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Supplementary Figures S1-S12 from Natural Product Vibsanin A Induces Differentiation of Myeloid Leukemia Cells through PKC Activation

Differentiation induction activity of vibsanine A and its analogues on HL-60 Cells (S1); Characterization of differentiation-inducing activity of vibsanine A (S2); Vibsanine A-induced growth inhibition of myeloid leukemia cells (S3); Gene expression

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::304ab586364e63819856663ab3920a6b
https://doi.org/10.1158/0008-5472.22411308

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Data from Natural Product Vibsanin A Induces Differentiation of Myeloid Leukemia Cells through PKC Activation

All-trans retinoic acid (ATRA)-based cell differentiation therapy has been successful in treating acute promyelocytic leukemia, a unique subtype of acute myeloid leukemia (AML). However, other subtypes of AML display resistance to ATRA-based treatmen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a9c50441b1d3af23e6e042c660f626ec
https://doi.org/10.1158/0008-5472.c.6508191.v1

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Salt-inducible kinase inhibition sensitizes human acute myeloid leukemia cells to all-trans retinoic acid-induced differentiation

Autor: Wen-Yue Long, Zu-Yin Yu, Xue-wen Zhang, Guo-Lin Xiong, He Xiao, Xing Shen, Feng-Jun Li, Shuang Xing, Yu-Wen Cong

Publikováno v: International Journal of Hematology. 113:254-262

Differentiation therapies with all-trans retinoic acid (ATRA) have been successful in treating acute promyelocytic leukemia, a rare subtype of acute myeloid leukemia (AML). However, their efficacy is limited in the case of other AML subtypes. Here, w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb2ac81248347c4f9e374b7a68bc270b
https://doi.org/10.1007/s12185-020-03026-1

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Vibsanin A sensitizes human acute myeloid leukemia cells to tyrosine kinase inhibitor-induced myeloid differentiation via activation of PKC and upregulation of Lyn

Autor: Zuyin Yu, Qin-Shi Zhao, Hong-Ling Ou, Lu Zhang, Fang-Min Wang, Xing Shen, Yu-Wen Cong, He Xiao, Xin-Ru Wang, Guo-Lin Xiong, Shuang Xing, Ya-Jun Shan

Publikováno v: Biochemical and Biophysical Research Communications. 502:110-115

Differentiation therapies have been proposed to overcome the impaired cell differentiation in acute myeloid leukemia (AML). However, thus far the all-trans retinoic acid-based differentiation therapy has been the only successful modality in treating

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a385596cb26278741ea350440e6138c
https://doi.org/10.1016/j.bbrc.2018.05.129

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Natural Product Vibsanin A Induces Differentiation of Myeloid Leukemia Cells through PKC Activation

Publikováno v: Cancer Research. 76:2698-2709

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::356092539a5e3bbdc3b263eff9c4aece
https://doi.org/10.1158/0008-5472.can-15-1616

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Vibsanol A induces differentiation of acute myeloid leukemia cells via activation of the PKC signaling pathway and induction of ROS

Autor: Guo-Lin Xiong, Shuang Xing, He Xiao, Fang-Min Wang, Xin-Ru Wang, Hong-Ling Ou, Yu-Wen Cong, Meng Yang, Yan-Hong Tu, Lu Zhang, Xing Shen, Zuyin Yu

Publikováno v: Leukemialymphoma. 59(10)

Identifying novel differentiating agents to promote leukemia-cell differentiation is a pressing need. Here, we demonstrated that vibsanol A, a vibsane-type diterpenoid, inhibited the growth of acute myeloid leukemia (AML) cells via induction of cell

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e747253db9ee37394086df7f7189270
https://pubmed.ncbi.nlm.nih.gov/29334822

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Establishment of lineage tracing method of mice small intestinal stem cell and application in radiation injury

Autor: Tie-zhu XU, Yu CUI, Chao YANG, Li-mei WANG, Zhong-tang LI, Jun-ke WANG, Zhi-wei ZHAO, Ya-jun SHAN, Xiao-lan LIU, Yu-wen CONG

Publikováno v: Medical Journal of Chinese People's Liberation Army, Vol 40, Iss 5, Pp 349-353 (2015)

Objective To establish a lineage tracing method with Lgr5-EGFP-CreERT2/ROSA26-stop-EYFP mouse for observing the role of Lgr5+ intestinal stem cells in the renovation of small intestine tissue, and investigate the effects of radiation on the reconstru

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doajarticles::5bd9958fc2ebe5ec30d9e9ca41633521
http://www.plamj.org/index.php/plamj/article/view/1129

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