Výsledky vyhledávání - "YuanShan Lai"

Artificial induction of chromosome aneuploidy in CHO cells alters their function as host cells

Autor: Noriko Yamano‐Adachi, Yuto Nakanishi, Wataru Tanaka, YuanShan Lai, Masahiro Yamazaki, Laura Zenner, Hirofumi Hata, Takeshi Omasa

Publikováno v: Biotechnology and Bioengineering. 120:659-673

Chinese hamster ovary (CHO) cells are major host cells for biopharmaceuticals. During culture, the chromosome number of CHO cells alters spontaneously. Here, we investigated the effects of artificial changes in the chromosome number on productivity.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6e6ca3d69487f650c892003f1a4ca18
https://doi.org/10.1002/bit.28289

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Increased antibody productivity in Chinese Hamster Ovary cells through induction of chromosomal instability by cell fusion

Autor: Takeshi Omasa, Masayoshi Onitsuka, YuanShan Lai, Noriko Yamano

Publikováno v: BMC Proceedings

Background Chromosomal instability, which often occurs as a random event in an uncontrollable manner, is a key characteristic of Chinese Hamster Ovary (CHO) cells. This often complicates the process of establishing stable, high antibody-producing CHO

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f672e6265c1966ac571c19f07eee5a2
http://europepmc.org/articles/PMC4685336

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