Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Yuan-Qing Qu"'
Age-related self-DNA accumulation may accelerate arthritis in rats and in human rheumatoid arthritis
Autor:
Wei-Dan Luo, Yu-Ping Wang, Jun Lv, Yong Liu, Yuan-Qing Qu, Xiong-Fei Xu, Li-Jun Yang, Zi-Cong Lin, Lin-Na Wang, Rui-Hong Chen, Jiu-Jie Yang, Ya-Ling Zeng, Rui-Long Zhang, Bai-Xiong Huang, Xiao-Yun Yun, Xuan-Ying Wang, Lin-Lin Song, Jian-Hui Wu, Xing-Xia Wang, Xi Chen, Wei Zhang, Hui-Miao Wang, Li-Qun Qu, Meng-Han Liu, Liang Liu, Betty Yuen Kwan Law, Vincent Kam Wai Wong
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract The incidence of rheumatoid arthritis (RA) is increasing with age. DNA fragments is known to accumulate in certain autoimmune diseases, but the mechanistic relationship among ageing, DNA fragments and RA pathogenesis remain unexplored. Here
Externí odkaz:
https://doaj.org/article/22b49d652b674e008a0d162be949e0a8
Autor:
Yuan-Qing Qu, Lin-Lin Song, Su-Wei Xu, Margaret Sum Yee Yu, Onat Kadioglu, Francesco Michelangeli, Betty Yuen Kwan Law, Thomas Efferth, Christopher Wai-Kei Lam, Vincent Kam Wai Wong
Publikováno v:
Pharmacological Research, Vol 191, Iss , Pp 106769- (2023)
Drug resistance in cancer has been classified as innate resistance or acquired resistance, which were characterized by apoptotic defects and ABC transporters overexpression respectively. Therefore, to preclude or reverse these resistance mechanisms c
Externí odkaz:
https://doaj.org/article/10230bf769b548b5a26383027eeef547
Autor:
Sha-Sha Cheng, Yuan-Qing Qu, Jia Wu, Guan-Jun Yang, Hao Liu, Wanhe Wang, Qi Huang, Feng Chen, Guodong Li, Chun-Yuen Wong, Vincent Kam Wai Wong, Dik-Lung Ma, Chung-Hang Leung
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 12, Iss 3, Pp 1390-1405 (2022)
Cyclin-dependent kinase 9 (CDK9) activity is correlated with worse outcomes of triple-negative breast cancer (TNBC) patients. The heterodimer between CDK9 with cyclin T1 is essential for maintaining the active state of the kinase and targeting this p
Externí odkaz:
https://doaj.org/article/2d4ed931c7e146e492f221e5338d392d
Autor:
Hu-Qiang He, Yuan-Qing Qu, Betty Yuen Kwan Law, Cong-ling Qiu, Yu Han, Ivo Ricardo de Seabra Rodrigues Dias, Yong Liu, Jie Zhang, An-Guo Wu, Cheng-Wen Wu, Simon Wing Fai Mok, Xin Cheng, Yan-Zheng He, Vincent Kam Wai Wong
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
Vascular calcification (VC) in macrovascular and peripheral blood vessels is one of the main factors leading to diabetes mellitus (DM) and death. Apart from the induction of vascular calcification, advanced glycation end products (AGEs) have also bee
Externí odkaz:
https://doaj.org/article/4b7f905b414c44b99a985a416da7afa0
Autor:
Hu-Qiang He, Betty Yuen Kwan Law, Ni Zhang, Cong-ling Qiu, Yuan-Qing Qu, An-Guo Wu, Yu Han, Qi Song, Wen-Lu Zheng, Yong Liu, Yan-Zheng He, Vincent Kam Wai Wong
Publikováno v:
Frontiers in Pharmacology, Vol 10 (2019)
Vascular calcification is a major complication of cardiovascular disease and chronic renal failure. Autophagy help to maintain a stable internal and external environment that is important for modulating arteriosclerosis, but its pathogenic mechanism
Externí odkaz:
https://doaj.org/article/cf0499e2515f42ce8137877d7275d536
Autor:
Lin Lin Song, Yuan Qing Qu, Yong Pei Tang, Xi Chen, Hang Hong Lo, Li Qun Qu, Yun Xiao Yun, Vincent Kam Wai Wong, Rui Long Zhang, Hui Miao Wang, Meng Han Liu, Wei Zhang, Hui Xia Zhang, Joyce Tsz Wai Chan, Cai Ren Wang, Jian Hui Wu, Betty Yuen Kwan Law
Publikováno v:
Redox Biology. 61:102637
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8e1623045a1f1bac5e04b81eb6bd825a
https://doi.org/10.1016/j.redox.2023.102637
https://doi.org/10.1016/j.redox.2023.102637
Autor:
Kai Chang, Chen-Xia Liu, Zi-Yi Zhu, Hong-Xuan Xu, Yan-Yan Wang, Jie Xiong, Yuan-Qing Qu, Zhong-Yong Jiang
Publikováno v:
Medical Journal of Chinese People's Liberation Army, Vol 45, Iss 11, Pp 1131-1137 (2020)
Objective To analyze the genetic and evolutionary properties of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ORF 1ab/S/M proteins and select antigen epitope sequences of mRNA vaccines. Methods We analyzed the worldwide SARS-CoV-2 geno
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doajarticles::2a7f7c2491f6c957aea775975e6828f7
http://plamj.org/index.php/plamj/article/view/2330
http://plamj.org/index.php/plamj/article/view/2330
Autor:
Yuan-Qing Qu, Dik-Lung Ma, Jia Wu, Vincent Kam Wai Wong, Chun-Yuen Wong, Hao Liu, Feng Chen, Qi Huang, Wanhe Wang, Chung-Hang Leung, Sha-Sha Cheng, Guodong Li, Guan-Jun Yang
Publikováno v:
Acta pharmaceutica Sinica. B. 12(3)
Cyclin-dependent kinase 9 (CDK9) activity is correlated with worse outcomes of triple-negative breast cancer (TNBC) patients. The heterodimer between CDK9 with cyclin T1 is essential for maintaining the active state of the kinase and targeting this p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e85037c754f0ebe3e1d3a805c0203da
https://pubmed.ncbi.nlm.nih.gov/35530158
https://pubmed.ncbi.nlm.nih.gov/35530158
Autor:
Liang Liu, Yuesheng Xie, Xi Chen, Francesco Michelangeli, Hui Wang, Wen Jing Yu, Hudan Pan, Zheng Li, Riqiang Luo, Vincent Kam Wai Wong, Wu Zeng, Yuan Qing Qu, Sami Hamdoun, Wei Zhang, Lu Yu, Betty Yuen Kwan Law, Quan Jiang, Congling Qiu, Thomas Efferth, Ni Zhang, Simon Wing Fai Mok, Su-Wei Xu, Yu Han, Tsz Wai Chan, Ivo Ricardo de Seabra Rodrigues Dias
Publikováno v:
British Journal of Pharmacology
Background and purpose Celastrol exhibits anti-arthritic effects in rheumatoid arthritis (RA), but the role of celastrol-mediated Ca2+ mobilization in treatment of RA remains undefined. Here, we describe a regulatory role for celastrol-induced Ca2+ s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2a69050cbd7ebe653e6e42b514e6531
http://europepmc.org/articles/PMC6637043
http://europepmc.org/articles/PMC6637043
Autor:
Betty Yuen Kwan Law, Li-Ping Bai, Vincent Kam Wai Wong, Simon Wing Fai Mok, Xiaobo Zhou, Zhiyuan Zheng, Yuan Qing Qu, Zhi-Hong Jiang
Publikováno v:
Bioorganic Chemistry. 83:450-460
Eleven dauricine derivatives were synthesized and evaluated for their anti-cancer effect in different cancer cells and their autophagic activity in HeLa model cell. Among these newly synthesized compounds, carbamates 2a, 2b, carbonyl ester 3a and sul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d704947ffb2031578ed537dab61ee27
https://doi.org/10.1016/j.bioorg.2018.10.074
https://doi.org/10.1016/j.bioorg.2018.10.074