Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Yuan-Hua Ding"'
Autor:
Theresa L. Johnson, Steven Kazmirski, Simon Low, Cyrille Kuhn, Robert V. Stanton, Yuan-Hua Ding, Gayatri D. Deshmukh, Jessie M. English, Haile Tecle, Glen Rennie, Ping Ye, Hu Liu, Joseph Wu, Alan C. Cheng, Suzanne L. Jacques, Rocco Coli, Frederic Feru
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:4885-4891
By targeting an extended region of the conventional 'DFG-out' pocket of p38alpha, while minimizing interactions with the specificity pocket and eliminating interactions with the adenine binding site, we are able to design and synthesize a number of p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84cbf5efbbf3041f28125e01eba59d8c
https://doi.org/10.1016/j.bmcl.2010.06.073
https://doi.org/10.1016/j.bmcl.2010.06.073
Autor:
Darcy Kohls, Simon Low, Glen Rennie, Yuan-Hua Ding, Cyrille Kuhn, Frederic Feru, Michael Kothe, Rocco Coli
Publikováno v:
Chemical Biology & Drug Design. 70:540-546
Polo-like kinase 1 is an important regulator of cell cycle progression whose over-expression is often associated with oncogenesis. Polo-like kinase 1 hence represents an attractive target for cancer intervention. BI 2536 (Boehringer Ingelheim, Ingelh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::70f56f22404ef9e96e6c481d195548de
https://doi.org/10.1111/j.1747-0285.2007.00594.x
https://doi.org/10.1111/j.1747-0285.2007.00594.x
Autor:
Simon Low, Rocco Coli, Yuan-Hua Ding, Alan C. Cheng, Alissa L. Sheils, Cyrille Kuhn, Thomas A. Wynn, Theresa L. Johnson, Jim Nonomiya, Suzanne L. Jacques, Darcy Kohls, Cristina Lewis, Michael Kothe, Kimberly A. Verdries, Christine Loh
Publikováno v:
Biochemistry. 46:5960-5971
Polo-like kinase 1 (Plk1) is an attractive target for the development of anticancer agents due to its importance in regulating cell-cycle progression. Overexpression of Plk1 has been detected in a variety of cancers, and expression levels often corre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5cb7b5150b3f78f35926d557efc4acae
https://doi.org/10.1021/bi602474j
https://doi.org/10.1021/bi602474j
Autor:
Qing Cao, Yuan-Hua Ding, Yan Zhang, Michael Kothe, Tom Ellenberger, Andre Iffland, Simon Low, Darcy Kohls, Ajith V. Kamath, Jing Luan
Publikováno v:
Biochemistry. 44:8312-8325
Phosphodiesterases (PDEs) modulate signaling by cyclic nucleotides in diverse processes such as cardiac contractility, platelet aggregation, lipolysis, glycogenolysis, and smooth muscle contraction. Cyclic guanosine monophosphate (cGMP) stimulated hu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6331c53507f8f9ce83242e98058692f
https://doi.org/10.1021/bi047313h
https://doi.org/10.1021/bi047313h
Autor:
Richard C. Mulligan, Daniel Kalman, Stephen D. Gillies, Kashi Javaherian, Calvin J. Kuo, Susan Park, Junne Kamihara, Rolf Christofferson, Guillermo García-Cardeña, Yuan-Hua Ding, Kin-Ming Lo, Kenneth R. LaMontagne, Brian D. Ackley, Judah Folkman
Publikováno v:
The Journal of Cell Biology
Collagen XVIII (c18) is a triple helical endothelial/epithelial basement membrane protein whose noncollagenous (NC)1 region trimerizes a COOH-terminal endostatin (ES) domain conserved in vertebrates, Caenorhabditis elegans and Drosophila. Here, the c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f470bc4ecc21f8bb4c6b3863a2de6c47
https://doi.org/10.1083/jcb.152.6.1233
https://doi.org/10.1083/jcb.152.6.1233
Autor:
Stefan Hausmann, William E. Biddison, Kathrine J. Smith, Yuan-Hua Ding, David N. Garboczi, Ursula Utz, Don C. Wiley, Kai W. Wucherpfennig
Publikováno v:
The Journal of Immunology. 162:5389-5397
The crystal structures of two human TCRs specific for a HTLV-I Tax peptide bound to HLA-A2 were recently determined, for the first time allowing a functional comparison of TCRs for which the MHC/peptide/TCR structures are known. Extensive amino acid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7d77cd19f9e491febeee628f97dd3ea1
https://doi.org/10.4049/jimmunol.162.9.5389
https://doi.org/10.4049/jimmunol.162.9.5389
Autor:
Rupert Timpl, Robert Shapiro, Kashi Javaherian, Rajiv Chopra, Yuan-Hua Ding, Thomas Boehm, Don C. Wiley, B. A. Harris, Erhard Hohenester, Kin-Ming Lo, Judah Folkman, Julia Lanciotti, Yue Li
Publikováno v:
Proceedings of the National Academy of Sciences. 95:10443-10448
The crystal structure of human endostatin reveals a zinc-binding site. Atomic absorption spectroscopy indicates that zinc is a constituent of both human and murine endostatin in solution. The human endostatin zinc site is formed by three histidines a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3695c4c25282415840a4d19e7672bb4
https://doi.org/10.1073/pnas.95.18.10443
https://doi.org/10.1073/pnas.95.18.10443
Publikováno v:
Biochemistry. 34:14918-14931
The 42 kDa capsid protein of bacteriophage HK97 requires the GroEL and GroES chaperonin proteins of its Escherichia coli host to facilitate correct folding, both in vivo and in vitro. In the absence of GroES and ATP, denatured gp5 forms a stable comp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::312fe99998ab53ff8ae5f0434b8d07db
https://doi.org/10.1021/bi00045a037
https://doi.org/10.1021/bi00045a037
Autor:
Feng Yin, Jing Wang, Yanchao Wang, Jun Xu, Hui Zhang, Xiaoming Zhang, Jianxian Gong, Guimiao Lin, Rongfeng Lan, Fei Lu, Zhen Yang, Yuan-Hua Ding
Publikováno v:
Laboratory investigation; a journal of technical methods and pathology. 92(10)
Polo-like kinase 1 (Plk1) is a mitotic serine/threonine kinase and its kinase activity is closely interrelated to cell cycle progression, various types of cancer development and often correlates with poor prognosis. Thus, it is of prime importance to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48c090141df8f4c81f2a232edb05a54a
https://pubmed.ncbi.nlm.nih.gov/22890557
https://pubmed.ncbi.nlm.nih.gov/22890557
Autor:
Yuan-Hua Ding, Brendan Connolly, Alissa L. Sheils, Michael Kothe, Alan C. Cheng, Ajith V. Kamath, Darcy Kohls, Maura E. Charlton, Laura Weibley, Lily Yang, Qing Cao, Brian J. Stockman
Publikováno v:
Chemical biologydrug design. 73(2)
Aberrant activation of the phosphoinositide 3-kinase pathway because of genetic mutations of essential signalling proteins has been associated with human diseases including cancer and diabetes. The pivotal role of 3-phosphoinositide-dependent kinase-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::902bb0578fd6ff04c7f3b02c2a32a510
https://pubmed.ncbi.nlm.nih.gov/19207420
https://pubmed.ncbi.nlm.nih.gov/19207420