Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Yuan Chao Xue"'
Autor:
Amirhossein Bahreyni, Huitao Liu, Yasir Mohamud, Yuan Chao Xue, Yiyun Michelle Fan, Yizhuo Lyanne Zhang, Honglin Luo
Publikováno v:
BMC Medicine, Vol 21, Iss 1, Pp 1-17 (2023)
Abstract Background Immunotherapy has emerged as an efficient therapeutic approach for cancer management. However, stimulation of host immune system against cancer cells often fails to achieve promising clinical outcomes mainly owing to the immunosup
Externí odkaz:
https://doaj.org/article/d88330b287564f6d9acbca6f49224a99
Autor:
Huitao Liu, Amirhossein Bahreyni, Yasir Mohamud, Yuan Chao Xue, William W.G. Jia, Honglin Luo
Publikováno v:
Molecular Therapy: Oncolytics, Vol 27, Iss , Pp 89-99 (2022)
Genetic modification of coxsackievirus B3 (CVB3) by inserting target sequences (TS) of tumor-suppressive and/or organ-selective microRNAs (miRs) into viral genome can efficiently eliminate viral pathogenesis without significant impacts on its oncolyt
Externí odkaz:
https://doaj.org/article/4a94222077354ffa8c7295b92634621a
Autor:
Yuan Chao Xue, Huitao Liu, Yasir Mohamud, Amirhossein Bahreyni, Jingchun Zhang, Neil R. Cashman, Honglin Luo
Publikováno v:
Journal of Neuroinflammation, Vol 19, Iss 1, Pp 1-15 (2022)
Abstract Background Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease of the motor neuron system associated with both genetic and environmental risk factors. Infection with enteroviruses, including poliovirus and coxsackievirus
Externí odkaz:
https://doaj.org/article/0c9b7a43ad164b81bf0ae6e022e49fb3
Autor:
Hong Yien Tan, Yean Kong Yong, Yuan Chao Xue, Huitao Liu, Tomomi Furihata, Esaki Muthu Shankar, Chen Seng Ng
Publikováno v:
iScience, Vol 25, Iss 6, Pp 104404- (2022)
Summary: Neuroinflammation exacerbates the progression of SOD1-driven amyotrophic lateral sclerosis (ALS), although the underlying mechanisms remain largely unknown. Herein, we demonstrate that misfolded SOD1 (SOD1Mut)-causing ALS results in mitochon
Externí odkaz:
https://doaj.org/article/80e61f00c5c84f00af72f990a561724b
Autor:
Huitao Liu, Yuan Chao Xue, Haoyu Deng, Yasir Mohamud, Chen Seng Ng, Axel Chu, Chinten James Lim, William W. Lockwood, William W.G. Jia, Honglin Luo
Publikováno v:
Molecular Therapy: Oncolytics, Vol 16, Iss , Pp 207-218 (2020)
We recently discovered that coxsackievirus B3 (CVB3) is a potent oncolytic virus against KRAS mutant lung adenocarcinoma. Nevertheless, the evident toxicity restricts the use of wild-type (WT)-CVB3 for cancer therapy. The current study aims to engine
Externí odkaz:
https://doaj.org/article/f7045a01818a4c3ba9b89afc259e27a9
Publikováno v:
Frontiers in Microbiology, Vol 12 (2021)
Enteroviruses (EVs) usurp the host autophagy pathway for pro-viral functions; however, the consequence of EV-induced diversion of autophagy on organelle quality control is poorly defined. Using coxsackievirus B3 (CVB3) as a model EV, we explored the
Externí odkaz:
https://doaj.org/article/594a11ae01674910817575878293b625
Autor:
Yuan Chao Xue, Chen Seng Ng, Pinhao Xiang, Huitao Liu, Kevin Zhang, Yasir Mohamud, Honglin Luo
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 13 (2020)
Genetic analyses of patients with amyotrophic lateral sclerosis (ALS) have revealed a strong association between mutations in genes encoding many RNA-binding proteins (RBPs), including TARDBP, FUS, hnRNPA1, hnRNPA2B1, MATR3, ATXN2, TAF15, TIA-1, and
Externí odkaz:
https://doaj.org/article/df61d1f50e6249dca44b5a88366e17ad
Autor:
Yasir Mohamud, Junyan Shi, Junyan Qu, Tak Poon, Yuan Chao Xue, Haoyu Deng, Jingchun Zhang, Honglin Luo
Publikováno v:
Cell Reports, Vol 22, Iss 12, Pp 3292-3303 (2018)
Summary: Picornaviruses have evolved to hijack host cellular machinery, including the autophagic pathway. However, the mechanisms remain largely unclear. We use coxsackievirus B3 (CVB3) as a model organism to explore the possible role of picornavirus
Externí odkaz:
https://doaj.org/article/651984ea4eed4d1f828ef92f2cc54733
Autor:
Huitao Liu, Yuan Chao Xue, Haoyu Deng, Yasir Mohamud, Chen Seng Ng, Axel Chu, Chinten James Lim, William W. Lockwood, William W.G. Jia, Honglin Luo
Publikováno v:
Molecular Therapy: Oncolytics, Vol 20, Iss , Pp 1-2 (2021)
Externí odkaz:
https://doaj.org/article/786b734c1ed44f258420b22a52fb96bd
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 11 (2018)
Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease that primarily attacks motor neurons in the brain and spinal cord, leading to progressive paralysis and ultimately death. Currently there is no effective therapy. The majo
Externí odkaz:
https://doaj.org/article/cf84df0d81ec475cb67d967865fa46ce