Výsledky vyhledávání - "Yu-suke Yamai"

First Total Synthesis of (–)-Merrillianin

Autor: Isamu Shiina, Takashi Iizumi, Saori Taniguchi, Masuhiro Sugimoto, Takahisa Shimazaki, Yu-suke Yamai, Go Ogawa, Tetsuro Yamada, Shojiro Shinohara, Yosuke Kageyama, Teppei Kuboki, Yuki Suwa, Keita Yonekura, Keiichi Ito, Kiyotaka Toyoyama, Satoru Tateyama, Takahiro Mori, Takatsugu Murata

The first total synthesis of (–)-merrillianin (1), which is a natural sesquiterpene with a tri- fused structure having a cyclopentane ring and five- and seven-membered lactone parts, is demonstrated. This asymmetric total synthesis enabled the abso

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a150bf020be51f15d63cc3b92fa74a8
https://doi.org/10.26434/chemrxiv-2022-0k1bz-v2

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Design, synthesis and evaluations of spiro‐fused benzoxaborin derivatives as novel boron‐containing compounds

Autor: Takaaki Sumiyoshi, Yasuo Nagaoka, Yu-suke Yamai, Itaru Natsutani, Riyo Iwata, Kyoji Ishida

Publikováno v: Chemical Biology & Drug Design. 93:657-665

Drug design using boron-containing heterocycles has attracted a great deal of attention because these compounds are believed to possess high biological activity. However, information on the synthetic methodology and pharmacokinetic profiling of boron

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https://doi.org/10.1111/cbdd.13496

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SYNTHESIS OF SUBSTITUTED t-BUTYL 3-ALKYLOXINDOLE-3-CARBOXYLATES FROM DI-t-BUTYL (2-NITROPHENYL)MALONATES

Autor: Shinichi Uesato, Kyoji Ishida, Tatsuo Yajima, Yasuo Nagaoka, Takaaki Sumiyoshi, Yu-suke Yamai, Itaru Natsutani, Akio Tanaka

Publikováno v: Heterocycles. 97(1):192-210

Using a novel tandem reduction-cyclization, we synthesized t-butyl 3-alkyloxindole-3-carboxylates from the di-t-butyl 2-alkyl-2-(2-nitrophenyl)malonate. Introduction of an α-substituent to the di-t-butyl 2-(2-nitrophenyl)-malonates and addition of a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04cbb7e546d74847b1d4831a2985354e
https://kansai-u.repo.nii.ac.jp/records/23353

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Discovery of new low-molecular-weight p53–Mdmx disruptors and their anti-cancer activities

Autor: Tsutomu Sasaki, Masato Enari, Shinichi Uesato, Takaaki Sumiyoshi, Suzuho Takemoto, Yu-suke Yamai, Yasuyuki Kawaratani, Kyoji Ishida, Yoshihiro Matsuura, Yoshiyuki Hirata, Saki Matsue

Publikováno v: Bioorganic & Medicinal Chemistry. 24:1919-1926

Although several p53-Mdm2-binding disruptors have been identified to date, few studies have been published on p53-Mdmx-interaction inhibitors. In the present study, we demonstrated that o-aminothiophenol derivatives with molecular weights of 200-300

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2dc4a26c62a73cd22f29074bbf826b63
https://doi.org/10.1016/j.bmc.2016.03.021

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Enantioselective Aldol Reaction of Tetrasubstituted Ketene Silyl Acetals with Achiral Aldehydes for the Construction of Asymmetric Tertiary Alcohols: An Application for the Divergent Total Syntheses of Buergerinins F and G

Autor: Yo Ko Yamada, Yu Suke Yamai, Yo Ichi Kawakita, Kazutoshi Yokoyama, Isamu Shiina, Takashi Iizumi

Publikováno v: Synthesis. 2009:2915-2926

The asymmetric aldol reaction of heteroatom-substituted ketene silyl acetals with achiral aldehydes has been developed by the promotion of tin(II) triflate coordinated with a chiral diamine to afford the corresponding aldols having chiral tertiary al

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https://doi.org/10.1055/s-0029-1216922

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Enantioselective Synthesis of the Optically Active α-Methylene-β-hydroxy Esters, Equivalent Compounds to Morita−Baylis−Hillman Adducts, Using Successive Asymmetric Aldol Reaction and Oxidative Deselenization

Autor: Isamu Shiina, Yu Suke Yamai, Takahisa Shimazaki

Publikováno v: The Journal of Organic Chemistry. 70:8103-8106

[Chemical reaction: See text] The asymmetric aldol reaction of a tetra-substituted ketene silyl acetal including an alkylseleno group with aldehydes has been developed by the promotion of Sn(OTf)2 coordinated with a chiral diamine to afford the corre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70a0a97cccb64ed80b20dc6248e8a42d
https://doi.org/10.1021/jo051276y

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Asymmetric total synthesis of octalactin B using a new and rapid lactonization

Autor: Isamu Shiina, Ryoutarou Ibuka, Minako Hashizume, Yu Suke Yamai, Hiromi Oshiumi

Publikováno v: Tetrahedron Letters. 45:543-547

A method for the synthesis of octalactin B is established via a new and quite effective mixed-anhydride lactonization for the synthesis of an eight-membered ring moiety using 2-methyl-6-nitrobenzoic anhydride with DMAP. Both an optically active linea

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https://doi.org/10.1016/j.tetlet.2003.10.213

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ChemInform Abstract: Enantioselective Aldol Reaction of Tetrasubstituted Ketene Silyl Acetals with Achiral Aldehydes for the Construction of Asymmetric Tertiary Alcohols: An Application for the Divergent Total Syntheses of Buergerinins F and G

Autor: Kazutoshi Yokoyama, Yo Ichi Kawakita, Takashi Iizumi, Isamu Shiina, Yu Suke Yamai, Yoko Yamada

Publikováno v: ChemInform. 41

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6f5930fce3f28e23bff0edd1c953b4a1
https://doi.org/10.1002/chin.201003050

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