Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Yu. V. Ostapiuk"'
Publikováno v:
Біологічні студії, Vol 16, Iss 4, Pp 19-32 (2022)
Background. Drug delivery systems (DDS) have demonstrated a significant ability to overcome many of the challenges associated with the delivery of hydrophobic chemotherapeutic compounds to tumor tissues. However, hepatotoxicity and suppression of the
Externí odkaz:
https://doaj.org/article/82f707fcfcde49b1a1370aea6bb87fbf
Autor:
N. S. Finiuk, O. Yu. Klyuchivska, I. I. Ivasechko, N. E. Mitina, Yu. V. Ostapiuk, M. D. Obushak, O. S. Zaichenko, A. M. Babsky, R. S. Stoika
Publikováno v:
The Ukrainian Biochemical Journal, Vol 93, Iss 3, Pp 39-51 (2021)
Thiazole derivatives are perspective antitumor compounds characterized by a broad range of bioactivity, while polymeric carriers are widely used to enhance the efficiency of biological action of drugs, improve their biocompatibility and water solubil
Externí odkaz:
https://doaj.org/article/ec798388f6fa40e09972e029bd7eb46e
Autor:
V. P. Hreniukh, N. S. Finiuk, Ya. R. Shalai, B. O. Manko, B. V. Manko, Yu. V. Ostapiuk, O. R. Kulachkovskyy, M. D. Obushak, R. S. Stoika, A. M. Babsky
Publikováno v:
The Ukrainian Biochemical Journal, Vol 92, Iss 2, Pp 121-130 (2020)
Thiazole derivatives have cytotoxic effects towards tumor cells, such as glioblastoma, melanoma, leukemia and lymphoma. However, the intracellular mechanism of this action is not clear. The aim of our study was to investigate the action of N-(5-benzy
Externí odkaz:
https://doaj.org/article/0d95acffb7b64a4e9267c50ffed7c816
Autor:
N. S. Finiuk, I. I. Ivasechko, O. Yu. Klyuchivska, Yu. V. Ostapiuk, V. P. Hreniukh, Ya. R. Shalai, V. S. Matiychuk, M. D. Obushak, A. M. Babsky, R. S. Stoika
Publikováno v:
The Ukrainian Biochemical Journal, Vol 91, Iss 2, Pp 29-39 (2019)
Derivatives of 2-amino-5-benzylthiazole are heterocyclic pharmacophores that exhibit different pharmacological activities including anticancer action. The mechanisms of such action of these compounds are not clear. The aim of the present study was to
Externí odkaz:
https://doaj.org/article/27ac830802be498180465ac22808e03e
Autor:
N. S. Finiuk, V. P. Hreniukh, Yu. V. Ostapiuk, V. S. Matiychuk, M. D. Obushak, R. S. Stoika, A. M. Babsky
Publikováno v:
Біологічні студії, Vol 12, Iss 2, Pp 25-34 (2018)
We have found that new derivatives of 2-amino-5-benzylthiazole possess cytotoxic action towards human tumor cells (Finiuk et al., Biopolym. Cell, 2017; Finiuk et al., Ukr. Biochem. J., 2018). A release of the chemotherapeutic drugs into the environme
Externí odkaz:
https://doaj.org/article/c8b6405b53a641a1a8c46635654e359b
Autor:
N. S. Finiuk, Yu. V. Ostapiuk, V. P. Hreniukh, Ya. R. Shalai, V. S. Matiychuk, M. D. Obushak, R.S. Stoika, A. M. Babsky
Publikováno v:
The Ukrainian Biochemical Journal, Vol 90, Iss 2, Pp 25-32 (2018)
The research aim was to test cytotoxic effects in vitro of seven novel pyrazolothiazolopyrimidine derivatives in targeting several lines of tumor and pseudo-normal mammalian cells. We demonstrated that cytotoxic effects of these derivatives depended
Externí odkaz:
https://doaj.org/article/1a4cae2bcb594d4fa9447dd12781bbc6
Autor:
M. V. Ilkiv, Ya. R. Shalai, B. O. Manko, Yu. V. Ostapiuk, N. E. Mitina, A. S. Zaichenko, A. M. Babsky
Publikováno v:
Biopolymers and Cell. 38:158-168
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ebc47954e21bec3043f307022e06b364
https://doi.org/10.7124/bc.000a7d
https://doi.org/10.7124/bc.000a7d
Autor:
Nataliya Mitina, O. S. Zaichenko, Mykola D. Obushak, Yu. V. Ostapiuk, O. Yu. Klyuchivska, Andriy M. Babsky, Rostyslav Stoika, I. I. Ivasechko, N. S. Finiuk
Publikováno v:
Ukrainian Biochemical Journal, Vol 93, Iss 3, Pp 39-51 (2021)
Thiazole derivatives are perspective antitumor compounds characterized by a broad range of bioactivity, while polymeric carriers are widely used to enhance the efficiency of biological action of drugs, improve their biocompatibility and water solubil
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b9231d6e7bf9869757430d5b1623a51
https://doi.org/10.15407/ubj93.02.039
https://doi.org/10.15407/ubj93.02.039
Autor:
Andriy M. Babsky, Yu. V. Ostapiuk, Rostyslav Stoika, Mykola D. Obushak, V. P. Hreniukh, Vasyl S. Matiychuk, N. S. Finiuk
Publikováno v:
Біологічні студії, Vol 12, Iss 2, Pp 25-34 (2018)
We have found that new derivatives of 2-amino-5-benzylthiazole possess cytotoxic action towards human tumor cells (Finiuk et al., Biopolym. Cell, 2017; Finiuk et al., Ukr. Biochem. J., 2018). A release of the chemotherapeutic drugs into the environme
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75d2d76024b9ae48d8bfaaa03c5afb00
http://publications.lnu.edu.ua/journals/index.php/biology/article/view/818
http://publications.lnu.edu.ua/journals/index.php/biology/article/view/818
Publikováno v:
Biopolymers and Cell. 34:59-71
Aim. Synthesis of series of new N-(5-benzyl-thiazol-2-yl)-2-(heteryl-5-ylsulfanyl)-acetamides and study on their anticancer activity. Methods. Organic synthesis, analytical and spectral meth-ods, pharmacological screening. Results. [2-chloro-N-(5-ary
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc207da60b47a373eeb60e0472e59fc7
https://doi.org/10.7124/bc.000971
https://doi.org/10.7124/bc.000971