Zobrazeno 1 - 10
of 94
pro vyhledávání: '"Yu-Wen Hwang"'
Autor:
Gian Luca Araldi, Yu-Wen Hwang
Publikováno v:
Pharmaceuticals, Vol 16, Iss 3, p 443 (2023)
Natural polyphenol derivatives such as those found in green tea have been known for a long time for their useful therapeutic activity. Starting from EGCG, we have discovered a new fluorinated polyphenol derivative (1c) characterized by improved inhib
Externí odkaz:
https://doaj.org/article/9fa7fd976f0746e6b93e47a79e47690b
Publikováno v:
F1000Research, Vol 6 (2017)
The DYRK1A (dual specificity tyrosine phosphorylation-regulated kinase 1A) gene encodes a proline-directed Ser/Thr kinase. Elevated expression and/or altered distribution of the kinase have been implicated in the neurological impairments associated w
Externí odkaz:
https://doaj.org/article/ad182e77fa314f819e2386e367fe48b4
Publikováno v:
F1000Research, Vol 6 (2017)
The DYRK1A (dual specificity tyrosine phosphorylation-regulated kinase 1A) gene encodes a proline-directed Ser/Thr kinase. Elevated expression and/or altered distribution of the kinase have been implicated in the neurological impairments associated w
Externí odkaz:
https://doaj.org/article/376cbc963abc493a8005b1505e8c458d
Autor:
Urszula Wojda, Tatyana Adayev, Tomasz Gabryelewicz, Anna Barczak, Katarzyna Brzozowska, Karol Dowjat, Yu-Wen Hwang
Publikováno v:
Journal of Alzheimer's Disease
Background DYRK1A is implicated in mental retardation and Alzheimer's disease (AD) dementia of Down syndrome (DS) individuals. The protein is associated with cytoskeleton and altered expression has been shown to impair the cytoskeletal network via do
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e72dac3dc43541c3b207a820b8cbbee0
https://doi.org/10.3233/jad-190475
https://doi.org/10.3233/jad-190475
Publikováno v:
PLoS ONE, Vol 7, Iss 4, p e34845 (2012)
Dyrk1A phosphorylated multiple proteins in the clathrin-coated vesicle (CCV) preparations obtained from rat brains. Mass spectrometric analysis identified MAP1A, MAP2, AP180, and α- and β-adaptins as the phosphorylated proteins in the CCVs. Each pr
Externí odkaz:
https://doaj.org/article/1fe7fe44eb524270bae30e326d99156b
Autor:
Yu-Wen Hwang, Elizabeth Kida, Ausma Rabe, Adam A. Golabek, Tatyana Adayev, Janusz Frackowiak, Michael Flory, Wojciech Kaczmarski, Bozena Mazur-Kolecka, Elaine Marchi, Jerzy Wegiel
Publikováno v:
Journal of Neuroscience Research. 90:999-1010
Overexpression of dual-specificity tyrosine-(Y)-phosphorylation-regulated kinase 1A (DYRK1A), encoded by a gene located in the Down syndrome (DS) critical region, is considered a major contributor to developmental abnormalities in DS. DYRK1A regulate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd889994d8567acb5f5c3039098f8022
https://doi.org/10.1002/jnr.23007
https://doi.org/10.1002/jnr.23007
Publikováno v:
Archives of Biochemistry and Biophysics. 507:212-218
Harmine is a β-carboline alkaloid. The compound is a potent inhibitor of dual-specificity tyrosine phosphorylation-regulated kinase 1A (Dyrk1A), a kinase implicated in Down syndrome. In this study, we show that harmine functions as an ATP-competitiv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14bff22fab4634be25d49641886abc5f
https://doi.org/10.1016/j.abb.2010.12.024
https://doi.org/10.1016/j.abb.2010.12.024
Autor:
Tatyana Adayev, Thomas Wisniewski, Wayne Silverman, Arthur J. Dalton, Khalid Iqbal, Kuo-Chiang Wang, Barry Reisberg, Fei Liu, Wojciech Kaczmarski, Shuang Yang Ma, Izabela Kuchna, Yu-Wen Hwang, Isabel Monteiro, Mony J. de Leon, Bozena Mazur-Kolecka, Jarek Wegiel, Inge-Grundke Iqbal, Cheng-Xin Gong, Janusz Frackowiak, Madhabi Barua, Krzysztof Nowicki, Florence Lai, Jerzy Wegiel
Publikováno v:
Journal of Neuropathology & Experimental Neurology. 70:36-50
Triplication of chromosome 21 in Down syndrome (DS) results in overexpression of the minibrain kinase/dual-specificity tyrosine phosphorylated and regulated kinase 1A gene (DYRK1A). DYRK1A phosphorylates cytoplasmic tau protein and appears in intrane
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::817d8f3282943bdec6d0c467bb117ec9
https://doi.org/10.1097/nen.0b013e318202bfa1
https://doi.org/10.1097/nen.0b013e318202bfa1
Publikováno v:
FEBS Journal. 278:236-245
Recent studies indicate that the dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A) gene, which is located on chromosome 21q22.2 and is overexpressed in Down syndrome (DS), may play a significant role in developmental brain defect
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::add3d24c66e6235c52e7e6ca9925d73c
https://doi.org/10.1111/j.1742-4658.2010.07955.x
https://doi.org/10.1111/j.1742-4658.2010.07955.x
Publikováno v:
Biochemistry. 48:9297-9305
In spite of a nuclear targeting sequence, a substantial amount of dual-specificity tyrosine phosphorylation-regulated kinase (Dyrk1A) is located within the cytoplasm of neurons. Analysis of fractionated rat brains revealed that the majority of Dyrk1A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca9ad21e2c8d9f2d7e8c113b1460f5f3
https://doi.org/10.1021/bi9010557
https://doi.org/10.1021/bi9010557