Výsledky vyhledávání - "Yu. N. Bulychev"

Synthesis and biological activity of isoalantolactone—tryptamine conjugates

Autor: Yu. N. Bulychev, S. V. Afanas’eva, Sergey G. Klochkov, Elena F. Shevtsova, Margarita E. Neganova

Publikováno v: Russian Chemical Bulletin. 61:409-415

Previously unknown adducts of substituted tryptamines with sesquiterpene lactones, viz., isoalantolactone and its epoxy derivative, were synthesized by the Michael reaction. The compounds obtained were tested for various types of biological activity.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::092ccd87796889f8236dd7952487ac0a
https://doi.org/10.1007/s11172-012-0058-x

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The intelligent analysis of the cytotoxic activity of a chemical compound using the strategies of the JSM method

Autor: V. G. Blinova, D. A. Dobrynin, V. V. Reshetnikova, Yu. N. Bulychev

Publikováno v: Automatic Documentation and Mathematical Linguistics. 44:151-163

The intelligent analysis of the cytotoxic activities of trifluoro-substituted pyrazolo(1,5-a)pyrimidines was carried out using the strategies of the JSM method, viz., induction, analogy, and abduction. The cytotoxic activity of the compounds relating

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ef5bb40dec05b8237c81acb99b3bd0c0
https://doi.org/10.3103/s0005105510030076

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Three-component condensation of trifluoromethyl-substituted cyanovinylphosphonates, arylamines, and ketones and cytotoxic activity of products thus obtained

Autor: A. F. Shidlovskii, N. D. Chkanikov, Boris B. Averkiev, M. Yu. Antipin, Yu. N. Bulychev, Alexander S. Peregudov

Publikováno v: Russian Chemical Bulletin. 59:144-161

A three-component condensation of trifluoromethyl-substituted cyanovinylphosphonates, arylamines, and ketones (acetone, cyclopentanone, or cyclohexanone) has been studied. A possibility of using trifluoromethyl-substituted cyanovinylphosphonates as p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8e95f3f1b9096d6eb590af2b7cf6f26b
https://doi.org/10.1007/s11172-010-0057-8

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Synthesis and cytotoxic activity of heterocyclization products of 1,1-dicyano-2-hetaryl-2-trifluoromethylethylenes

Autor: Alexander S. Peregudov, Yu. N. Bulychev, N. D. Chkanikov, A. F. Shidlovskii, Yu. E. Pavlova, D. B. Gusev

Publikováno v: Russian Chemical Bulletin. 59:162-176

Methods for the synthesis of novel fluorinated compounds by reaction of 1,1-dicyano-2-hetaryl-2-trifluoromethylethylenes with a variety of nitrogen heterocycles have been developed. Cyctotoxicity of the obtained organofluorine heterocycles were studi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::88f749780b00b239c5a84859b6bedec0
https://doi.org/10.1007/s11172-010-0058-7

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Synthesis and cytotoxic activity of α-santonin amino-derivatives

Autor: G. K. Gerasimova, Sergey G. Klochkov, S. V. Afanas’eva, Yu. N. Bulychev, A. N. Pushin, N. K. Vlasenkova

Publikováno v: Chemistry of Natural Compounds. 45:817-823

Previously unknown amino-derivatives of the natural sesquiterpene lactone α-santonin were synthesized. The activity of the products against several human tumor-cell lines was studied.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e90a4b851031a6bc81ecfd108a0d1393
https://doi.org/10.1007/s10600-010-9499-3

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Synthesis and cytotoxic activity of the products of heterocyclization of trifluoromethylcyanovinyl phosphonates

Autor: N. D. Chkanikov, Yu. N. Bulychev, Alexander S. Peregudov, A. F. Shidlovskii

Publikováno v: Pharmaceutical Chemistry Journal. 43:549-559

Heterocyclization reactions of trifluoromethylcyanovinyl phosphonates (TFMCPs) with aminopyrazoles, aminopyridines, amidines, and arylhydrazines have been studied. It is shown that TFMCPs can be used as precursors of 4,5-dihydropyrazolo[1,5-a]pyrimid

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::99042beacb4cc66b321cd005316c267c
https://doi.org/10.1007/s11094-010-0349-1

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Synthesis and cytotoxic activity of trinitromethyl derivatives of 1,3,5-triazine

Autor: A. A. Gidaspov, V. V. Bakharev, Yu. N. Bulychev, N. G. Yakunina

Publikováno v: Pharmaceutical Chemistry Journal. 42:241-244

New trinitromethyl derivatives of 1,3,5-triazine were synthesized with different substituents in positions 2 and 4. Data on the in vitro cytotoxic activity of the resulting compounds were obtained using a panel of 60 human tumor cell lines. The most

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::360493ca146266de9b64ac0e1f5acdff
https://doi.org/10.1007/s11094-008-0101-2

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