Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Yuan‐Siao Chen"'
Selection of viral capsids and promoters affects the efficacy of rescue of Tmprss3-deficient cochlea
Autor:
Ksenia A. Aaron, Katja Pekrun, Patrick J. Atkinson, Sara E. Billings, Julia M. Abitbol, Ina A. Lee, Yasmin Eltawil, Yuan-Siao Chen, Wuxing Dong, Rick F. Nelson, Mark A. Kay, Alan G. Cheng
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 30, Iss , Pp 413-428 (2023)
Adeno-associated virus (AAV)-mediated gene transfer has shown promise in rescuing mouse models of genetic hearing loss, but how viral capsid and promoter selection affects efficacy is poorly characterized. Here, we tested combinations of AAVs and pro
Externí odkaz:
https://doaj.org/article/12dd1baf9a7e41769ec3b2c66b940104
Autor:
Chung-Fan Hsieh, Jia-Rong Jheng, Guan-Hua Lin, Yu-Li Chen, Jin-Yuan Ho, Chien-Jou Liu, Kuei-Yang Hsu, Yuan-Siao Chen, Yoke Fun Chan, Hui-Ming Yu, Pei-Wen Hsieh, Jyh-Haur Chern, Jim-Tong Horng
Publikováno v:
Emerging Microbes and Infections, Vol 9, Iss 1, Pp 1194-1205 (2020)
ABSTRACTEnterovirus A71 (EV-A71), a positive-stranded RNA virus of the Picornaviridae family, may cause neurological complications or fatality in children. We examined specific factors responsible for this virulence using a chemical genetics approach
Externí odkaz:
https://doaj.org/article/b45d4f4b770747599437838685b96c2c
Autor:
Jia‐Rong Jheng, Yuan‐Siao Chen, Un Iong Ao, Ding‐Cheng Chan, Jenq‐Wen Huang, Kuang‐Yu Hung, Der‐Cheng Tarng, Chih‐Kang Chiang
Publikováno v:
Journal of Cachexia, Sarcopenia and Muscle, Vol 9, Iss 3, Pp 570-584 (2018)
Abstract Background Sarcopenia is the age‐related degeneration characterized with the decline of skeletal muscle mass, strength, and function. The imbalance of protein synthesis and degradation which jeopardizes immune, hormone regulation, and musc
Externí odkaz:
https://doaj.org/article/2cbbbf8034bc40ae9d55edc69335faf0
Autor:
Yuan-Siao Chen, Ernesto Cabrera, Brady J Tucker, Timothy J Shin, Jasmine V Moawad, Douglas J Totten, Kevin T Booth, Rick F Nelson
Publikováno v:
J Med Genet
BackgroundIt is well established that biallelic mutations in transmembrane protease, serine 3 (TMPRSS3) cause hearing loss. Currently, there is controversy regarding the audiological outcomes after cochlear implantation (CI) forTMPRSS3-associated hea
Autor:
Kevin T. Booth, Timothy J. Shin, Rick F. Nelson, Brady J. Tucker, Yuan-Siao Chen, Ernesto Cabrera
OBJECTIVES To review the audiological outcomes after cochlear implantation (CI) for TMPRSS3-associated autosomal recessive non-syndromic hearing loss (ARNSHL) and evaluate the spatial expression pattern of TMPRSS3 within the human cochlea. METHODS Re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1e2c6e7216a4aad83dfdf39d1db0b157
https://doi.org/10.21203/rs.3.rs-632257/v1
https://doi.org/10.21203/rs.3.rs-632257/v1
Autor:
Yuan-Siao Chen, Chung-Fan Hsieh, Yoke Fun Chan, Jyh-Haur Chern, Guan-Hua Lin, Pei-Wen Hsieh, Hui-Ming Yu, Jim-Tong Horng, Chien-Jou Liu, Kuei-Yang Hsu, Jin-Yuan Ho, Yu-Li Chen, Jia-Rong Jheng
Publikováno v:
Emerging Microbes & Infections
article-version (VoR) Version of Record
article-version (VoR) Version of Record
Enterovirus A71 (EV-A71), a positive-stranded RNA virus of the Picornaviridae family, may cause neurological complications or fatality in children. We examined specific factors responsible for this virulence using a chemical genetics approach. Known
Autor:
Kuang Yu Hung, Chih-Kang Chiang, Un Iong Ao, Jia Rong Jheng, Der Cheng Tarng, Ding-Cheng Chan, Jenq-Wen Huang, Yuan Siao Chen
Publikováno v:
Journal of Cachexia, Sarcopenia and Muscle. 9:570-584
Background Sarcopenia is the age-related degeneration characterized with the decline of skeletal muscle mass, strength, and function. The imbalance of protein synthesis and degradation which jeopardizes immune, hormone regulation, and muscle-motor ne
Publikováno v:
Antiviral Research. 188:105019
The proteostasis network guarantees successful protein synthesis, folding, transportation, and degradation. Mounting evidence has revealed that this network maintains proteome integrity and is linked to cellular physiology, pathology, and virus infec
Autor:
Jia-Rong, Jheng, Yuan-Siao, Chen, Un Iong, Ao, Ding-Cheng, Chan, Jenq-Wen, Huang, Kuang-Yu, Hung, Der-Cheng, Tarng, Chih-Kang, Chiang
Publikováno v:
Journal of cachexia, sarcopenia and muscle. 9(3)
Sarcopenia is the age-related degeneration characterized with the decline of skeletal muscle mass, strength, and function. The imbalance of protein synthesis and degradation which jeopardizes immune, hormone regulation, and muscle-motor neuron connec
Publikováno v:
Oncotarget
// Meei-Ling Sheu 1, 2, 3, * , Chin-Chang Shen 4, * , Yuan-Siao Chen 5 , Chih-Kang Chiang 5, 6 1 Department of Medical Research, Taichung Veterans General Hospital, Taichung, Taiwan 2 Institute of Biomedical Sciences, National Chung Hsing University,