Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Yu-lei Zhuang"'
Autor:
Yu-zhou Gui, Wei Wang, Qing-qing Wu, Qi-chen Ding, Hong-jie Qian, Qiu-bei Lu, Ying-jun Zhang, Yu-lei Zhuang, Li Deng, Ying-lin Zuo, Lin Luo, Jing-ying Jia
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Heart failure is the most costly cardiovascular disorder. New treatments are urgently needed. This study aims to evaluate the safety, pharmacokinetics, and pharmacodynamic profile of HEC95468, a soluble guanylate cyclase (sGC) stimulator, in healthy
Externí odkaz:
https://doaj.org/article/471eb2450690481191e91200a2f0c4db
Autor:
Yu-Xiang Ma, Fu-Rong Liu, Yang Zhang, Qun Chen, Zhi-Qiang Chen, Qian-Wen Liu, Yan Huang, Yun-Peng Yang, Wen-Feng Fang, Ning Xi, Ning Kang, Yu-Lei Zhuang, Qi Zhang, Ying-Zhi Jiang, Li Zhang, Hong-Yun Zhao
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
BackgroundCT053PTSA is a novel tyrosine kinase inhibitor that targets MET, AXL, VEGFR2, FLT3 and MERTK. Here, we present preclinical data about CT053PTSA, and we conducted the first-in-human (FIH) study to evaluate the use of CT053PTSA in adult patie
Externí odkaz:
https://doaj.org/article/9203def0acce4b9996448bf4531c81d0
Publikováno v:
Journal of Molecular Catalysis B: Enzymatic. 72:248-255
Microbial transformations of 14-deoxy-11, 12-didehyclroandrographolide (a) and 14-deoxyandrographolide (b) were performed by Cunninghamella blakesleana (AS 3.970), respectively. Sixteen metabolites were obtained and their structures were elucidated b
Publikováno v:
Journal of natural products. 72(9)
Three new triterpenoids, 11,21-dioxo-2beta,3beta,15alpha-trihydroxyurs-12-ene-2-O-beta-D-glucopyranoside (1), 11,21-dioxo-3beta,15alpha,24-trihydroxyurs-12-ene-24-O-beta-D-glucopyranoside (2), and 11,21-dioxo-3beta,15alpha,24-trihydroxyolean-12-ene-2
Publikováno v:
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 33(24)
To study the chemical constituents in Agrimonia pilosa.The compounds were isolated and purified by various column chromatographic methods and elucidated on the basis of chemical and spectroscopic evidences.Nine flavonoids were obtained and identified
Publikováno v:
Journal of Asian natural products research. 10(9-10)
Two new ent-labdane diterpenoid glycosides were isolated from the aerial parts of Andrographis paniculata. Their structures were elucidated as 3-O-beta-D-glucosyl-14-deoxyandrographiside (1) and 3-O-beta-D-glucosyl-14-deoxy-11,12-didehydroandrographi