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Akademický článek

AP-2 Adaptor Complex-Dependent Enhancement of HIV-1 Replication by Nef in the Absence of the Nef/AP-2 Targets SERINC5 and CD4

Autor: Balaji Olety, Yoshiko Usami, Yuanfei Wu, Paul Peters, Heinrich Göttlinger

Publikováno v: mBio, Vol 14, Iss 1 (2023)

ABSTRACT Human immunodeficiency virus type 1 (HIV-1) Nef hijacks the clathrin adaptor complex 2 (AP-2) to downregulate the viral receptor CD4 and the antiviral multipass transmembrane proteins SERINC3 and SERINC5, which inhibit the infectivity of pro

Externí odkaz: https://doaj.org/article/dbaee4229a31442b9b9a70ab90f12c9e

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Akademický článek

Electrochemical Enzyme Sensor Based on the Two-Dimensional Metal–Organic Layers Supported Horseradish Peroxidase

Autor: Yu Xiong, Chao Wang, YuanFei Wu, Chunhua Luo, Dongping Zhan, Shizhen Wang

Publikováno v: Molecules, Vol 27, Iss 23, p 8599 (2022)

Metal–organic frames (MOFs) have recently been used to support redox enzymes for highly sensitive and selective chemical sensors for small biomolecules such as oxygen (O2), hydrogen peroxide (H2O2), etc. However, most MOFs are insulative and their

Externí odkaz: https://doaj.org/article/954a7cbffe8e4176bfe903539131bc17

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Akademický článek

A Long Cytoplasmic Loop Governs the Sensitivity of the Anti-viral Host Protein SERINC5 to HIV-1 Nef

Autor: Weiwei Dai, Yoshiko Usami, Yuanfei Wu, Heinrich Göttlinger

Publikováno v: Cell Reports, Vol 22, Iss 4, Pp 869-875 (2018)

We recently identified the multipass transmembrane protein SERINC5 as an antiviral protein that can potently inhibit HIV-1 infectivity and is counteracted by HIV-1 Nef. We now report that the anti-HIV-1 activity, but not the sensitivity to Nef, is co

Externí odkaz: https://doaj.org/article/74cb79d08819427292dd5e581abef1f5

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Akademický článek

Potent Enhancement of HIV-1 Replication by Nef in the Absence of SERINC3 and SERINC5

Autor: Yuanfei Wu, Balaji Olety, Eric R. Weiss, Elena Popova, Hikaru Yamanaka, Heinrich Göttlinger

Publikováno v: mBio, Vol 10, Iss 3 (2019)

ABSTRACT It has recently emerged that HIV-1 Nef counteracts the antiviral host proteins SERINC3 and SERINC5. In particular, SERINC5 inhibits the infectivity of progeny virions when incorporated. SERINC3 and SERINC5 are also counteracted by the unrela

Externí odkaz: https://doaj.org/article/4570759b8a0d412fab429d4bc1dbaa0d

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Akademický článek

Primate lentiviral Vpx commandeers DDB1 to counteract a macrophage restriction.

Autor: Natalia Sharova, Yuanfei Wu, Xiaonan Zhu, Ruzena Stranska, Rajnish Kaushik, Mark Sharkey, Mario Stevenson

Publikováno v: PLoS Pathogens, Vol 4, Iss 5, p e1000057 (2008)

Primate lentiviruses encode four "accessory proteins" including Vif, Vpu, Nef, and Vpr/Vpx. Vif and Vpu counteract the antiviral effects of cellular restrictions to early and late steps in the viral replication cycle. We present evidence that the Vpx

Externí odkaz: https://doaj.org/article/be7c5f15403341e68930df300688eaa1

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