Pain hypersensitivity is dependent on autophagy protein Beclin 1 in males but not females

Autor: Theresa H. Tam, Wenbo Zhang, YuShan Tu, Janice L. Hicks, Sophia Farcas, Doyeon Kim, Michael W. Salter

Publikováno v: Cell Reports, Vol 43, Iss 6, Pp 114293- (2024)

Summary: Chronic pain is associated with alterations in fundamental cellular processes. Here, we investigate whether Beclin 1, a protein essential for initiating the cellular process of autophagy, is involved in pain processing and is targetable for

Externí odkaz: https://doaj.org/article/b7003184086941b8b3f90d3cb3df746e

Circulating NOD1 Activators and Hematopoietic NOD1 Contribute to Metabolic Inflammation and Insulin Resistance

Autor: Kenny L. Chan, Theresa H. Tam, Parastoo Boroumand, David Prescott, Sheila R. Costford, Nichole K. Escalante, Noah Fine, YuShan Tu, Susan J. Robertson, Dilshaayee Prabaharan, Zhi Liu, Philip J. Bilan, Michael W. Salter, Michael Glogauer, Stephen E. Girardin, Dana J. Philpott, Amira Klip

Publikováno v: Cell Reports, Vol 18, Iss 10, Pp 2415-2426 (2017)

Insulin resistance is a chronic inflammatory condition accompanying obesity or high fat diets that leads to type 2 diabetes. It is hypothesized that lipids and gut bacterial compounds in particular contribute to metabolic inflammation by activating t

Externí odkaz: https://doaj.org/article/d27abc9d34b1483fb1014debca2d6c7b

Microglia-independent peripheral neuropathic pain in male and female mice

Autor: YuShan Tu, Milind M. Muley, Simon Beggs, Michael W. Salter

Publikováno v: Pain. 163:e1129-e1144

The dominant view in the field of pain is that peripheral neuropathic pain is driven by microglia in the somatosensory processing region of the spinal dorsal horn. Here, to the contrary, we discovered a form of neuropathic pain that is independent of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::855913ccc097a40fc4ae52b73b7d9e04
https://doi.org/10.1097/j.pain.0000000000002643

Microglial P2X4R-evoked pain hypersensitivity is sexually dimorphic in rats

Autor: Katherine Halievski, Josiane C.S. Mapplebeck, Michael W. Salter, Rebecca Dalgarno, Charlie H.T. Kwok, Sofia Assi, Tuan Trang, Jeffrey S. Mogil, YuShan Tu, Orla Moriarty, Simon Beggs

Publikováno v: Pain. 159(9)

Microglia-neuron signalling in the spinal cord is a key mediator of mechanical allodynia caused by peripheral nerve injury. We recently reported sex differences in microglia in pain signalling in mice: spinal mechanisms underlying nerve injury-induce

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18c5214fd08bf2bd964df8ebbbc2d86e
https://pubmed.ncbi.nlm.nih.gov/29927790

Canadian Spine Society01.1.1: Surgery versus standardized nonoperative care for the treatment of lumbar disc herniations: a Canadian trial02.1.1: Wait times for elective spine surgery across Canada: data from the Canadian Spine Outcomes and Research Network03.1.1: Presurgical physician utilization in elective thoracolumbar spine surgery candidates: a nationwide analysis from the CSORN database04.1.2: Activities performed and treatments conducted prior to consultation with a spine surgeon: Are patients and clinicians following evidence-based clinical practice guidelines?05.1.2: Patient-reported disability versus objective physical performance measures in assessing patient recovery06.1.2: Risk factors for work status in low back pain patients: a cross-sectional analysis of patients presenting to the Ontario Inter-professional Spine Assessment and Education Clinics07.1.3: Comparison of symptomatic, functional and demographic characteristics of postsurgical versus nonoperative LBP patients08.1.3: Are primary care patients with different patterns of low back pain epidemiologically distinct?09.1.3: Lack of prognostic model validation in low back pain prediction studies10.1.4: Larger scoliosis curve magnitude is associated with increased surgical and perioperative complications: a multi-centre analysis of 1173 adolescent idiopathic scoliosis curves11.1.4: Superior extension of upper instrumented level in distraction-based surgery: a surrogate for clinically significant PJK12.1.4: The optimal surgical approach for Lenke 5 curves: Is the anterior approach ready for a comeback?13.1.5: Improving quality and safety in pediatric spine surgery: the team approach14.1.5: Posterior vertebral column resection in pediatric deformity: the advantages of staging15.1.5: Minimally invasive surgery in adolescent idiopathic scoliosis: lessons learned at mean 2-year follow-up16.2.1: Development of a Canadian competency-based spine surgery fellowship education curriculum17.2.1: Computer-assisted surgery is an effective educational tool for the training of orthopedic surgery residents in pedicle screw placement18.2.1: Validation of the Calgary Spine Severity Score19.2.2: Can triaging referrals with a simple 3-item pain questionnaire reduce wait times for consultations for patients who would benefit from lumbar spinal surgery?20.2.2: Strategies to improve the credibility of meta-analyses in spine surgery: a systematic survey21.2.2: The societal cost of waiting to see a spine surgeon for lower back symptoms in Canada22.2.3: The cost of an adverse event depends on its definition and method of capture23.2.3: Economic evaluation of intraoperative cone beam CT-based navigation for the placement of spinal pedicle screws: a patient-level cost-effectiveness analysis24.2.3: Predictors of inappropriate emergency department utilization following elective thoracolumbar spine surgery25.2.4: Incidence, impact and risk factors of adverse events in thoracic and lumbar spine fractures. An ambispective cohort analysis of 390 patients26.2.4: Factors associated with adverse events in major elective spine, knee, and hip in-patient orthopedic surgery27.2.4: Prognostic factors for survival in surgical series of symptomatic metastatic epidural spinal cord compression: a prospective North American multicentre study in 142 patients28.2.5: A comparison of 2 prospective adverse event recording tools with institutional ICD-10 coding for detecting perioperative adverse events in patients undergoing spinal surgery29.2.5: Assessment of impact of long-cassette standing radiographs on surgical planning for lumbar pathology: an international survey of spine surgeons30.2.5: Long-term patient-reported outcome and surgical survivorship of MIS fusion for low-grade spondylolisthesis31.3.1: The effect of prolonged postoperative antibiotic administration on the rate of infection in patients undergoing posterior spine surgery requiring a Hemovac drain32.3.1: Preliminary results of a Phase 1 trial on the use of photodynamic therapy in vertebral metastases33.3.1: The minimal clinically important difference of the modified Japanese Orthopaedic Association score in patients with degenerative cervical myelopathy undergoing surgical intervention34.3.1: Patient and surgeon radiation exposure during spinal instrumentation using intraoperative CT-based navigation35.3.2: Are postoperative pelvic parameters and sagittal balance predictive of further lumbar surgery in patients with spinal stenosis?36.3.2: Postoperative ambulation in patients undergoing total hip arthroplasty, total knee arthroplasty and elective lumbar spine surgery to treat arthritic pathologies37.3.2 Pain on the brain: Is the SF-36 mental component summary enough?38.3.2: Accurate and safe cervical osteotomy for kyphotic deformity in ankylosing spondylitis39.3.3: Adjacent segment pathology in the lumbar spine: progressive disease or a consequence of iatrogenic fusion?40.3.3: The association of cervical spine alignment with neurological recovery in a prospective cohort of surgical myelopathy patients: analysis of a series of 124 cases41.3.3: Use of neuropathic pain questionnaires in predicting the development of failed back surgery syndrome following lumbar discectomy for radiculopathy42.3.3: Quality of life and neurological outcomes after surgical decompression in patients with cervical ossification of the posterior longitudinal ligament: prospective, multicentre AOSpine International study of 479 patients43.3.4: Minimally invasive decompression in focal lumbar spinal stenosis with or without stable spondylolisthesis — comparative outcomes and reoperation rates at a minimum of 2 years44.3.4: Impact of nonoperative care utilization on postthoracolumbar spine surgery outcomes: a national perspective using the CSORN registry45.3.4: Presurgical imaging, testing and injection utilization in elective thoracolumbar spine surgery candidates: a nationwide analysis from the CSORN database46.3.5: A clinical prediction rule for clinical outcomes in patients undergoing surgery for degenerative cervical myelopathy: analysis of an international AOSpine prospective multi-centre dataset of 743 patients47.3.5: A comparison of health-related quality of life outcomes in spinal cord injury patients residing in rural and urban areas48.3.5: Minimally invasive versus open discectomy: a systematic review and meta-analysis49.1.1: Validity of transcranial motor evoked potentials as early indicators of neural compromise in rat model of spinal cord compression50.1.2: Validation of true spine length radiographic measurements51.1.3: Closure of the intervertebral disc annulus fibrosus using a novel suture application device — in vivo porcine and ex vivo biomechanical evaluation52.1.4: Vertebroplasty versus kyphoplasty in osteoporotic vertebral compression fracture model: What is safer?53.1.5: Brain-derived neurotrophic factor promotes intraneural macrophage migration and allodynia in experimental disc-herniation neuropathy54.1.6: Development and evaluation of an open-source 3D virtual simulator with integrated motion-tracking as a teaching tool for pedicle screw insertion55.2.7: Preoperative 'amber flag' psychological measure scores and patient expectations: a nationwide analysis from the CSORN database56.2.8: Assessment of frailty in elderly spinal surgery patients57.2.9: Predicting adverse events and their impact on hospital length of stay in a prospective Spine AdVerse Events Severity (SAVES) database58.2.10: Clinical and surgical predictors of perioperative complications in patients with degenerative cervical myelopathy: results from the multicentre, prospective AOSpine International study on 479 patients59.2.11: Longitudinal analysis of the incidence of adverse events in tertiary spine referral centres: a national perspective from the Canadian Spine Outcomes and Research Network (CSORN) registry60.2.12: The use of validated clinical outcome measures in spinal surgery: an analysis of recent annual meeting abstracts61.1.13: The efficacy and accuracy of cone beam CT (O-Arm) navigation (StealthStation) on screw position in primary cases of adult major deformity surgery62.1.14: Does early surgical decompression improve neurological recovery of complete spinal cord injury? A prospective cohort study63.1.15: The role of MRI in predicting surgical outcome in patients with degenerative cervical myelopathy64.1.16: Postsurgical patients can have similar functional improvements and return to work rates following rehabilitation as those treated nonsurgically65.1.17: Intraoperative cone beam CT (O-Arm) and stereotactic navigation (StealthStation) system in complex adult spine surgery — early experience and learning curve66.1.18: A pilot randomized controlled trial of iodine-impregnated plastic adhesive drape usage in spine surgery and the effect on wound bacterial load67.2.19: Dynesys long-term outcome study68.2.20: Maverick total disc replacement in a real-world patient population: a prospective, multicentre observational study69.2.21: Pedicle screw malposition in revision spinal surgery: efficacy of intraoperative CT-based navigation70.2.22: Intraoperative skull-femoral traction in posterior spinal arthrodesis for adolescent idiopathic scoliosis: the impact on perioperative outcomes and health resource utilization71.2.23: The effect of growth-friendly surgery on coronal and sagittal plane spine growth in idiopathic scoliosis72.2.24: A qualitative web-based expert opinion analysis on the adoption of intraoperative CT and navigation systems in spine surgery

Autor: Melissa Nadeau, Chukwudi Chukwunyerenwa, David Parsons, Harvey Wu, Peter Jarzem, Godefroy Hardy-St-Pierre, Philippe Phan, Ana Contreras, Greg McIntosh, Aria Nouri, Etienne Bourassa-Moreau, John Street, Michael Johnson, Lindsay Tetreault, Tamir Ailon, Rachelle Palkovsky, Neil Manson, Stewart McLachlin, Mohammed Shamji, Fahad Abduljabbar, Antony Bateman, Alan Spurway, Susan Morris, Nathan Evaniew, R. Andrew Glennie, B. Roy Chaudhary, Hiroaki Nakashima, Andrew Jack, Jacques Bouchard, Erin Bigney, Michael Cochran, Joel Phillips, Albert Yee, Darryl Collings, Simon Harris, Dominic Maggio, Christopher Witiw, Anick Nater, Dov B. Millstone, Meghan Flood, Nicolas Dea, Clifford Lin, Ghazal Fazli, Darren Roffey, Ahmed Aoude, Jeremie Larouche, Firoz Miyanji, Nadim Joukhadar, Lauren DellaMora, Melissa McKeon, Elliot Layne, Alexandra Stratton, Chris Bailey, Stewart Bailey, Patricia Rosas-Arellano, Shauna Dehens, Keith Sequeira, Tom Miller, Jim Watson, Fawaz Siddiqi, Kevin Gurr, Jennifer Urquhart, Ken Thomas, Lauren Hirsch, Edward Abraham, Alana Green, Courtney Wilson, Stephen Kingwell, Eugene Wai, Emily Taylor, Joshua Murray, Wayne Albert, Raja Rampersaud, Hamilton Hall, Tom Carter, Chris Gregg, Anthony V. Perruccio, Elizabeth M. Badley, Y. Raja Rampersaud, Ivan Steenstra, Tracey Bastrom, Amer Samdani, Burt Yaszay, David Clements, Suken Shah, Michelle Marks, Randal Betz, Harry Shufflebarger, Peter Newton, David Skaggs, John Heflin, Mohamad Yasin, Ron El-Hawary, Jahangir Asghar, Christopher Reilly, John Choi, Janice Mok, Michael Nitikman, Sameer Desai, Siddesh Doddabasappa, Scott Paquette, Charles Fisher, Ian Domisse, Veronica Wadey, Joel Finkelstein, John Hurlbert, Robert Broad, Richard Fox, Doug Hedden, Andrew Nataraj, Tim Carey, Michael Chapman, Paul Moroz, Don Chow, Eva Tsai, Sean Christie, Kris Lundine, Jacques Paquet, Jan Splawinski, Brian Wheelock, Michael Goytan, Henry Ahn, Eric Massicotte, Michael Fehlings, Hamzah Alhamzah, Maryse Fortin, Jean Ouellet, Michael Weber, Ken C. Thomas, Matt Coyle, Leon van der Watt, Mohit Bhandari, Michelle Ghert, Ilyas Aleem, Brian Drew, Gordon Guyatt, Jeyagobi Jeyaratnam, Nadia Nandlall, Peter Coyte, Kala Sundararajan, Juliet Batke, Nic Dea, Branko Kopjar, Alexander Vaccaro, Paul Arnold, James Schuster, Laurence Rhines, Mark Dekutoski, Ziya Gokaslan, John France, Peter Rose, Justin Smith, Christopher Shaffrey, Virginie Lafage, Frank Schwab, Regis Haid, Themi Protopsaltis, Eric Klineberg, Justin Scheer, Shay Bess, Jens Chapman, Christopher Ames, Lori Nutt, Linda Kuska, Shane Burch, Arjun Sahgal, Edward Chow, Carolyn Niu, Carl Fisher, Cari Whyne, Margarete Akens, Stuart Bisland, Brian Wilson, Pierre Cote, Daniel Mendelsohn, Jason Strelzow, Marcel Dvorak, Corinne Tallon, Neil A. Manson, Alana J. Green, Edward P. Abraham, Ken Mogadham, Ganesh Swamy, Antonio Tsahtsarlis, Mashfiqul Siddiqui, Godefroy Hardy-St. Pierre, Chandan Mohanty, Alina Shcharinsky, Narihito Nagoshi, Nouri Aria, Rohit Amritanand, Steven Passmore, Vanessa Noonan, Moin Khan, Desmond Kwok, Jason Howard, Douglas Rasmusson, Waleed Kishta, Christian Balkovec, Robert Harrison, Stuart McGill, Abdulaziz Al-Jurayyan, Saad Alqahtani, Zeeshan Sardar, Rajeet Singh Saluja, Thomas Steffen, Lorne Beckman, YuShan Tu, Michael Salter, Brendan Polley, Mirza Beig, Fred Nicholls, Peter Wagner, Hanbing Zhou, Natalie Egge, Maribeth Harrigan, Anthony Lapinsky, Patrick Connoly, Christian DiPaola, Gamaliel Tan, Isaac Ryan Perlus, Jim Kennedy, Brian Lenehan, Danny Mendelsohn, Jean-Marc Mac-Thiong, Stefan Parent, Ang Li, Cynthia Thompson, Juan Zamorano, Kristian Dalzell, Aileen Davis, David Mikulis, Marcel F.S. Dvorak, Charles G. Fisher, Vu (Brian) Le, Paul MacPherson, Marc Desjardins, Ronald L. Henderson, Leonardo Simoes, Richard Assaker, Karsten Ritter-Lang, Dominique Vardon, Stephane Litrico, Stephane Fuentes, Michael Putzier, Jorg Frank, Pierre Guigui, Gerard Nakach, Jean-Charles Le Huec, Andrew Pennington, Kaiyun Yang, Rachael Da Cunha, Samir Al Sayegh, Jeremy LaMothe, Michael Letal, Herman Johal, Fabio Ferri-de-Barros, Luke Gauthier, Charlie Johnston, Anna McClung, Helen Novak Lauscher, Charles Fischer

Publikováno v: Canadian Journal of Surgery. 58:S43-S70

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::00dd26a584d8657a0705b8b8b6797d80
https://doi.org/10.1503/cjs.005515