Zobrazeno 1 - 10
of 58
pro vyhledávání: '"Yuanchao Xie"'
Autor:
Yumin Zhang, Yuan Sun, Yuanchao Xie, Weijuan Shang, Zhen Wang, Hualiang Jiang, Jingshan Shen, Gengfu Xiao, Leike Zhang
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 8, Iss 1, Pp 1-10 (2023)
Abstract During the ongoing pandemic, providing treatment consisting of effective, low-cost oral antiviral drugs at an early stage of SARS-CoV-2 infection has been a priority for controlling COVID-19. Although Paxlovid and molnupiravir have received
Externí odkaz:
https://doaj.org/article/891dbeaa644d412cbba032b38ed92b99
Autor:
Huan Xu, Xiaoqin Jian, Yuxi Wen, Mengwei Xu, Runming Jin, Xiaoyan Wu, Fen Zhou, Junyuan Cao, Gengfu Xiao, Ke Peng, Yuanchao Xie, Hongbo Chen, Leike Zhang
Publikováno v:
EBioMedicine, Vol 99, Iss , Pp 104944- (2024)
Summary: Background: Severe fever with thrombocytopenia syndrome virus (SFTSV) is an emerging tick-borne pathogen that causes severe hemorrhagic fever in humans, but no FDA-approved specific antivirals or vaccines are available to treat or prevent SF
Externí odkaz:
https://doaj.org/article/5d74fa6be68a495196b51a43c2d70518
Autor:
Rulei Yang, Yiran Liu, Ning Yang, Tian Zhang, Jiazhen Hou, Zongyan He, Yutong Wang, Xujie Sun, Jingshan Shen, Hualiang Jiang, Yuanchao Xie, Tianqun Lang
Publikováno v:
Pharmaceutics, Vol 16, Iss 4, p 570 (2024)
Colorectal cancer (CRC) ranks as the third most prevalent global malignancy, marked by significant metastasis and post-surgical recurrence, posing formidable challenges to treatment efficacy. The integration of oligonucleotides with chemotherapeutic
Externí odkaz:
https://doaj.org/article/85a8bb3da5b9472b84b7427288e00dc0
Autor:
Ruxue Zhang, Yumin Zhang, Wei Zheng, Weijuan Shang, Yan Wu, Ning Li, Jun Xiong, Hualiang Jiang, Jingshan Shen, Gengfu Xiao, Yuanchao Xie, Leike Zhang
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 7, Iss 1, Pp 1-3 (2022)
Externí odkaz:
https://doaj.org/article/75805ed61f39466baf41743349518a57
Publikováno v:
Organic & Biomolecular Chemistry. 21:2754-2767
We reported the synthesis and anti-RSV or anti-IFV activities of NHC derivatives and 4′-fluorouridine prodrugs, which were evaluated for their chemical stability and PK properties. Tri-isobutyrate ester 1a has potential to be as an antiviral agent.
Autor:
Tianwen Hu, Yuanchao Xie, Fuqiang Zhu, Xudong Gong, Yin Liu, Haitao Xue, Haji A. Aisa, Jingshan Shen
Publikováno v:
Organic Process Research & Development. 26:358-364
Publikováno v:
Chemical Biology & Drug Design. 99:561-572
A series of 2'-deoxy carbocyclic nucleosides characterized by various 6'-substitutions were synthesized and evaluated for their antiviral activities against three viruses, including hepatitis B virus (HBV), hepatitis C virus, and influenza virus. The
Publikováno v:
ACS omega. 7(31)
A three-step sequence for preparing remdesivir, an important anti-SARS-CoV-2 drug, is described. Employing
Autor:
Daibao Wei, Haji Akber Aisa, Wei Zheng, Tianwen Hu, Fuqiang Zhu, Yan Zhang, Guanghui Tian, Yuanchao Xie, Jingshan Shen
Publikováno v:
The Journal of Organic Chemistry. 86:5065-5072
Currently, remdesivir is the first and only FDA-approved antiviral drug for COVID-19 treatment. Adequate supplies of remdesivir are highly warranted to cope with this global public health crisis. Herein, we report a Weinreb amide approach for prepari
Autor:
Tianwen Hu, Bing Huang, Yuanchao Xie, Ma Xiuli, Daibao Wei, Guo Xiaozhen, Jingshan Shen, Jiaqiang Wu
Publikováno v:
Virologica Sinica
Porcine epidemic diarrhea (PED) caused by porcine epidemic diarrhea virus (PEDV) is widespread in the world. In recent years, the increased virulence of the virus due to viral variations, has caused great economic losses to the pig industry in many c