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Publikováno v:
Journal of Pineal Research. May2004, Vol. 36 Issue 4, p217-223. 7p. 4 Charts, 2 Graphs.
Publikováno v:
Journal of Neurochemistry. 103:1237-1257
Apolipoprotein E (ApoE), encoded by the apolipoprotein E gene (APOE), plays an important role in the pathogenesis of Alzheimer's disease (AD). The APOE epsilon4 variant is strongly associated with AD. APOE promoter polymorphisms have also been report
Publikováno v:
Current Alzheimer Research. 4:219-228
Alzheimers disease (AD) is currently the most prominent form of dementia among the elderly. Although AD manifests in late adult life, it is not clear when the disease actually starts and how long the neuropathological processes take to develop AD. Th
Autor:
Nigel H. Greig, Jack T. Rogers, Kumar Sambamurti, Debomoy K. Lahiri, Yuan Wen Ge, Bryan Maloney
Publikováno v:
Current Alzheimer Research. 3:475-483
Major hallmarks of Alzheimer's disease (AD) include brain deposition of the amyloid-beta peptide (Abeta), which is proteolytically cleaved from a large Abeta precursor protein (APP) by beta and gamma- secretases. A transmembrane aspartyl protease, be
Autor:
De Moa Chen, Nigel H. Greig, Jason A. Bailey, Arnold Brossi, David Tweedie, Qian Sheng Yu, Debomoy K. Lahiri, Kumar Sambamurti, Mohammad Amjad Kamal, Yuan Wen Ge
Publikováno v:
Journal of Alzheimer's Disease. 10:9-16
Classical hallmarks of Alzheimer's disease (AD) are a synaptic loss, cholinergic neuron death, and abnormal protein deposition, particularly of toxic amyloid-beta peptide (Abeta) that is derived from amyloid-beta protein precursor (AbetaPP) by the ac
Publikováno v:
The FASEB Journal. 19:1-26
Alzheimer's disease is characterized by brain deposition of toxic amyloid beta-peptide (Abeta), generated from the Abeta precursor protein (APP). APP gene expression is regulated via the proximal promoter region (PPR; -46/-1 in the human sequence; +1
Autor:
Hasan K. Siddiqi, Saleh A. Bakheet, Nathalie Benitez, Yuan-Wen Ge, Debomoy K. Lahiri, Nasser H. Zawia, M. Riyaz Basha, Wei Wei
Publikováno v:
The Journal of Neuroscience. 25:823-829
The fetal basis of adult disease (FeBAD) hypothesis states that many adult diseases have a fetal origin. According to FeBAD, injury or environmental influences occurring at critical periods of organ development could result in “programmatic” chan
Publikováno v:
Journal of Pineal Research. 36:224-231
Melatonin levels decrease with aging in mice. Dietary supplementation with melatonin has recently been shown to result in a significant rise in levels of endogenous melatonin in the serum and all other tissue samples tested. Herein, the effects of di
Publikováno v:
Annals of the New York Academy of Sciences. 1010:643-647
Abnormalities in regulation of the beta-amyloid precursor protein (APP) gene might be a crucial factor in Alzheimer's disease (AD). Our aim is to study the role of a specific proximal APP promoter element under the apoptotic condition. Our transfecti