, Lauren Gites, Jesper Pallesen, Ishaan Patel, Emma L. Reuschel, Trevor R.F. Smith, Edgar Tello-Ruiz, David B. Weiner, Alan Moore, Yuanhan Wu, Mansi Purwar, Ziyang Xu, Kate Broderick, April Obeirne, Susanne Walker, Janess M. Mendoza, Katherine Schultheis, Sonali Majumdar, Faraz I. Zaidi, Neethu Chokkalingam, Laurent H. Humeau
Despite extensive efforts, an efficacious HIV vaccine remains elusive. HIV Envelope (Env) is the target of all known neutralizing antibodies. Stabilizing Env into native-like trimer (NLT) conformations is required for recombinant protein immunogens t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6de08d3e5b89440a423d051730e3b386
https://doi.org/10.21203/rs.3.rs-275402/v1
https://doi.org/10.21203/rs.3.rs-275402/v1
Autor:
Elizabeth Parzych, Alison Generotti, Maria Yang, Chuan Qin, Karen R. Buttigieg, Pratik Bhojnagarwala, Dustin Elwood, Igor Maricic, J. Joseph Kim, Patrick Pezzoli, Arthur Doan, Miguel Vasquez, Edgar Tello-Ruiz, Faraz I. Zaidi, Miles W. Carroll, Yaya Dia, Yuanhan Wu, Daniel Wrapp, Jason S. McLellan, Xizhou Zhu, David B. Weiner, Nicholas J. Tursi, Ami Shah Brown, Emma L. Reuschel, Jacqueline Chu, Ami Patel, Ziyang Xu, Nianshuang Wang, Wei Deng, Daniel W. Kulp, Gan Zhao, Timothy A. Herring, Katherine Schultheis, Susanne Walker, Neethu Chokkalingam, Karuppiah Muthumani, Mamadou A. Bah, Jiun Ming Wu, Laurent Humeau, Linlin Bao, Dinah Amante, Stephanie Ramos, Jihae Choi, Ebony N. Gary, Sophia M. Reeder, Jean D. Boyer, Viviane M Andrade, Bin Wang, Daniel H. Park, Mansi Purwar, Makan Khoshnejad, Jiangning Liu, Kevin Kim, Dan Li, Ali Raza Ali, Kate E. Broderick, Trevor R.F. Smith, Jian Yan, Jewell Walters
Publikováno v:
Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
The coronavirus family member, SARS-CoV-2 has been identified as the causal agent for the pandemic viral pneumonia disease, COVID-19. At this time, no vaccine is available to control further dissemination of the disease. We have previously engineered
Autor:
Arthur Doan, David B. Weiner, Kevin Kim, Elizabeth Parzych, Jean D. Boyer, Yuanhan Wu, Katherine Schultheis, Karuppiah Muthumani, Igor Maricic, Mamadou A. Bah, Miguel Vasquez, Ebony N. Gary, Sophia M. Reeder, Ali Raza Ali, Faraz I. Zaidi, Jewell Walters, Kate E. Broderick, Laurent Humeau, Daniel Park, Xizhou Zhu, Alison Generotti, Stephanie Ramos, Dustin Elwood, Neethu Chokkalingam, Yaya Dia, Makan Khoshnejad, Daniel Wrapp, Susanne Walker, Nicholas J. Tursi, Emma L. Reuschel, Jian Yan, Dinah Amante, Jacqueline Chu, Ami Shah Brown, Nianshuang Wang, Maria Yang, Trevor R.F. Smith, Jason S. McLellan, Ami Patel, Jihae Choi, Timothy A. Herring, J. Joseph Kim, Daniel W. Kulp, Patrick Pezzoli
The coronavirus family member, SARS-CoV-2 has been identified as the causal agent for the outbreak of viral pneumonia disease, COVID-19 which first emerged in mid-December 2019 in the city of Wuhan in central China. As of February 25, 2020 there are
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::50fb943c66e36b9102385bbe7f93c370
https://doi.org/10.21203/rs.3.rs-16261/v1
https://doi.org/10.21203/rs.3.rs-16261/v1