Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Yu-zhou Gui"'
Autor:
Yu-zhou Gui, Wei Wang, Qing-qing Wu, Qi-chen Ding, Hong-jie Qian, Qiu-bei Lu, Ying-jun Zhang, Yu-lei Zhuang, Li Deng, Ying-lin Zuo, Lin Luo, Jing-ying Jia
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Heart failure is the most costly cardiovascular disorder. New treatments are urgently needed. This study aims to evaluate the safety, pharmacokinetics, and pharmacodynamic profile of HEC95468, a soluble guanylate cyclase (sGC) stimulator, in healthy
Externí odkaz:
https://doaj.org/article/471eb2450690481191e91200a2f0c4db
Autor:
Yi Fang, Jing-Xin Li, Davone Duangdany, Yang Li, Xi-Lin Guo, Chanthala Phamisith, Bo Yu, Ming-Yun Shen, Bin Luo, Yu-Zhu Wang, Si-Jun Liu, Fan-Fan Zhao, Cong-Cong Xu, Xu-Hui Qiu, Rong Yan, Yu-Zhou Gui, Rong-Juan Pei, Jie Wang, Haifa Shen, Wu-Xiang Guan, Hang-Wen Li, Mayfong Mayxay
Publikováno v:
EClinicalMedicine, Vol 67, Iss , Pp 102372- (2024)
Summary: Background: The mRNA vaccine has demonstrated significant effectiveness in protecting against SARS-CoV-2 during the pandemic, including against severe forms of the disease caused by emerging variants. In this study, we examined safety, immun
Externí odkaz:
https://doaj.org/article/b49863887c81437fa479a9b75dda6a56
Autor:
Yu-Zhou Gui, Xue-Ning Li, Jing-Xin Li, Ming-Yun Shen, Mei-Wei Zhang, Ye Cao, Hong-Rong Xu, Hui Li, Jie Cheng, Liang Pan, Ying-Lei Yi, Li-Yu Liang, Cheng-Yin Yu, Gang-Yi Liu, Chen Yu, Bi-Jie Hu, Feng-Cai Zhu, Fei Liang, Haifa Shen, Jing-Ying Jia, Hang-Wen Li, Jian Zhou, Jia Fan
Publikováno v:
EBioMedicine, Vol 91, Iss , Pp 104586- (2023)
Summary: Background: We assessed the safety and immunogenicity of a core–shell structured lipopolyplex (LPP) based COVID-19 mRNA vaccine, SW-BIC-213, as a heterologous booster in healthy adults. Methods: We conducted an open-labeled, two-centered,
Externí odkaz:
https://doaj.org/article/8a8a7fea066c4164a25277ccaada978c
Autor:
Wen-yu Wu, Hong Yan, Xin-bo Wang, Yu-zhou Gui, Fei Gao, Xi-lan Tang, Yin-lin Qin, Mei Su, Tao Chen, Yi-ping Wang
Publikováno v:
PLoS ONE, Vol 9, Iss 4, p e94957 (2014)
The proliferation of vascular smooth muscle cells may perform a crucial role in the pathogenesis of diabetic vascular disease. AMPK additionally exerts several salutary effects on vascular function and improves vascular abnormalities. The current stu
Externí odkaz:
https://doaj.org/article/2ed24a28fce1430b87db6db452c9c0b1
Autor:
Chengyin Yu, Liang Hu, Hui-hui Li, Cong Xi, Fei Gao, Sheng Yao, Yiping Wang, Yu-zhou Gui, Hong Yan, Ye Yang
Publikováno v:
Cardiovascular Research. 112:502-514
Aims Atherosclerosis is the most common cause of cardiovascular diseases, such as myocardial infarction and stroke. We hypothesized that nagilactone B (NLB), a small molecule extracted from the root bark of Podocarpus nagi (Podocarpaceae), suppresses
Publikováno v:
Acta Pharmacologica Sinica. 37:1337-1348
Betulin is a pentacyclic triterpenoid isolated from the bark of yellow and white birch trees with anti-cancer and anti-malaria activities. In this study we examined the effects of betulin on atherosclerosis in apoE−/− mice and the underlying mech
Autor:
Meng-qi Zhang, Yun Liu, Chen Yu, Shuijun Li, Yu-zhou Gui, Wei Wang, Chuan Lu, Hongcao Zheng, Youli Lu, Gangyi Liu, Yiping Wang, Jingying Jia
Publikováno v:
Biomedical Chromatography. 30:1291-1296
Sulcardine sulfate (Sul), a novel antiarrhythmic agent, is currently in phase I and phase II clinical trials. To elucidate its clinical pharmacokinetic characteristics, a rapid and accurate liquid chromatography-tandem mass spectrometry (LC-MS/MS) me
Autor:
Chen Yu, Yu-zhou Gui, Xiaopei Lu, Weiwei Shen, Chunxia Dong, Qinyi Zhou, Gangyi Liu, Meng-qi Zhang
Publikováno v:
Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 6, Iss 1, Pp 55-63 (2016)
Acta Pharmaceutica Sinica B, Vol 6, Iss 1, Pp 55-63 (2016)
A quantitative method for clopidogrel using online-SPE tandem LC–MS/MS was developed and fully validated according to the well-established FDA guidelines. The method achieves adequate sensitivity for pharmacokinetic studies, with lower limit of qua
Autor:
Cheng-yin Yu, Chen Yu, Gangyi Liu, Yu-zhou Gui, Hongchao Zheng, Darek Gorecki, Xiao-hui Liu, Yiping Wang, Asmita V. Patel, Hai-ming Liu
Publikováno v:
Yu, C, Liu, G, Liu, X, Gui, Y, Liu, H, Zheng, H, Gorecki, D, Patel, A V, Yu, C & Wang, Y 2018, ' Proteomics analysis reveals a potential new target protein for lipid-lowering effect of Berberine8998 ', Acta Pharmacologica Sinica, vol. 39, pp. 1473-1482 . https://doi.org/10.1038/aps.2017.200
Aims - The objective of this study was to investigate the effect of a berberine derivative, berberine8998, on serum cholesterol and lipid levels in-vivo and to explore the mechanisms involved.Methods - Lipid lowering effect of berberine and berberine
Autor:
Gangyi Liu, Yu-zhou Gui, Yun Liu, Chen Yu, Shuijun Li, Yan-mei Liu, Meng-qi Zhang, Jingying Jia, Chuan Lu
Publikováno v:
Biomedical Chromatography. 25:427-431
A liquid chromatography–tandem mass spectrometry (LC-MS/MS) method was developed to determine total N-acetylcysteine in human plasma. Mass spectrometric detection was achieved in positive electrospray ionization and multiple reaction monitoring mod