Zobrazeno 1 - 10
of 1 193
pro vyhledávání: '"Yuan Y. Zhao"'
Publikováno v:
Journal of Lipid Research, Vol 57, Iss 4, Pp 597-606 (2016)
Extracellular lysophosphatidate and sphingosine 1-phosphate (S1P) are important bioactive lipids, which signal through G-protein-coupled receptors to stimulate cell growth and survival. The lysophosphatidate and S1P signals are terminated partly by d
Externí odkaz:
https://doaj.org/article/9718ddfde9af41a08611268f696fb056
Publikováno v:
Journal of Lipid Research, Vol 56, Iss 6, Pp 1134-1144 (2015)
Autotaxin (ATX) is a secreted enzyme, which produces extracellular lysophosphatidate (LPA) from lysophosphatidylcholine (LPC). LPA activates six G protein-coupled receptors and this is essential for vasculogenesis during embryonic development. ATX is
Externí odkaz:
https://doaj.org/article/e23ec93fb38a4502832668d128e3f5b4
Autor:
Xiaoyun Tang, Matthew G.K. Benesch, Jay Dewald, Yuan Y. Zhao, Neeraj Patwardhan, Webster L. Santos, Jonathan M. Curtis, Todd P.W. McMullen, David N. Brindley
Publikováno v:
Journal of Lipid Research, Vol 55, Iss 11, Pp 2389-2400 (2014)
Lipid phosphate phosphatase-1 (LPP1) degrades lysophosphatidate (LPA) and attenuates receptor-mediated signaling. LPP1 expression is low in many cancer cells and tumors compared with normal tissues. It was hypothesized from studies with cultured cell
Externí odkaz:
https://doaj.org/article/2d44e8bac66f4097aa70ac4671a8ac9a
Autor:
Yuan Y. Zhao, René L. Jacobs, Danny Galleguillos, Nicholas McCloskey, Susanne Lingrell, Jelske N. van der Veen, Jonathan M. Curtis, Morgan D. Fullerton, Simonetta Sipione, Nicholas D. LeBlond, Dennis E. Vance
Publikováno v:
The FASEB Journal. 33:5045-5057
Phosphatidylethanolamine N-methyltransferase (PEMT) is an important enzyme in hepatic phosphatidylcholine (PC) biosynthesis. Pemt-/- mice fed a high-fat diet are protected from obesity and whole-body insulin resistance. However, Pemt-/- mice develop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40a28bfc1c8f83033aea45149103ae75
https://doi.org/10.1096/fj.201802117r
https://doi.org/10.1096/fj.201802117r
Publikováno v:
Journal of Lipid Research, Vol 57, Iss 4, Pp 597-606 (2016)
Extracellular lysophosphatidate and sphingosine 1-phosphate (S1P) are important bioactive lipids, which signal through G-protein-coupled receptors to stimulate cell growth and survival. The lysophosphatidate and S1P signals are terminated partly by d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::baf8b07408a474ded6babf4e13da4ff6
http://www.sciencedirect.com/science/article/pii/S0022227520354158
http://www.sciencedirect.com/science/article/pii/S0022227520354158
Autor:
Yi M. Ko, Yuan Y. Zhao, Jay Dewald, Ana Lopez-Campistrous, Matthew G.K. Benesch, Xiaoyun Tang, Jonathan M. Curtis, Raymond Lai, Todd P. W. McMullen, David N. Brindley
Publikováno v:
Endocrine-Related Cancer. 22:593-607
Autotaxin is a secreted enzyme that converts extracellular lysophosphatidylcholine to lysophosphatidate (LPA). In cancers, LPA increases tumour growth, metastasis and chemoresistance by activating six G-protein coupled receptors. We examined >200 hum
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46db1137bb00c91eb22535c1d6b1ac1b
https://doi.org/10.1530/erc-15-0045
https://doi.org/10.1530/erc-15-0045
Autor:
David N. Brindley, Todd P. W. McMullen, Jonathan M. Curtis, Matthew G.K. Benesch, Yuan Y. Zhao
Publikováno v:
Journal of Lipid Research, Vol 56, Iss 6, Pp 1134-1144 (2015)
Autotaxin (ATX) is a secreted enzyme, which produces extracellular lysophosphatidate (LPA) from lysophosphatidylcholine (LPC). LPA activates six G protein-coupled receptors and this is essential for vasculogenesis during embryonic development. ATX is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d281e755d593cbfd624424c8910a387c
https://doi.org/10.1194/jlr.m057661
https://doi.org/10.1194/jlr.m057661
Publikováno v:
Molecular Cancer
Background We previously discovered that tetracyclines increase the expression of lipid phosphate phosphatases at the surface of cells. These enzymes degrade circulating lysophosphatidate and therefore doxycycline increases the turnover of plasma lys
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::002a5fc4a0757fe94ca0eed4987634fd
https://doi.org/10.1186/s12943-017-0607-x
https://doi.org/10.1186/s12943-017-0607-x
Autor:
Webster L. Santos, Jay Dewald, Yuan Y. Zhao, Matthew G.K. Benesch, David N. Brindley, Jonathan M. Curtis, Todd P. W. McMullen, Xiaoyun Tang, Neeraj N. Patwardhan
Publikováno v:
Journal of Lipid Research, Vol 55, Iss 11, Pp 2389-2400 (2014)
Lipid phosphate phosphatase-1 (LPP1) degrades lysophosphatidate (LPA) and attenuates receptor-mediated signaling. LPP1 expression is low in many cancer cells and tumors compared with normal tissues. It was hypothesized from studies with cultured cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76a3b5bed3113286dcfe883b08fe3f14
https://pubmed.ncbi.nlm.nih.gov/25271297
https://pubmed.ncbi.nlm.nih.gov/25271297
Autor:
Jay Dewald, Jonathan M. Curtis, Xiaoyun Tang, Todd P. W. McMullen, Akira Ohhata, Bernard P. Kok, Matthew G.K. Benesch, David N. Brindley, Mary M. Hitt, Tatsuo Maeda, Yuan Y. Zhao
Publikováno v:
FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 28(6)
Autotaxin is a secreted enzyme that produces most extracellular lysophosphatidate, which stimulates 6 G-protein-coupled receptors. Lysophosphatidate promotes cancer cell survival, growth, migration, invasion, metastasis, and resistance to chemotherap
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7109b8a915fae1d95afbf35f04b27f5
https://pubmed.ncbi.nlm.nih.gov/24599971
https://pubmed.ncbi.nlm.nih.gov/24599971