Zobrazeno 1 - 10
of 64
pro vyhledávání: '"Yuan-Qing Fang"'
Autor:
Matthew G. Beaver, Derek B. Brown, Kiersten Campbell, Yuan-Qing Fang, David D. Ford, Narbe Mardirossian, Kevin D. Nagy, Andreas R. Rötheli, Jillian W. Sheeran, Reem Telmesani, Andrew T. Parsons
Publikováno v:
Organic Process Research & Development. 26:2636-2645
Autor:
Margaret M. Faul, Padmini K. Ananthoji, Athimoolam Arunachalampillai, Matthew G. Beaver, Yuan-Qing Fang, Simon J. Hedley, Brian S. Lucas, Jason S. Tedrow
Publikováno v:
Synthesis.
A chiral Cu(II)-PyBOX complex was prepared and utilized to accomplish desymmetrization of a 1,3-diol en route to AMG 176. An expedient synthesis of the racemic 1,3-diol is described, in addition to efforts for rapid optimization and subsequent kilogr
Autor:
Damith Perera, Neil F. Langille, Simone Spada, Tsang-Lin Hwang, Sheng Cui, Rahul P. Sangodkar, Srividya Sharvan Kumar, Ari Ericson, Kiersten Campbell, Doherty Timothy J, Emiliano Rossi, Jillian W. Sheeran, Gabriella Santoni, John T. Colyer, David D. Ford, Min Liu, Michael A. Lovette, Matthew G. Beaver, Shawn D. Walker, Nancy Jiao, Michal Achmatowicz, Yuan-Qing Fang, Janine K. Tom
Publikováno v:
Organic Process Research & Development. 25:486-499
In this article, we describe the process development efforts to improve the final methylation step in the AMG 397 drug substance process, culminating in the execution of a Good Manufacturing Practi...
Autor:
Anamika Datta, Matthew M. Bio, Changfeng Huang, Scott J. Hecker, Serge H. Boyer, Jillian W. Sheeran, Yuan-Qing Fang, M. Grace Russell, David D. Ford, Kiersten Campbell, Gerald Hummel, Christopher P. Breen
Publikováno v:
Organic Process Research & Development. 25:522-528
We have developed a convenient development-scale reactor (0.44 mol/h) to prepare diazomethane from N-methyl-N-nitroso-p-toluenesulfonamide (MNTS) in ∼80% yield. Diazomethane (CH2N2) made with this ...
Autor:
Adam R. Brown, Rainville Joseph Philip, Joel M. Hawkins, Cheryl Myers Hayward, Ian T. Crouch, Matthew M. Bio, Jean-Nicolas Desrosiers, Sebastien Monfette, Nikita Peperni, Shengquan Duan, Yuan-Qing Fang
Publikováno v:
Organic Process Research & Development. 24:1077-1083
Complex [(DMPU)2Zn(CF2H)2] 1 is a crystalline organometallic reagent with utility in various catalytic difluoromethylation reactions under mild conditions. Unfortunately, this reagent is not commer...
Autor:
Matthew M. Bio, Hui Li, David Kouvchinov, Scott Alan Frank, Martin D. Johnson, Yuan-Qing Fang, Andrew M. Clausen, Mark S. Kerr, Ian T. Crouch, Jillian W. Sheeran
Publikováno v:
The Journal of organic chemistry. 87(4)
The ketone intermediate LSN647712 is a key synthetic intermediate for the drug substance lasmiditan manufacturing process. A three-step connected continuous flow process utilizing a Turbo Grignard reagent, N-methylpiperidin-4-ylmagnesium chloride, an
Autor:
Hui Li, Sheeran, Jillian W., Kouvchinov, David, Clausen, Andrew M., Crouch, Ian T., Bio, Matthew M., Yuan-Qing Fang, Frank, Scott A., Johnson, Martin D., Kerr, Mark S.
Publikováno v:
Journal of Organic Chemistry; 2/18/2022, Vol. 87 Issue 4, p2045-2054, 10p
Autor:
Austin G. Smith, Shawn D. Walker, Tiffany L. Correll, David Yeung, Michael T. Corbett, Brian M. Cochran, John L. Tucker, Matthew M. Bio, Filisaty Vounatsos, Greg Wells, Siân C. Jones, Tawnya G. Flick, Maria Victoria Silva Elipe, Seb Caille, Yuan-Qing Fang
Publikováno v:
The Journal of organic chemistry. 84(8)
A robust process to manufacture AMG 232 was developed to deliver drug substance of high purity. Highlights of the commercial process development efforts include the following: (i) use of a novel bench-stable Vilsmeier reagent, methoxymethylene- N, N-
Autor:
Neil F. Langille, Matthew M. Bio, Helming Tan, Sheng Cui, Matthew G. Beaver, Yuan-Qing Fang, Matthew S. Potter-Racine, Karl B. Hansen
Publikováno v:
Organic Process Research & Development. 20:1341-1346
The development and demonstration of a crystallization-induced dynamic resolution (CIDR) to prepare a chiral diarylmethylamine, a key intermediate toward the synthesis of a potent TRPM8 inhibitor, is described. Essential to the development of this pr
Autor:
Hui, Li, Christopher P, Breen, Hyowon, Seo, Timothy F, Jamison, Yuan-Qing, Fang, Matthew M, Bio
Publikováno v:
Organic Letters
An electrochemically driven, nickel-catalyzed reductive coupling of N-hydroxyphthalimide esters with aryl halides is reported. The reaction proceeds under mild conditions in a divided electrochemical cell and employs a tertiary amine as the reductant